Even when this elder brother first displayed symptoms of delicate health, the notion that he might die young was never taken seriously, and he was betrothed to the Princess Maria Feodorovna ( Dagmar of Denmark ).

A speech given on 3 November 1906 was the first time the pathology and the clinical symptoms of presenile dementia were presented together.

The proposed mechanism of chronic nicotine causing desensitisation of nicotinic receptors, thereby leading to an antidepressant effect, is consistent with the theory first proposed over 30 years ago and subsequent research that confirmed excessive acetylcholine activity in the brain leads to depressive symptoms.

They are used to treat a wide variety of conditions and symptoms and are usually a first choice when short-term CNS sedation is needed.

Christopher Hitchens was offended by the notion of Clinton as the first black president noting " we can still define blackness by the following symptoms: alcoholic mothers, under-the-bridge habits ... the tendency to sexual predation and shameless perjury about the same ".

People who die from this form of plague often die on the same day symptoms first appear.

Protracted symptoms tend to resemble those seen during the first couple of months of withdrawal but usually are of a sub acute level of severity.

He at first believed he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms ( swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers ).

This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of " noxious agents " as he at first called it.

More recently, the use of a " rescue instillation " composed of pentosan polysulfate or heparin, sodium hyaluronate, lidocaine and sodium bicarbonate, has generated considerable excitement in the IC / BPS community because it is the first therapeutic intervention that can be used to reduce a flare of symptoms.

Patients develop the first symptoms mainly during adolescence.

The symptoms will start in the first two days and disappear within a few weeks after birth.

The symptoms of CMS usually begin within the first two years of life, although in a few forms, patients can develop their first symptoms as late as the seventh decade of life.

A further factor that leads to misdiagnosis of quinolone adverse effects is some symptoms can persist or occur for the first time quite some time after a course of quinolone has been finished, so inquiring about distant-past use of quinolones has been recommended.

There are significant differences in treatment between the two, for instance in the use of anti-inflammatory medicines, but they often present similar symptoms at first glance and so can easily be confused.

The first joint symptoms that patients with scleroderma have are typically non specific joint pains, which can lead to arthritis, or cause discomfort in tendons or muscles.

What can make PTS difficult to diagnose is the fact that symptoms can often first appear long after the actual cause of the syrinx occurred, e. g. a car accident occurring and then the patient first experiencing PTS symptoms such as pain, loss of sensation, reduced ability on the skin to feel varying degrees of hot and cold, a number of months after car accident.

On first viewing The Texas Chain Saw Massacre they experienced symptoms of depression and anxiety ; however, upon subsequent viewing they found the violence against women less offensive and more enjoyable.

Being somewhat delicate in health, at the age of sixteen he was sent to Southern Europe, for which he at once developed a passion, so that he spent nearly all of the following ten years abroad, at first in Italy, then in Greece, Egypt, Asia Minor, and Palestine.

Before being daughter, wife, or mother, before being cultured ( a word now bereft both socially and politically of the sheen you children of frontiersmen bestowed on it ), before being sorry for the poor, progressive about public health, and prettily if somewhat imprecisely humanitarian, indeed first and foremost, you were a lady.

In later years Josephus Daniels was to claim that World War 1, was the first in American history in which there was great concern for both the health and morals of our soldiers.

The Senate Subcommittee on Reorganization and International Organizations was provided samples of visual aids on first aid and personal health produced by the Medical Illustration Service.

When you first acquire a pool, we earnestly recommend -- for your own mental health -- a good long chat with your insurance agent.

Living in worsening poverty, neglecting his health, and drinking excessively, Jarry went on to write what is often cited as the first cyborg sex novel, Le Surmâle ( The Supermale ), which is partly a satire on the Symbolist ideal of self-transcendence.

After a failed health care reform attempt, Republicans won control of Congress in 1994, for the first time in forty years.

Though at first well received in political circles, it was eventually doomed by well-organized opposition from conservatives, the American Medical Association, and the health insurance industry.

Health care providers and public health officers are among the first lines of defense.

On July 1, 2003, Christopher Swain of Portland, Oregon, became the first person to swim the Columbia River's entire length, in an effort to raise public awareness about the river's environmental health.

By then Wilson was the last surviving member of Attlee's cabinet and the unveiling of the statue would be the last public appearance by Wilson, who was by then in the first stages of Alzheimer's Disease and who died in May 1995 after a decade of ill health.

Although the first, which emphasizes the potential for energy and resource conservation and health benefits gained from cycling versus automobile use, is relatively undisputed, the second is the subject of much debate.

While raising Chicago, and at first improving the health of the city, the untreated sewage and industrial waste now flowed into the Chicago River, then into Lake Michigan, polluting the primary source of fresh water for the city.

The disease was named after the Brazilian physician and infectologist Carlos Chagas, who first described it in 1909, but the disease was not seen as a major public health problem in humans until the 1960s ( the outbreak of Chagas disease in Brazil in the 1920s went widely ignored ).

An option for treating partners of patients ( index cases ) diagnosed with chlamydia or gonorrhea is patient-delivered partner therapy ( PDT or PDPT ), which is the clinical practice of treating the sex partners of index cases by providing prescriptions or medications to the patient to take to his / her partner without the health care provider first examining the partner.

Andropov's health declined rapidly during the tense summer and fall of 1983, and he became the first Soviet leader to miss the anniversary celebrations of the 1917 revolution that November.

Cholera became the first reportable disease in the United States due to the significant effects it had on health.

Dr. John M. Harris started the world's first dental school in Bainbridge, Ohio, and helped to establish dentistry as a health profession.

He was probably the first president to release information about his health and medical records while in office, On September 24, 1955, while vacationing in Colorado, he had a serious heart attack that required six weeks ' hospitalization, during which time Nixon, Dulles and Sherman Adams assumed administrative duties and provided communication with the President.

The term started to get its modern negative meaning with Cornelius Sulla's ascension to the dictatorship following Sulla's second civil war, making himself the first Dictator in more than a century ( during which the office was ostensibly abolished ) as well as de facto eliminating the time limit and need of senatorial acclamation, although he avoided a major constitutional crisis by resigning the office after about one year due to poor health, dying shortly after.

After an initial six-month review process, William Ruckelshaus, the Agency's first Administrator rejected an immediate suspension of DDT's registration, citing studies from the EPA's internal staff stating that DDT was not an imminent danger to human health and wildlife.

There is a wide array of power-ups, such as a backpack that increases the player character's ammunition-carrying capacity, armor, first aid kits to restore health, the berserk pack ( a dark first aid box that puts the character into berserk mode, allowing him to deal out rocket launcher-level damage with his fists and potentially splattering former humans and imps, as well as setting the user's health to 100 % if it were lower ), supernatural blue orbs ( named soul spheres in the manuals ) that boost the player character's health up to a maximum of 200 %, nightvision, computer maps ( which show every area of the level ), partial invisibility, and protective suits that allow the player to survive in toxic acids.

Although we are still far from a complete understanding of these problems, as a first approximation, it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic-cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances, in experimental and clinical neurosis, and as the result of psychopharmacological agents.

It seems to me, the first thing you've got to do, to be happy, is to face up to your problems, no matter what they may be.

One of the vexatious problems to first confront President Kennedy was the property lying just across Pennsylvania Avenue from the White House.

A young real estate salesman, Kern first got seriously interested in the problems posed by Communism when in the Navy Air Force.

Herodotus first formulated some of the persistent problems of anthropology.

Maj. Gen. Polk ignored the problems of Fort Henry and Fort Donelson when he took command and, after Johnston took command, at first refused to comply with Johnston's order to send an engineer, Lt. Joseph K. Dixon, to inspect the forts.

A broad public discussion of environmental problems began in the mid-1980s, when the first " green " groups formed in opposition to Yerevan's intense industrial air pollution and to nuclear power generation in the wake of the 1986 reactor explosion at Chernobyl '.

After what the MCC saw as the problems of the earlier professional and amateur series they decided to take control of organising tours themselves, and this led to the first MCC tour of Australia in 1903 – 04.

George W. Snedecor, the head of Iowa State's Statistics Department, was very likely the first user of an electronic digital computer to solve real world mathematics problems.

Cruder forms of accounting were inadequate for the problems created by a business entity involving multiple investors, so double-entry bookkeeping first emerged in northern Italy in the 14th century, where trading ventures began to require more capital than a single individual was able to invest.

When problems with poor control at high speed were first encountered, they were addressed by designing a new style of control surface with more power.

Colonel Kari Renko, an engineer at the Finnish Air Force, was quoted by Helsingin Sanomat as saying about this failure, " The problem involves the rocket engines which have been in use for decades " and that Finland first was told of the problems by the Americans about two years ago.

For the remainder of his reign there are problems: one of his sons rapes one of his daughters, another son kills the first, his favourite son rebels and is killed, until finally only two contenders for the succession remain, one of them Bathsheba's son Solomon.

Establishing the truth or falsehood of the continuum hypothesis is the first of Hilbert's 23 problems presented in the year 1900.

But as the halting problem is not generally solvable, and therefore calculating any but the first few bits of Chaitin's constant is not possible, this just reduces hard problems to impossible ones, much like trying to build an oracle machine for the halting problem would be.

The Bluebirds suffered from financial problems in their first two seasons.

This controller chip, however, was the seat of some early problems with 1581 drives when the first production runs were recalled due to a high failure rate ; the problem was quickly corrected.

The first generation of 6x86 had heat problems.

But due to some internal problems, the census was delayed till start of 2011 and its first phase was started in April allover the country.

In 1968, just before he published the first volume, Knuth accepted a job working on problems for the National Security Agency ( NSA ) through their FFRDC the Institute for Defense Analyses ( IDA ) Communications Research Division situated at the time on the Princeton campus in the Von Neumann building as stated in his cumulae vitae.

The Clay Mathematics Institute has offered a $ 1 million USD prize for the first correct proof, along with prizes for six other mathematical problems.

Some of the limitations of Diophantus ' notation are that he only had notation for one unknown and, when problems involved more than a single unknown, Diophantus was reduced to expressing " first unknown ", " second unknown ", etc.

The use of money as a medium of exchange and unit of account is necessary to solve the first two problems of economic calculation.

Reproductive endocrinologists deal primarily with problems of fertility and menstrual function — often training first in obstetrics.