Significantly, long-term follow-up of these trials did not show a prolonged benefit of AZT, but also did not indicate that the drug increased disease progression or mortality.

Significantly, these mines were not very far from the lapis lazuli and spinel (" Balas Ruby ") mines in Badakhshan and, although separated by the formidable Pamir Mountains, routes across them were, apparently, in use from very early times.

Significantly, many of these sources targeted conservative markets, promoting traditional designs that appealed to small-town America.

Significantly, these proofs can be checked automatically, also by computer.

Significantly, modal logics can be developed to accommodate most of these idioms ; it is the fact of their common logical structure ( the use of " intensional " sentential operators ) that make them all varieties of the same thing.

Significantly, many of these filmmakers were the first students from the pioneering university film programs established in Los Angeles and New York.

Significantly, in the archives of Spain, there is no record of how Izquierdo, himself a liberal, could have been influenced to authorize these executions.

Significantly, these proofs can be checked automatically, also by computer.

Significantly, he does not object to these matters.

Significantly, the results of each of these sub patrols was to be reported in person to the 6th Bomber Command S-2 ( Intelligence ) by the Flight Commander as soon as it returned.

Significantly their live shows from this period included a good number of their eighties album tracks, however over time more of the " Core Seven " album era favourites would gradually begin to reappear in their playlist.

Significantly, Cortés was also granted an encomienda, which included all the Native Americans then living on the land and power of life and death over every soul on his domains.

Significantly more accurate predictions that included beta sheets were introduced in the 1970s and relied on statistical assessments based on probability parameters derived from known solved structures.

Significantly, although included in his map of 1436, the Antillia group is omitted in the later Andrea Bianco map of 1448, although some authors believe that two rectangular islands depicted by Bianco much further south ( in the environs of Cape Verde ), and labelled merely dos ermanos (" two brothers ") may be a reference to Antilia and Satanazes.

Significantly, in March and April 1903, when the Colonial Club of New York held its annual art show Exhibition of Paintings Mainly by New Men, among the twenty artists included were Robert Henri, John French Sloan, and Myers, showing their works together for the first time.

Significantly, the Paris codex included a frontispiece with a portrait of a man with a thin moustache in a black Burgundian chaperon that was instantly assumed to be the physical image of Prince Henry the Navigator ( there were no pictures of Henry before this ; the Paris frontispiece became the basis of modern images of the prince, reproduced in countless books, paintings and monuments since ).

Significantly, the new Coalition Government's legislative agenda announced in the Queen's Speech in May 2010, included two ideas originally put forward by Carswell.

Significantly, Anderson's position on the Middle East conflict was considerably more dovish than his stance towards the United States ' own wars, such as his aforementioned support for the military involvement in Vietnam.

Significantly, the duchy lacked its own diplomatic representation abroad.

Significantly, no other famine-struck country has published such criticisms of its own government ’ s actions.

Significantly re-invented the from the format of the Dionne Warwick original via the prominence of Clayton Ivey's piano work and the choral vocals of the Sweet Inspirations, the Aretha Franklin version was intended as the B-side of the July 1968 single release " The House that Jack Built " but began to accrue its own airplay that August.

Significantly, the only named characters are Lazarillo and his family: his mother Antoña Pérez, his father Tomé Gonzáles, and his stepfather El Zayde.

Significantly, if Eddie Irvine, who placed 7th at that race, had been able to pass Gené, he could have won that year's World Championship by a point.

Significantly, though, Thomas, Earl of Lancaster, who had not been involved in the campaign to exile Gaveston, seems to have become disaffected at this time.

Significantly broadening this picture are notable exceptions of SPD individuals who engage in occasional or even frequent sexual activities with others.

Significantly it was a military officer, R G Woodthorpe, who apparently initiated the idea of the conference almost four months earlier in his " Note on our Dealing with Savage Tribes and the Necessity for having them under One Rule ".

Significantly Ben Ali's last address to the nation prior to his flight abroad was given in Derja, the first time he had used this language in an official capacity ( unlike his predecessor, Habib Bourguiba, who frequently gave speeches in Derja ).

Significantly, in a contract of 1490 twenty-three master-potters of Montelupo agreed to sell the year's production to Francesco Antinori of Florence ; Montelupo provided the experienced potters who were set up in 1495 at the Villa Medicea di Cafaggiolo by its Medici owners.

Significantly, his stay at Sutter's Fort coincided with a visit by John C. Frémont, who had just explored the Great Salt Lake Desert and whose letter describing a new route to California would be widely published in Eastern newspapers.

Significantly, the Act also excludes employees who were dismissed for " genuine operational reasons or reasons including genuine operational reasons ".

Significantly, Huxley also worked for a time in the 1920s at the technologically advanced Brunner and Mond chemical plant in Billingham, Teesside, and the most recent introduction to his famous science fiction novel Brave New World ( 1932 ) states that this experience of " an ordered universe in a world of planless incoherence " was one source for the novel.

Significantly, the Quebec Act also replaced the French criminal law presumption of guilty until proven innocent with the English criminal law presumption of innocent until proven guilty ; but the French code or civil law system was retained for non-criminal matters.

Significantly, his first act as an Emperor was the deification of his brother Titus.

Significantly, it was stated that the definition does not have retrospective effect.

Significantly, in the history of education of the deaf, he said that deaf people were capable of using their minds, argued for the importance of teaching them, and was one of the first to state that deaf people could learn to read and write without learning how to speak first.

Significantly, Dafne was an attempt to revive the classical Greek drama, part of the wider revival of antiquity characteristic of the Renaissance.

Significantly, in the theatre of the ancient Latin-speaking world, the mask was not used as a plot device to disguise the identity of a character, but rather was a convention employed to represent or typify that character.

Significantly, though, the artists, writers, and patrons involved in the cultural movements in question believed they were living in a new era that was a clean break from the Middle Ages.

Significantly, the lack of any direct heirs from Richard was the first step in the dissolution of the Angevin Empire.

Significantly, at his coronation, he was anointed with holy oil that had reportedly been given to Becket by the Virgin Mary shortly before his death in 1170 ; this oil was placed inside a distinct eagle-shaped container of gold.

Significantly, the earliest surviving treatise to describe the modern movement of the queen ( as well as the bishop and pawn ), Repetición de amores e arte de axedres con CL iuegos de partido ( Discourses on Love and the Art of Chess with 150 Problems ) by Luis Ramírez de Lucena, was published during the reign of Isabella I of Castile.

Significantly, for Asterius the Christian feast was explicitly an entry from darkness into light, and although no conscious solar nature could have been expressed, it is certainly the renewed light at midwinter, which was celebrated among Roman pagans, officially from the time of Aurelian, as the " festival of the birth of the Unconquered Sun ".

Significantly, Australia's most successful bowler Clarrie Grimmett was replaced by Ward, one of four players making their debut.

Significantly, SN 2006jc was destroyed in a supernova explosion two years later, observed on October 9, 2006.

Significantly, the pairs of lacquers were labelled " Left " and " Right " respectively, rather than " A " and " B " as was usually the case.

Significantly, the reply a month later said the painting was not to be had at any price.

Significantly, there was a broad consensus of the basic framework among the officers.

Significantly, it was noted for Five Little Pigs ( adapted by Kevin Elyot ) bringing out the homosexual subtext of the novel.

Significantly, this contract was only with Kember and Pierce, meaning Spacemen 3 as a legal and financial entity would, in essence, constitute only the two of them together with Palmer.