A review of the methods used in trials of antipsychotics, despite stating that the overall quality is " rather good ," reported issues with the selection of participants ( including that in schizophrenia trials up to 90 % of people who are generally suitable do not meet the elaborate inclusion and exclusion criteria, and that negative symptoms have not been properly assessed despite companies marketing the newer antipsychotics for these ); issues with the design of trials ( including pharmaceutical company funding of most of them, and inadequate experimental " blinding " so that trial participants could sometimes tell whether they were on placebo or not ); and issues with the assessment of outcomes ( including the use of a minimal reduction in scores to show " response ," lack of assessment of quality of life or recovery, a high rate of discontinuation, selective highlighting of favorable results in the abstracts of publications, and poor reporting of side-effects ).

Skeptics claim that there is a lack of a viable theory of the mechanism behind ESP, and that there are historical cases in which flaws have been discovered in the experimental design of parapsychological studies.

" He felt that his relative lack of experience left him without the necessary design tools to refine his vision, but the community liked the city hall enough to invite him back.

A major drawback of current gesture interaction solutions is the lack of support for two necessary user interface design principles, feedback and visibility ( or affordance ).

This is variously blamed on aggressive driving, insufficient driver training, old and unsafe cars, inferior road design and construction, and a lack of appreciation of the skill and responsibility required to safely operate a motor vehicle.

This design places an exceeding demand upon precision engineering due to the lack of pneumatics.

The number of losers — which may add up to the size and severity of poverty — can be unexpectedly large if the method and process of privatization and how it is implemented are seriously flawed ( e. g. lack of transparency leading to state-owned assets being appropriated at minuscule amounts by those with political connections, absence of regulatory institutions leading to transfer of monopoly rents from public to private sector, improper design and inadequate control of the privatization process leading to asset stripping.

Without at least one of these two pieces of information, we are not obviously justified in seeing design in such cases … he problem for the fine-tuning argument is that we lack both of the pieces that are needed to justify an inference of design.

In November 1974, Science for the People went public with their objections to the Boston XYY study in a press conference and a New Scientist article alleging inadequate informed consent, a lack of benefit ( since no specific treatment was available ) but substantial risk ( by stigmatization with a false stereotype ) to the subjects, and that the unblinded experimental design could not produce meaningful results regarding the subjects ' behavior.

) The lack of interoperability can be a consequence of a lack of attention to standardization during the design of a program.

Some cite design limitations and a lack of methodological rigor, while others assert that the quality is improving and that when suitable assessment criteria are applied, scientific evidence supports the therapeutic value of meditation.

Some cite design limitations and a lack of methodological rigor, while others assert that the quality is improving and that when suitable assessment criteria are applied, scientific evidence supports the therapeutic value of meditation.

The lack of complete and reliable information as to whom the credit for the design belongs, led to innumerable speculations.

Unable to produce the design himself due to lack of funding, he sold the patent in 1908 to William Henry Hoover who had Spangler's machine redesigned with a steel casing, casters, and attachments.

Still, there are many cases in which designers wish to sequence the steps of their models but lack the means to design clear diagrams.

Despite no widespread regulation, and even with a lack in many cases of national-level regulation, heraldry has remained rather consistent across Europe, where traditions alone have governed the design and use of arms.

* the lack of concern about security and authentication in the design, deployment and operation of some existing SCADA networks

The service was later dropped in 1965, owing to lack of cycle traffic and possibly the design.

A combination of hardware and operating-system software design considerations determine the symmetry ( or lack thereof ) in a given system.

Meanwhile Komarov and his fellow cosmonauts had their groups and assignments constantly revised and they became increasingly anxious about the lack of response to their concerns about the design and manufacture of space craft which had been raised in a letter to Leonid Brezhnev by Yuri Gagarin on their behalf.

** Federico Faggin, having finished the design of the 4004, became leader of the project from January 1971 until its successful completion in April 1972, after it had been suspended – for lack of progress – for about seven months.

The freeze on design in 1943 meant that the computer design would lack some innovations that soon became well-developed, notably the ability to store a program.

' Lower courts then set guidelines for identifying ' junk science ,' such as the 2005 opinion of United States Court of Appeals for the Seventh Circuit Judge Easterbrook, ' Positive reports about magnetic water treatment are not replicable ; this plus the lack of a physical explanation for any effects are hallmarks of junk science.

The American Psychiatric Association ( APA ) 2001 guidelines give the primary indications for ECT among patients with depression as a lack of response to, or intolerance of, antidepressant medications ; a good response to previous ECT ; and the need for a rapid and definitive response ( e. g. because of psychosis or a risk of suicide ).

The 2010 guidelines, from the American Heart Association has removed its recommendation for using atropine in pulseless electrical activity and asystole due to the lack of evidence for its use.

Because of the lack of guidelines on pin size, the pins themselves vary in size.

Like many 1960s purpose built resorts in the French Alps, Val Thorens suffered from a lack of architectural guidelines in the early days, leading to an over-dependence on concrete.

A Parenting Plan allows parents to avoid future conflicts arising from a lack of guidelines in dealing with responsibilities relating to the children.

Canadian guidelines discuss this lack of clarity and parenthetically point out that " heavy alcohol use " is defined by the National Institute on Alcohol Abuse and Alcoholism as five or more drinks per episode on five or more days during a 30 day period.

" Freeform " can also refer to online text-based role-playing games which lack rules or contain only basic guidelines, relying instead on the player's acting abilities and commitment to a good story.

It was highly critical of police, prosecutors and public servants in their approach to the prosecution of sex offences against minors, and their lack of specialist police resources and clear guidelines.

Some " purchases " made with a credit card of items that are viewed as cash are also considered to be cash advances in accordance with the credit card network's guidelines, thereby incurring the higher interest rate and the lack of the grace period.

Private schools are where the greatest and most successful innovations may flourish: loosely supervised by the State and complying with broad State guidelines, private schools enjoy the freedom which public schools lack and, therefore, may achieve great progress.

Since the article's subject is the film from which the screenshot is taken, no free equivalent can exist ; the image is of one single frame ( 1 / 24th of a second ) from the original work ( a feature-length film ), and is of a low resolution unsuited for commercial exploitation ; the content has been previously displayed publicly outside Wikipedia ; it meets the general and media-specific content guidelines for Wikipedia ; is used in at least one ( currently in four ) article on Wikipedia ; its presence will significantly increase readers ' understanding of the film ( the article's subject ) and its lack would impair that understanding ; it is used only in article space and its description page ( this page ) contains suitable information about the image's source, applicable copyright tag, and the names of and links to the articles in which it is used.

Inland from X Corps would be XIII Corps with Indian 5th Infantry Division ( with only one infantry brigade, Indian 29th Infantry Brigade, and two artillery regiments ) around Sidi Hamza ( about inland, the newly arrived New Zealand 2nd Division ( short one brigade because of lack of transport ) at Minqar Qaim ( on the escarpment inland ) and 1st Armoured Division in the open desert to the south.

A BBC News article about a lack of " mid-career volunteers " in their 20s provided a Generation X age range, which, in 2007, would suggest birth years that fall between 1962 and 1982.

This allows it to run in graphics mode even on platforms which don't have X Server because of lack of implementation or limited resources.

In XY mice, lack of the gene DAX1 on the X chromosome results in sterility, but in humans it causes adrenal hypoplasia congenita.

In these individuals with a repeat expansion greater than 200, there is methylation of the CGG repeat expansion and FMR1 promoter, leading to the silencing of the FMR1 gene and a lack of its product, fragile X mental retardation protein ( FMRP ).

* sons do not inherit X chromosomes from their fathers at all, any great-grandchild of the founder of a line may lack X chromosome DNA from that founder.

Genetic females ( with two X chromosomes ) with congenital adrenal hyperplasia lack an enzyme needed by the adrenal gland to make the hormones cortisol and aldosterone.

Due to a lack of coordination between Walker, General Edward Almond, Commander of the X Corps, and MacArthur's headquarters in Tokyo, a gap had opened between Eighth Army and X Corps as they moved close to the Chinese border.

F-Zero X is a futuristic racing video game where thirty pilots race on circuits inside plasma-powered hovercars in an intergalactic Grand Prix at speeds that can reach However, the game has been widely criticized for its lack of graphical detail.

The unwieldiness of this addressing format is believed by many to be one factor in the lack of success of X. 400.

The majority of VST plugins are available for Windows due to both Apple's proprietary Audio Unit software for OS X and the lack of information and patent encumbrances that make development difficult for Linux platforms.

Some felt this title suffered due to Marvel's lack of support for both this and Soldier X as neither title enjoyed house or trade support.

This group of young people, under the age of 35, frequently labelled Generations X and Y, have been noted for their lack of political interest and activity for the last two decades.

Problems compiling for the new version of Snow Leopard OS X, accumulating bug reports, and the lack of an OS X developer were reported as the reasons for this decision.

However, due to a continuing lack of a dedicated OS X developer, OS X 10. 6 + is not officially supported.

Users attribute the apparent lack of interest from TransGaming on Cedega to their focus on Cider, a similar MS-Win32, Wine-based API layer for Mac OS X systems, supported by Electronics Arts to bring their Windows native games to Mac.

( Despite the lack of bar, the unit would still be read as " X bar ," as opposed to " X prime.

Despite running for the same length of time as the Mark X ( 5 years ) the 420G sold in less than a third of the numbers: this lack of popularity and the increasing production of the XJ6 resulted in the 420G being run out of production in 1970.

In the framebuffer implementation this is MiniGLX, which initializes the DRM and provides some X APIs to the userland driver despite the lack of an X Server.