The U. S. National Center for Complementary and Alternative Medicine has issued an advisory indicating the marketing claims made about colloidal silver are scientifically unsupported, the silver content of marketed supplements varies widely, and colloidal silver products can have serious side effects to the consumer, including " argyria ,... neurologic problems ( such as seizures ), kidney damage, stomach distress, headaches, fatigue, and skin irritation.

The U. S. National Center for Complementary and Alternative Medicine found that " there is currently little evidence that bitter orange is safer to use than ephedra.

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