Specific mutations in p53 can disrupt these functions, allowing an abnormal cell to continue growing unchecked, resulting in the development of tumors.

Specific dates would be important, as would double names.

Specific religious social teachings ( for example, the direction of prayer, or dietary restrictions ) may be revoked by a subsequent manifestation so that a more appropriate requirement for the time and place may be established.

Specific acquired immunity against infectious diseases may be mediated by antibodies and / or T lymphocytes.

Specific objects or even days can be holy, but they derive holiness from being connected with God — the seventh day, the tabernacle, and the priests all derive their holiness from God.

Specific attention should be paid to blood pressure during the procedure and the level of the anesthetic should be regularly and appropriately topped up since non-epinephrine anestetics take longer to come into effect and wear off faster.

Specific amino acid sequences ( PTS or peroxisomal targeting signal ) at the C-terminus ( PTS1 ) or N-terminus ( PTS2 ) of peroxisomal matrix proteins signals them to be imported into the organelle.

Specific studies have found pedestrian walking speeds ranging from 4. 51 km / h to 4. 75 km / h for older individuals to 5. 32 km / h to 5. 43 km / h for younger individuals, although a brisk walking speed can be around 6. 5 km / h and champion racewalkers can average more than 14 km / h over a distance of 20 km.

Specific regulatory frameworks and questions related to Paramedic practice can only definitively be answered by consulting relevant provincial legislation, although provincial Paramedic Associations may often offer a simpler overview of this topic when it is restricted to a province-by-province basis.

Specific immunomodulatory therapies, such as the TNFα antagonists ( e. g. etanercept ), the B cell depleting agent rituximab, the anti-IL-6 receptor tocilizumab and the costimulation blocker abatacept have been shown to be useful in treating RA.

Specific historical facts about Donaldsonville can be learned through the books of Sidney Marchand ( historian, mayor, legislator, attorney ).

Specific legislation may require that all government meetings be open to the public, or that written records be released upon request.

MOF can be viewed as a standard to write metamodels, for example in order to model the abstract syntax of Domain Specific Languages.

Specific military operations can also be characterized as following the adhocracy model in form and function.

They can be formulated as SMART criteria: Specific, Measurable ( or at least evaluable ) achievement, Achievable ( recently Agreed-to or Acceptable are used regularly as well ), realistic ( given the current state of organizational resources ) and Time terminated ( bounded ).

Specific referral can be made to the International Civil Service Commission ( ICSC ) of the United Nations, an independent expert body established by the United Nations General Assembly.

Specific considerations for business intelligence systems have to be taken in some sectors such as governmental banking regulations.

The Jealousy Specific Innate Model ( JSIM ) proved to not be innate, but may be sensitive to situational factors.

Specific fuel consumption of air-breathing jet engines at their maximum efficiency vary more or less inversely with speed, which in turn means that the fuel consumption per mile or km can be a more appropriate comparison metric for aircraft that travel at very different speeds.

* Specific tests on reproductive function, embryonic toxicity, or carcinogenic potential can all be required by law, depending on the result of other studies and the type of drug being tested.

As noted the specific impulse of monopropellants is lower than bipropellants and can be found with the Air Force Chemical Equilibrium Specific Impulse Code tool.

Specific exceptions are made for cases in which the addition of a period or comma could create confusion, such as the quotation of web addresses or certain types of data strings.

Specific episodes are made easier to remember and recall by repeatedly exposing oneself to them ( which strengthens the links in the memory space ) allowing for faster retrieval when remembering.

Specific enhancements were made to add channel hopping and a variable time slot option compatible with ISA100. 11a.

Specific diagnosis of infection with is made by finding the virus in the child's stool by enzyme immunoassay.

Specific penalties are applied, consideration of profit gained from offence is considered and often added to fines, application for a formal restoration order is made making the offender responsible for restoration of SSSI ( at offender's expense ).

Specific diagnosis of norovirus is routinely made by polymerase chain reaction ( PCR ) assays or real-time PCR assays, which give results within a few hours.

Specific references to Tim Stoen, the father of John Stoen, including the logistics of possibly murdering him, are made on the Temple's final " death tape ," as well as a discussion over whether the Temple should include John Stoen among those committing " revolutionary suicide.

Specific designs involve the rotor of the pump being made of a steel, coated with a smooth hard surface, normally chromium, with the body ( the stator ) made of a molded elastomer inside a metal tube body.

Specific modifications on fibre proteins are used to target Adenovirus to certain cell types ; a major effort is made to limit hepatotoxicity and prevent multiple organ failure.

Specific claims of such funding have been made against conservative Republican supporter and billionaire Richard Mellon Scaife.

Specific roles are sometimes made for the corps de ballet, such as the Snow Corps de Ballet and the Flower corps in Nutcracker.

Specific reference may be made to new arrivals and historic records in order to impart understanding of the changes in an area's vegetation over time.

Specific plans for names, nicknames, and colors were developed by a committee of nine persons that made final reports to the School Board in December 1978.

Specific changes to the host organism may be made to improve expression of the ectopic gene.

Specific legislation may be made, e. g. for beachcombing.

General Specific used to be one of his clients until he said the center made him madder, making the Angry Scientist expel him, claiming it was an ' Anger Management Center ' and not a ' Madness Management Center '.

Specific issues of banknotes have been made for the Falkland Islands since 1899.

Specific Studies were also made of two plants at Zion and Indian Point — the so called Z / IP Study.

Specific testers were made that simply compared the electrical signals and stimuli on the test socket with the design values.

Specific situations include those where additional demands are made on the circulation, such as in pregnancy.