Significant alcohol intake produces changes in the brain's structure and chemistry, though some alterations occur with minimal use of alcohol over a short term period, such as tolerance and physical dependence.

Significant changes came in 1910 with the reform of the Roman Breviary by Pope Pius X.

Significant syntactic changes have arisen in Modern Hebrew as a result of non-Semitic substrate influences.

" Significant changes happened in the British Poor Law system in England and Wales, Scotland, and Ireland.

Significant changes occurred in the economy of the Tennessee Valley and the nation, prompted by an international oil embargo in 1973 and accelerating fuel costs later in the decade.

Significant crops in montane forest zones include tea and coffee, and the logging of unique species causes changes to the forest structure.

Significant changes in the number of fixed and mobile services deployed in Bangladesh occurred in the late 1990s and the number of services in operation have subsequently grown exponentially in the past five years.

Significant changes in its management and language were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes were made to the program as Ross asserted her influence.

Significant organisational changes to the base occurred as a result of the post-Cold War reorganization of the USAF.

Significant changes have occurred since the largest private shareholder, Alcatel, sold its stake in Thales to Dassault.

Significant changes are the improvement of the rear sight form transitioning from a V-notch type like those on a Type 38, to an aperture, the front sight blade was renewed to a triangular shape, chrome-lined barrels were used, and on earlier productions, the rear sight was equipped with anti-aircraft calipers.

Significant changes introduced into the 1968 document included Article 6, which committed the state to adhere to the " principles of socialist internationalism " and to devote special attention to its " fraternal ties " with the Soviet Union ; Article 9, which based the national economy on the " socialist ownership of the means of production "; Article 20, which under pressure from the churches granted freedom of conscience and belief ; Article 21, which maintained that the " basic rights " of citizenship were inseparably linked with " corresponding obligations "; and Article 47, which declared that the principle of " democratic centralism " is the authoritative maxim for the construction of the socialist state.

Significant changes in the language and management of the province were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes in pressure during the procedure can indicate tumors or spinal blockage resulting in a large pool of CSF, or hydrocephalus associated with large volumes of CSF.

Significant changes for the album Ageless Decay are the artwork by Dimitar Nikolov and the mixing and mastering by Tommy Hansen.

Significant changes were made to Dr. Loveless ( played by Kenneth Branagh in the film ).

Significant powertrain changes were made for 1986.

Significant hypercalcaemia can cause ECG changes mimicking an acute myocardial infarction.

Significant changes enacted at the national levels included the imposition of an income tax with the Sixteenth Amendment, direct election of Senators with the Seventeenth Amendment, Prohibition with the Eighteenth Amendment, and women's suffrage through the Nineteenth Amendment to the U. S. Constitution.

Significant changes under autonomy are the setting up of Distance Education Programmes ( DEP ) with IIT Bombay, with VJTI being a Remote Centre ; as also the modernization of the Library to a digital library.

Significant changes to the game's ending were made late in development following the September 11 attacks in New York, where the finale occurs.

Significant changes in cays and their surrounding ecosystems can result from natural phenomena such as severe El Niño Southern Oscillation ( ENSO ) cycles.

Significant changes in the Leaving Certificate maths curriculum were reflected in two new textbooks produced by the Irish Christian Brothers.

Significant differences from TCP were:

Significant amounts of energy and time were devoted to support and foster formal study of the balalaika, from which highly skilled ensemble groups such as the Osipov State Balalaika Orchestra emerged.

Significant wars were fought in Britain, where his general Agricola attempted to conquer Caledonia ( Scotland ), and in Dacia, where Domitian was unable to procure a decisive victory against king Decebalus.

" Significant amounts " of hexavalent chromium were found in the water of more than 40 homes in the area, some of which have now been fitted with state-monitored filters on their water supply.

Significant results were produced by Croatian mathematician Danilo Blanuša, who discovered two snarks in the 1940s, now known as Blanuša snarks ; prior to Blanuša's discovery, the only known snark was the Petersen graph ( Weisstein ).

Significant internal reforms were introduced during the later part of the 18th century, but the reform process was not allowed to run its course, as the Russian Empire, the Kingdom of Prussia and the Austrian Habsburg Monarchy through a series of invasions and partitions terminated the Commonwealth's independent existence in 1795.

Significant interpretations of his writings were produced by such sociological luminaries as Talcott Parsons and C. Wright Mills.

Significant contributions to oceanographic knowledge were made by the voyages of HMS Beagle in the 1830s, with Charles Darwin aboard ; HMS Challenger during the 1870s ; the USS Tuscarora ( 1873 – 76 ); and the German Gazelle ( 1874 – 76 ).

Significant amounts of the Soviet resources were allocated in aid to the other socialist states.

Significant events in the early development of rugby football were the production of the first set of written football laws at Rugby School in 1845, which was followed by the ' Cambridge Rules ' drawn up in 1848.

Significant amendments were made to the Constitution in 1991, and there have been a number of judicial interpretations made to take into account the fact that the Constitution covers a much smaller area than originally envisioned.

Significant were the contributions of Nicolas Jenson, Francesco Griffo, Aldus Manutius, and other printers of late fifteenth-century Europe.

Significant numbers of British Churchill and Matilda tanks along with US M3 Lee were shipped to the USSR after becoming obsolete on the African Front with the Churchills supplied by the arctic convoys seeing action around Leningrad while tanks shipped by the Persian route supplied the Caucasian Front.

Significant collections of Tiffany windows outside the United States are the 17 windows in the former Erskine and American United Church, now part of the Montreal Museum of Fine Arts in Montreal, Canada, and the two windows in the American Church in Paris, on the Quai d ' Orsay, which have been classified as National Monuments by the French government ; these were commissioned by Rodman Wanamaker in 1901 for the original American Church building on the right bank of the Seine.

Significant Huguenot settlements were in Dublin, Cork, Portarlington, Lisburn, Waterford and Youghal.

Significant early contributions to New Keynesian theory were compiled in 1991 by editors N. Gregory Mankiw and David Romer in New Keynesian Economics, volumes 1 and 2.

Significant events of the postwar era were the relocation of the university hospital from the city center to the Venusberg in 1949, the opening of the new university library in 1960 and the opening of a new building, the Juridicum, for the School of Law and Economics in 1967.

Significant evidence of this mining activity remains in the cave, including evidence of large amounts of saltpeter-bearing dirt that were removed, pick marks in the dirt, and an elaborate system of trails used by the miners.

* Significant portions of Fried Green Tomatoes were filmed in Newnan and Senoia.

Significant damage to an industrial plant with injuries, trapped people and destroyed homes were reported in Madison Parish near the Louisiana-Mississippi state line.

Significant gold mines in the nearby Santa Rosa Mountains were the National that produced in excess of 200, 000 ounces, and the Buckskin National that produced 24, 000 ounces of gold and 300, 000 ounces of silver over the period 1906 – 1941.

Significant portions of the 1961 film The Intruder ( Directed by Roger Corman and starring William Shatner ) were filmed in East Prairie.

Significant growth in the area, aided its proximity to Abilene, began to occur in the late 1980s and by 1992 there were 1, 441 people living in Potosi.