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Page "Benzodiazepine" ¶ 50
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high and potency
Those who would suppress dangerous thoughts, credit ideas with high potency.
They were commonly classified on a spectrum of low potency to high potency, where potency referred to the ability of the drug to bind to dopamine receptors, and not to the effectiveness of the drug.
Digoxin from the foxglove plant is used clinically, whereas ouabain is used only experimentally due to its extremely high potency.
Estrogens are among the wide range of endocrine-disrupting compounds ( EDCs ) because they have high estrogenic potency.
An unusual feature of S. divinorum is its high potency ( dosage is in the microgram range ) and extremely disorienting effects, which often include " entity contact ", complete loss of reality-perception and user's experiencing their consciousness as being housed in different objects e. g. a pane of glass or a pencil.
Its strong potency in relation to that of morphine is largely due to its high lipophilicity, per the Meyer-Overton correlation.
Heavy: when a wave possesses a high concentration of water and releases it with great potency.
Because of its high potency, the smallest lorazepam tablet strength of 0. 5 mg is also a significant dose reduction ( in the UK, the smallest tablet strength is 1. 0 mg, which further accentuates this difficulty ).
It is a high-potency and an intermediate-acting benzodiazepine, and its uniqueness, advantages, and disadvantages are largely explained by its pharmacokinetic properties ( poor water and lipid solubility, high protein binding and anoxidative metabolism to a pharmacologically inactive glucuronide form ) and by its high relative potency ( lorazepam 1-2 mg is equal in effect to diazepam 10 to 20 mg ).
In Australia, the fatal envenomations are most often perpetrated by the largest species of this class of jellyfish Chironex fleckeri, owing to the high potency of the venom carried in their nematocysts.
For example, in 2007 it advertised " Surge Stix ", cigarette-like high potency caffeine delivery systems that, when snapped like a glow stick, supposedly deliver as much caffeine as five cans of Coca-Cola.
Though flunitrazepam is often cited as a date rape drug because of its high potency, strong effects and the ability to cause strong amnesia during its duration of action, investigations into its use as a date rape drug have contradicted popular belief.
Legally, the United States Food and Drug Administration allows a multivitamin to be called " high potency " if at least two-thirds of its nutrients have at least 100 percent of the DV.
In practice, " high potency " usually means substantially increased vitamins C and B, with some other enhanced vitamin and mineral levels, though some minerals may still be much less than DV.
Some drawbacks of desflurane are its low potency, its pungency and its high cost.
Based on the relatively high potency of 2C-T-21, it is likely that this compound binds quite strongly to the 5HT < sub > 2A </ sub > receptor target.
She has extremely high Speed and Magic potency, and can use both kinds of magic, but her attack spells are exclusively Ice-elemental and she is physically very weak.
It gradually became evident that the active material in purified extracts had astonishingly high potency in micrograms of DNA that could consummate the pneumococcal transformation in vitro.
* Diarylquinoline shows high potency in vitro
At this dosage its duration was very short and it produced few effects, however based on the research into the better characterized compound Ψ-DOM, the potency of Ψ-2C-T-4 is likely to be around 1 / 3 that of 2C-T-4 itself, so a more effective dosage of Ψ-2C-T-4 might be in the region of 20 – 60 mg ; however high doses such as this might well be associated with toxic side effects, and so extreme caution would be advised.
The high potency of dizocilpine makes its dosage more difficult to accurately control when compared to other similar drugs.

high and benzodiazepines
Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid ( GABA-A ), resulting in sedative, hypnotic ( sleep-inducing ), anxiolytic ( anti-anxiety ), anticonvulsant, and muscle relaxant properties ; also seen in the applied pharmacology of high doses of many shorter-acting benzodiazepines are amnesic-dissociative actions.
Most reports of disinhibition involve high doses of high-potency benzodiazepines.
Other benzodiazepines and zolpidem and zopiclone also were found in high numbers.
Many drivers had blood levels far exceeding the therapeutic dose range, suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.
Among benzodiazepines, lorazepam has a relatively high addictive potential.
The likelihood of dependence is relatively high with lorazepam compared to other benzodiazepines.
Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions.
Relative to other benzodiazepines, lorazepam is thought to have high affinity for GABA receptors, which may also explain its marked amnesic effects.
There is no specific antidote for bupropion ; treatment is supportive, and focuses on maintaining airway patency and controlling seizures with high dose intravenous benzodiazepines or barbiturates if seizures are refractory to benzodiazepines.
In a letter to the British Medical Journal, it was reported that a high proportion of parents referred for actual or threatened child abuse were taking drugs at the time, often a combination of benzodiazepines and tricyclic antidepressants.
In animals pretreated with high doses of benzodiazepines over several weeks, Flumazenil injection elicited symptoms of benzodiazepine withdrawal, including seizures.
Use of benzodiazepines such as nitrazepam in late pregnancy especially high doses may result in floppy infant syndrome.
Other benzodiazepines and zolpidem and zopiclone are also found in high numbers in suspected impaired drivers.
Many drivers have blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.
Use of benzodiazepines in late pregnancy especially high doses may result in floppy infant syndrome.
However, due to its slow rate of absorption ( the slowest of all benzodiazepines ) and its slow onset of action, oxazepam has a relatively low potential for abuse compared to some other benzodiazepines like temazepam, flunitrazepam, or triazolam, which have a high potential for abuse that is similar to barbiturate abuse potential.
The mind and judgment altering effects of Zaleplon are similar to those of many other benzodiazepines but the fast-acting nature and short half-life of the chemical mean that high dosages set on much more quickly and last for short periods of time ( usually from 45 to 60 minutes ).

high and triazolam
The post-operative nervous breakdown mentioned in the prologue and in other books by or about Roth was drawn from Roth's real-life experience of the temporary side-effects of a post-operative sedative ( triazolam ) which was later banned in several countries after discovery that the manufacturer had not published studies showing a high risk of short term psychiatric disturbance.
One drug which seems to be commonly associated with these problems is triazolam due to its high potency and ultra short half life but these effects can occur with other short acting hypnotic drugs.

high and are
For a brief period each year, the rays of the sun are warm enough to melt some of the snows piled a mile deep at the base of the headwalls, and then the pinnacles glisten in the daytime at high noon, and billions of gallons of water begin their slow seepage under the glaciers and across the rockstrewn hanging valleys on their long, meandering journey to the sea -- running east past the sky-carving massifs of Gurla Mandhata and Kemchenjunga, then turning south and curling down through the jungles of Assam, past the Khasi Hills, and into Bengal, past Sirinjani and Madaripur, until the hard water of the melting snows mingles with the soft drainage of fields and at length fans out to meld with the teeming salt depths of the Bay of Bengal.
No matter how earnest is our quest for guaranteed peace, we must maintain a high degree of military effectiveness at the same time we are engaged in negotiating the issue of arms reduction.
Around that statue in the green park where children play and lovers walk in twos and there is a glowing view of the whole city, in that park are the rows of marble busts of Garibaldi's fallen men, the ones who one day rushed out of the Porta San Pancrazio and, under fire all the way, up the long, straight narrow lane to take, then lose the high ground of the Villa Doria Pamphili.
Wine glass heels are to be found in both high and semi-heights.
In the tintable group are high and little heels, squared and oval throats, and shantung-like textures.
It is high time the United States began to realize that the God-given rights of men set forth in that document are applicable today to Katanga.
There are lots of jobs available for trained high school graduates, but not for the dropouts.
The armed forces of Taiwan are at a working strength of about 450,000, though a reserve potential twice that high is contemplated.
Its elimination would result in the saving of interest costs, heavy when short-term money rates are high, and in freedom from dependence on credit which is not always available when needed most.
The programs in infrared spectroscopy are undergoing reorientation toward wavelength standards in the far infrared, the application of infrared techniques to solid state studies, and increased emphasis on high resolution instrumentation.
The causes of the decline of the commuter railroads are many and complex -- high taxes, losses of revenue to Government subsidized highway and air carriers, to name but two.
These provisions are designed to reflect the differences in wealth and population among the States, with the objective that a vocationally handicapped person have access to needed services regardless of whether he resides in a State with a low or high per capita income or a sparsely or thickly populated State.
Our take-up machines and our twister-coners are undergoing important pilot plant testing for application with new high polymer yarns, in several fiber producing plants.
We are initiating research on the use of solid state materials for infrared detection using a method which will not require cooling of materials to attain high sensitivity.
Mr. Devey's new responsibilities are in addition to those of his present post as marketing manager of Sprague's Special Products Group, which manufactures a wide line of digital electronic components, packaged component assemblies, and high temperature magnet wires.
Because of this, it would appear inevitable that an increasing percentage of strategic missiles will seek self-protection in mobility -- at least until missile defenses are perfected which have an exceedingly high kill probability.
The reason that we are not going ahead full speed to develop high thrust-to-weight engines is that it would cost perhaps a billion dollars -- and you don't spend that sort of money if aircraft are obsolete.
Other natural features which can be of high interest are the forests, canyons, mountains, deserts, seacoast, beaches, sand dunes, waterfalls, springs, etcetera with which the area is blessed.
If we wait until children are in junior high or high school, we will never manage it.
Its figures are a half inch high and very easy to read, even into tenth gallons.
Rates in Greece and Finland are fairly high, actually the highest in Europe, and, surprisingly enough, they are also quite high in Ireland.

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