Despite the sheer beauty and spectacle of numerous documentaries, art films, and travelogues, despite the impressive financial success of such a recent development as Cinerama, the movies are at heart a form of fiction, like the play, the novel, or the short story.

Corruption is hardly a recent development in the city and state that were widely identified as the locale of Edwin O'Connor's novel, `` The Last Hurrah ''.

* Metabotropic glutamate receptor 2 agonism has been seen as a promising strategy in the development of novel antipsychotics.

Another type of data that requires novel informatics development is the analysis of lesions found to be recurrent among many tumors

An Entwicklungsroman (" development novel ") is a story of general growth rather than self-cultivation.

An Erziehungsroman (" education novel ") focuses on training and formal schooling, while a Künstlerroman (" artist novel ") is about the development of an artist and shows a growth of the self.

The novel has been variously read as an allegory for the development of civilisation, as a manifesto of economic individualism and as an expression of European colonial desires but it also shows the importance of repentance and illustrates the strength of Defoe's religious convictions.

Immersive virtual musical instruments, or immersive virtual instruments for music and sound aim to represent musical events and sound parameters in a virtual reality so that they can be perceived not only through auditory feedback but also visually in 3D and possibly through tactile as well as haptic feedback, allowing the development of novel interaction metaphors beyond manipulation such as prehension.

In the 12th century CE the Andalusian Muslim philosopher and novelist Abu Bakr Ibn Tufail ( known as " Abubacer " or " Ebn Tophail " in the West ) included the theory of tabula rasa as a thought experiment in his Arabic philosophical novel, Hayy ibn Yaqdhan in which he depicted the development of the mind of a feral child " from a tabula rasa to that of an adult, in complete isolation from society " on a desert island, through experience alone.

Lewis's tale appalled some contemporary readers ; however his portrayal of depraved monks, sadistic inquisitors and spectral nuns, and his scurrilous view of the Catholic Church was an important development in the genre and influenced established terror-writer Anne Radcliffe in her last novel The Italian ( 1797 ).

The Revolution of 1946 was a novel development in Haiti's history, as the Garde assumed power as an institution, not as the instrument of a particular commander.

His sentimental novel Julie, or the New Heloise was of importance to the development of pre-romanticism and romanticism in fiction.

Their research focus is Mars Analogue Research, e. g. the AustroMars mission with roughly 130 volunteers supporting a mission simulation at the Mars Desert Research Station ( MDRS ) and the ongoing PolAres multi-year research program which encompass the development of a Mars analogue rover system ans a novel spacesuit prototype dubbed " Aouda. X ", culminating in an arctic expedition in 2011.

However, in recent years our increased understanding of the basic mechanisms of NMT and autoimmunity has led to the development of novel treatment strategies.

The development of a number of novel probes for noninvasive, in vivo PET imaging of neuroaggregate in human brain has brought amyloid imaging to the doorstep of clinical use.

This becomes especially true as software development is often the realization of a new or novel product.

Following the 18th-century development of the novel as a literary form, in the early 19th century, Mary Shelley's books Frankenstein and The Last Man helped define the form of the science fiction novel ; later Edgar Allan Poe wrote a story about a flight to the moon.

The mid 17th century in France saw the development of a refined short novel, the " nouvelle ", by such authors as Madame de Lafayette.

Gilliam has several projects in various states of development, including an adaptation of Neil Gaiman's and Terry Pratchett's comic fantasy novel Good Omens.

Because interspersed repeats block gene conversion, they protect novel gene sequences from being overwritten by similar gene sequences and thereby facilitate the development of new genes.

In the 12th century, the Andalusian-Islamic philosopher and novelist Ibn Tufail ( known as " Abubacer " or " Ebn Tophail " in the West ) demonstrated the theory of tabula rasa as a thought experiment through his Arabic philosophical novel, Hayy ibn Yaqzan, in which he depicted the development of the mind of a feral child " from a tabula rasa to that of an adult, in complete isolation from society " on a desert island, through experience alone.

Immersive virtual musical instruments build on the trend in electronic musical instruments to develop new ways to control sound and perform music such as evidenced by conferences like NIME and aim to represent musical events and sound parameters in a virtual reality in such a way that they can be perceived not only through auditory feedback, but also visually in 3D and possibly through tactile as well as haptic feedback, allowing the development of novel interaction metaphors beyond manipulation such as prehension.

Water Margin is often seen as the first full-length wuxia novel: the portrayal of the 108 heroes, and their code of honour and willingness to become outlaws rather than serve a corrupt government, played an influential role in the development of jianghu culture in later centuries.

The discovery and development of this sulfonamide drug opened the era of antibacterial antibiotics.

For their discovery and development of penicillin as a therapeutic drug, Ernst Chain, Howard Florey, and Alexander Fleming shared the 1945 Nobel Prize in Medicine.

Fleming was modest about his part in the development of penicillin, describing his fame as the " Fleming Myth " and he praised Florey and Chain for transforming the laboratory curiosity into a practical drug.

This fact makes therapeutic target development extremely difficult – a drug that harms an apicomplexan parasite is also likely to harm its human host.

Efficacy of antipsychotics may likewise be reduced over time, due to this development of drug tolerance.

It generates new knowledge that is useful in such fields as drug design and development of new software tools to create that knowledge.

With modern biotechnology, these genes can be used as targets for the development of effective new therapies, which could significantly shorten the drug discovery process.

Since then, many other drugs have been developed to treat cancer, and drug development has exploded into a multibillion-dollar industry, although the principles and limitations of chemotherapy discovered by the early researchers still apply.

This method, widely used in drug development, is referred to as rNPV ( risk-adjusted NPV ), and similar methods are used to incorporate credit risk in the probability model of CDS valuation.

This rise of underground cinema coincided with Germany's surge drug culture and related rave clubs leading to the development of many subculture movies like September a movie in the vain of Dope ( London 1968 ).

The effect that Brindley discovered established the fundamentals for the later development of specific, safe, orally effective drug therapies.

Stories earlier in the timeline feature technology such as Bussard ramjets, Drouds ( wires capable of directly stimulating the pleasure centers of the brain ) and explore how organ transplantation technology enables the new crime of organlegging ( as well as the general sociological effects of widespread transplant technology ), while later stories feature hyperdrive, invulnerable starship hulls, stasis fields, molecular monofilaments, transfer booths ( teleporters used only on planetary surfaces ), the lifespan-extending drug boosterspice, and the tasp which is an extension of the wirehead development which works without direct contact.

Research: methodology and design of psychopharmacology research, interpretation and evaluation, FDA drug development and other regulatory processes.

Further improvement occurred with the development of compounds ( moclobemide and toloxatone ) that not only are selective but cause reversible MAO-A inhibition and a reduction in dietary and drug interactions.

Hepatotoxicity and drug-induced liver injury account for a substantial number of failures of new drugs in development and market withdrawal, highlighting the need for screening assays such as stem cell-derived hepatocyte-like cells, that are capable of detecting toxicity early in the drug development process.

Environmental factors associated with the development of schizophrenia include the living environment, drug use and prenatal stressors.

The drug was discovered to be teratogenic, causing serious genetic damage to early embryonic growth and development, leading to limb deformation in babies.

* February 15 – The discovery and clinical development of Prontosil, the first broadly effective antibacterial drug, is published in a series of articles in Germany's pre-eminent medical journal, Deutsche Medizinische Wochenschrift, by Gerhard Domagk.

In the pharmaceutical industry, the patent protection of drugs and medicines is accorded a particular importance, because drugs and medicines can easily be copied or imitated ( by analyzing a pharmaceutical substance ) and because of the significant research and development spending and the high risks associated with the development of a new drug.

Kesey's experiences while under the influence of LSD inspired him to promote the drug outside the context of the MKUltra experiments, which influenced the early development of hippie culture.

In this context the elucidation of the molecular mechanisms responsible for the switch from planktonic growth to a biofilm phenotype and the role of inter-bacterial communication in persistent disease should provide new insights in P. aeruginosa pathogenicity, contribute to a better clinical management of chronically infected patients and should lead to the identification of new drug targets for the development of alternative anti-infective treatment strategies.

Veterinary pathologists are critical participants in the drug development process.

FDA label information for Vidaza, a formulation of 5-azacitidine ( an unmethylatable analog of cytidine that causes hypomethylation when incorporated into DNA ) states that " men should be advised not to father a child " while using the drug, citing evidence in treated male mice of reduced fertility, increased embryo loss, and abnormal embryo development .< ref >