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Since and RNA
Since the gels are fragile and the probes are unable to enter the matrix, the RNA samples, now separated by size, are transferred to a nylon membrane through a capillary or vacuum blotting system.
Since RNA is charged, metal ions such as Mg < sup > 2 +</ sup > are needed to stabilise many secondary and tertiary structures.
Although catalysis of the peptide bond involves the C2 hydroxyl of RNA's P-site ( see Function section below ) adenosine in a protein shuttle mechanism, other steps in protein synthesis ( such as translocation ) are caused by changes in protein conformations. Since their catalytic core is made of RNA, ribosomes are classified as " ribozymes ," and it is thought that they might be remnants of the RNA world.
Since thymine nucleotides are precursors of DNA, not RNA, the prefix " deoxy " is often left out, i. e., deoxythymidine is often just called thymidine.
After entering the hepatocyte, the virus is uncoated and the nucleocapsid translocated to the nucleus due to a signal in HDAg Since the nucleocapsid does not contain an RNA polymerase to replicate the virus ’ genome, the virus makes use of the cellular RNA polymerases Initially just RNA pol II, now RNA polymerases I and III have also been shown to be involved in HDV replication
Since Cech's and Altman's discovery, other investigators have discovered other examples of self-cleaving RNA or catalytic RNA molecules.
Since Blackburn has shown that most of the harmful cancer-related effects of telomerase are dependent on an intact RNA template, it seems a very worthwhile target for drug development.
Since photosynthesis and other natural processes create extremely complex molecules to the specifications contained in RNA and stored long-term in DNA form, advocates of molecular engineering claim that an artificial process can likewise exploit a chain of long-term storage, short-term storage, enzyme-like copying mechanisms similar to those in the cell, and ultimately produce complex molecules which need not be proteins.
Since RNA has a secondary structure that is not necessarily linear like that of DNA, the shape that goes along with the complementary bonding in the structure can have significant effects.
Since uracil is a normal component of RNA, the rationale behind the development of the drug was that cancer cells, with their increased genetic instability, might be more sensitive to ' decoy ' molecules that mimic the natural compound than normal cells.

Since and is
Since the Supreme Court's decision of that year this is more doubtful ; ;
( Since the time-span of the nation-state coincides roughly with the separate existence of the United States as an independent entity, it is perhaps natural for Americans to think of the nation as representative of the highest form of order, something permanent and unchanging.
Since it is not far from Viareggio, he will visit Puccini's house, as he never fails to do, to pay his respects to the memory of the composer of La Boheme, which he considers one of Puccini's masterpieces.
Since attack serves to stimulate interest in broadcasts, I added to my opening statement a sentence in which I claimed that German youth seemed to lack the enthusiasm which is a necessary ingredient of anger, and might be classified as uninterested and bored rather than angry.
Since the air is a continuum, the network of communication remains intact regardless of the positions or motions of the points ( the people ) in the net.
Since the hazards of poor communication are so great, p can be justified as a habitable site only on the basis of unusual productivity such as is made available by a waterfall for milling purposes, a mine, or a sugar maple camp.
Since the difficulty of drawing the net is great, we will merely discuss it.
Since a civilizational crisis involves also a crisis in private interests and in the ruling class, reaction is normally found among those who feel themselves to be among the ruling class.
Since civilizational change is the most difficult to perceive and analyze, it seldom is given adequate attention.
Since the slogans have little application to reality and are sanctimonious to boot, the applause is faint even in areas of the world where we should expect to find the greatest affection for free government.
Since more is known about Quiney than about any other acquaintance of Shakespeare in Stratford, his career may be followed to its sudden end in 1602.
Since the great flood of these dystopias has appeared only in the last twelve years, it seems fairly reasonable to assume that the chief impetus was the 1949 publication of Nineteen Eighty-Four, an assumption which is supported by the frequent echoes of such details as Room 101, along with education by conditioning from Brave New World, a book to which science-fiction writers may well have returned with new interest after reading the more powerful Orwell dystopia.
Since Laos is of no more purely military value to Moscow itself than it is to Washington, this approach might be expected to head off Mr. Khrushchev for the moment.
Since little is known about autism, and almost nothing has been written for the layman, we'd like to share one experienced mother's comments.
Since the work is done by hand, the only limitation, it is said, `` is that of human conception ''.
Since the apparatus is new, it requires experimentation and changes in technique.
Since the obvious is not always true, the Republican National Committee wisely analyzed its defeat of last autumn and finds that it occurred, as suspected, in the larger cities.
Since he has just shown who is top dog, he may not be ready to receive this highest honor in the gift of the Soviet people.
Since appeals to morality, to humanity, and to sanity have had such small effect, perhaps our last recourse is the deterrent example.
Since the goal of our international planners is a World Government, this Atlantic Community would mark a giant step in that direction for, once American economic autonomy is absorbed, a larger grouping is a question of time.

Since and first
Since she could not act, one part suited her as well as any other, and so she was the first person to offer Mr. Lincoln a glass of water, holding it up to the box, high above her head, to Miss Harris, who had asked for it.
Since ordinary breakfast-table conversation was impossible, it was at least something that they were able to offer Eugene the sugar bowl with their sugar in it, and the plate of bread and butter, and that Eugene could return the pitcher of hot milk to them handle first.
Since accurate base maps are necessary for any planning program, the first step taken by the planning division to implement the long-range state plan has been to prepare two series of base maps -- one at a scale of 1 inch to a mile, and the second a series of 26 sheets at a scale of 1 inch to 2000 feet, covering the entire state.
Since the mid 1950s, when urethane foam first made its appearance in the American market, growth has been little short of fantastic.
Since a fall or blow might have caused it, a cold pack was usually first aid.
Since then and during the first decade, the results were given to newspapers for publication at 11 pm on the night of the awards.
Since some of the Roman months were named in honor of divinities, and as April was sacred to the goddess Venus, the Festum Veneris et Fortunae Virilis being held on the first day, it has been suggested that Aprilis was originally her month Aphrilis, from her equivalent Greek goddess name Aphrodite ( Aphros ), or from the Etruscan name Apru.
Since the fluctuations are assumed to be small, products of the fluctuation terms can be neglected ( to first order ) and we have
Since this picture was first developed by Ernst Stueckelberg, and acquired its modern form in Feynman's work, it is called the Feynman-Stueckelberg interpretation of antiparticles to honor both scientists.
Since the first discovery in 1884, fossils of more than thirty individuals have been recovered, providing scientists with a more detailed knowledge of Albertosaurus anatomy than is available for most other tyrannosaurids.
Since the first pioneering efforts of Florey and Chain in 1939, the importance of antibiotics, including antibacterials, to medicine has led to intense research into producing antibacterials at large scales.
Since the start of the 2008 season, the Falcons have recorded four consecutive winning seasons for the first time in franchise history.
School ( 1904 ) Sanskriti ... The School ( 2004 ) and Sophia Girls ' School ( 1918 / 1935 ) & College ( 1942 ), Rashtriya Military School Ajmer ( Since 2010-Established in 1930 as King George ’ s Royal Indian Military School ), and the historic Ajmer Music College, founded in 1942, the first accredited institution in Rajputana for teaching Hindustani classical music.
Since electricity is an expensive utility, the first step towards conservation is to design a house and lifestyle to reduce demand.
Since the bigger 1 / 4 " tapioca pearls are separately sold as " black pearls " ( 黑珍珠 ) in markets, this name was the logical first choice and is more popular with the consumers of the drink.
* Since Big Brother 2, the UK series always opens with a twist which have included the public being able to choose the final housemate out of three possibilities ( Big Brother 2 ), the public voting for a housemate to leave during the first week and then the housemates choosing between the two housemates with the least number of votes ( Big Brother 3 ), First Night Nominations ( Big Brother 4 ), Suitcase Nominations ( Big Brother 5 ), Unlucky Housemate 13 ( Big Brother 6 ), Big Brother Hood ( Big Brother 7 ), an all-female House and the first inclusion of twins as contestants ( Big Brother 8 ), the first couple to enter as housemates and set a secret task to hide their real relationship ( Big Brother 9 ), all " housemates " really being " non-housemates " who had to earn their housemate status ( Big Brother 10 ), a mole entering the House with an " Impossible Task " ( Big Brother 11 ), Jackie Stallone entering a house containing her son's ex-wife ( Celebrity Big Brother 3 ), the entrance of a non-celebrity in a celebrity edition ( Celebrity Big Brother 4 ) and Jade Goody's family announced to be visiting.
Since the introduction of the first commercially available microprocessor ( the Intel 4004 ) in 1970, and the first widely used microprocessor ( the Intel 8080 ) in 1974, this class of CPUs has almost completely overtaken all other central processing unit implementation methods.
Since 1979, a facsimile edition of that first edition has been available in four paper-bound volumes.
Since its obtainment was considerably more expensive than that of brick, sandstone only gradually came into use, and at first was used for particular elements such as door frames.
Since the consolidation of newspaper comics by the first quarter of the 20th century, most cartoonists have used a group of assistants ( with usually one of them credited ).
The proof of this fact relies on an algorithm which, given the first n digits of Ω, solves Turing's halting problem for programs of length up to n. Since the halting problem is undecidable, Ω can not be computed.
Since the mechanism of retention on this new solid support is different from the first dimensional separation, it can be possible to separate compounds that are indistinguishable by one-dimensional chromatography.

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