Traditionally, Bursa was famous for being the largest center of silk trade in the Byzantine and later the Ottoman empires, during the period of the lucrative Silk Road.

Constantinople was the largest and richest urban center in the Eastern Mediterranean Sea during the late Eastern Roman Empire, mostly as a result of its strategic position commanding the trade routes between the Aegean Sea and the Black Sea.

Many towns center around a " green ", such as the Litchfield Green, Lebanon Green ( the largest in the state ), and Wethersfield Green ( the oldest in the state ).

Guayaquil also became the largest shipbuilding center on the west coast of South America before the end of the colonial period.

The industry is concentrated mainly in Guayaquil, the largest industrial center, and in Quito where in recent years the industry has grown considerably, this city is also the largest business center of the country.

Egypt has long been the cultural and informational center of the Arab world, and Cairo is the region's largest publishing and broadcasting center.

The city is known as a center of manufacturing for recreational vehicles and accessories, the home of Goshen College, a small Mennonite liberal arts college, and home to the Elkhart County 4-H Fair, the second largest county fair in the United States.

The project stalled due to difficulties in the work, corruption and other issues, and in 1888, ran out of money when it reached San Pedro Sula, resulting in its growth into the nation's main industrial center and second largest city.

The team is based in the state's capital and largest city, Indianapolis, located in the center of the state.

The oblast's largest city and administrative center is Kaliningrad ( formerly known as Königsberg ), which has historical significance as both a major city of the historical state of Prussia and the capital of the former German province of East Prussia.

In the 9th and 10th centuries, the Budzistowo stronghold was the largest of several smaller ones in the Persante area, and as such is thought to have functioned as the center of the local Slavic Pomeranian subtribe.

Kansas City lies in the Midwestern United States, as well as near the geographic center of the country, at the confluence of the second largest river in the country, the Missouri River, and the Kansas River ( also known as the Kaw River ).

Though the election represented a victory for the center-right, personality conflicts and scandals within the two largest right of center parties – Latvian Way and the People's Party – prevented stable coalitions from forming.

It also constitutes the southernmost and the largest urban center of Legnicko-Głogowski Okręg Miedziowy with agglomeration of 448. 617 inhabitants.

The Lansing Metropolitan Area, colloquially referred to as " Mid-Michigan ", is an important center for educational, cultural, governmental, business, and high-tech manufacturing, including two medical schools, one veterinary school, two nursing schools, two law schools, including the nation's largest law school ( Thomas M. Cooley Law School ), a Big Ten Conference university ( Michigan State ), the Michigan State Capitol, the state Supreme Court and Court of Appeals, a federal court, the Library of Michigan and Historical Center, and headquarters of four national insurance companies.

The Sparrow Tower was finished January 2008 and includes but is not limited to: a dedicated pediatric emergency room ( the only one in the region ), the largest adult emergency room in the region, state-of-the-art operating rooms, a rooftop helipad, oncology center, heart and vascular center and orthopedic department.

The most massive collection of molecular clouds in the galaxy forms an asymmetrical ring around the galactic center at a radius of 120 parsecs ; the largest component of this ring is the Sagittarius B2 complex.

Pakistan's largest city, Karachi, which is also the country's industrial center, is more humid than Islamabad but gets significantly lesser rainfall.

Other notable shopping centers in the city include Galeria Malta, one of the largest in Central Europe, and the shops at the Hotel Bazar, a historical hotel and commercial center in the Old Town.

Enclosed within the great arc of the Carpathians lie the undulating plains and low hills of the Transylvanian Plateau -- the largest tableland in the country and the center of Romania.

The largest federal agencies contributing to research are NASA, National Science Foundation, Department of Health and Human Services, Department of Defense, and Department of Energy.

Some of HPES's largest clients include: American Airlines, Rolls-Royce plc, General Motors, Bank of America, FEMSA, Commonwealth Bank Kraft, United States Navy, the UK Ministry of Defence, IDA, Royal Dutch Shell, and NASA.

The federal government was the largest source of sponsored research, with the Department of Health and Human Services granting $ 255. 9 million, Department of Defense $ 97. 5 million, Department of Energy $ 65. 8 million, National Science Foundation $ 61. 4 million, and NASA $ 27. 4 million.

In a 2001 report, NASA found the ozone thinning over Antarctica had remained the same thickness for the previous three years, however in 2003 the ozone hole grew to its second largest size.

With the death of company founder and first CEO Willard Rockwell in 1978, and the stepping down of his son Willard Rockwell, Jr. in 1979 as the second CEO, Bob Anderson became CEO and led the company through the 1980s when it became the largest U. S. defense contractor and largest NASA contractor.

One of the air intakes of the 80 by 120 foot wind tunnel ( world's largest ), located at NASA Ames Research Center.

The 80 by 120 Foot Wind Tunnel at NASA Ames Research Center holds the distinction of being the largest wind tunnel test section in the world.

Pavilion Lake has the largest known freshwater stromatolites and has been researched by NASA as part of xenobiology research.

In the United States, the Department of Defense and the National Aeronautics and Space Administration ( NASA ) are the two largest consumers of aerospace technology and products.

The American flag painted on the building was the largest in the world when added in 1976 as part of United States Bicentennial celebrations, along with the star logo of the anniversary, later replaced by the NASA insignia in 1998.

After the closing of the JAMIC facility in Japan, the NASA Zero-G facility is the largest microgravity facility in the world.

NASA picture of Nendo, the largest of the Santa Cruz Islands

The NASA Space Shuttle used two Space Shuttle SRBs, which were the largest of their type in production service.

* NASA Photo: " STS085-713-070 Akimiski Island, Northwest Territory, Canada August 1997 Akimiski Island, a 2000-square-mile ( 5180 square kilometers ) uninhabited island, is the largest island in James Bay ( a southeasterly extension of Hudson Bay ).

By the time he left NASA in March 1996, he had directed NASA's largest and most visible program through twelve safe, successful missions, including the first three flights to the Russian Space Station, Mir.

By far the largest of these were elements of the United States Navy with some 3, 500 personnel, which was far larger than the NASA civil servant contingent.

* Dawn, a 2007 NASA mission that will study the largest of the Asteroid Belt's objects, the asteroid Vesta and the dwarf planet Ceres.

On March 4, 2000, the BA-2 project tested the largest liquid rocket engine built since the Saturn V. In October 2000, Beal Aerospace ceased operations citing a decision by NASA and the Department of Defense to commit themselves to the development of the competing government-financed EELV program.

Congressman Fattah is the lead Democrat responsible for funding some of the largest science agencies in the federal system ( NASA, NSF, Office of Science and Technology Policy ( OSTP ).

ISRO is amongst the six largest government space agencies in the world, along with NASA, RKA, ESA, CNSA and JAXA.

In 2000, it was the single largest recipient of higher education grants at $ 36 million Several grants were from the Department of Defense, plus $ 5 million from NASA for space radiation research.

The world's largest land-based rocket range, it is situated on a site located approximately 30 miles ( 50 km ) northeast of Fairbanks and is operated under contract to the NASA Wallops Flight Facility.

The largest non-DoD agency for which DCAA performs audits is NASA ( primarily since the same government contractors, especially on major programs, do substantial business with both DoD and NASA ).