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The US National Center for Complementary and Alternative Medicine ( NCCAM ) classifies CAM therapies into five categories or domains, including: alternative medical systems, or complete systems of therapy and practice ; mind-body interventions, or techniques designed to facilitate the mind's effect on bodily functions and symptoms ; biologically based systems including herbalism ; and manipulative and body-based methods such as chiropractic and massage therapy.

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The US National Center for Complementary and Alternative Medicine ( NCCAM ) reported that oral administration of grape seed extract was well tolerated in people over 8 weeks of a clinical trial.

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