The general acceptance of the idea of governmental ( i.e., societal ) responsibility for the economic well-being of the American people is surely one of the two most significant watersheds in American constitutional history.

As symptomatic of the common man's malaise, he is most significant: a liberal and a Catholic, elected by the skin of his teeth.

Of all the Whig tracts written in support of the Succession, The Crisis is perhaps the most significant.

One of the most significant advancements in design of plastics signs is the so-called trans-illuminated billboard, now being produced by several large sign manufacturers such as Advance Neon Sign Co., Los Angeles, and Industrial Electric Inc., New Orleans, La..

Other than this very significant result, most of the information now available about the radio emission of the planets is restricted to the intensity of the radiation.

Statistically, the most significant data have been collected from the sensors on 1958 Alpha ( Explorer 1 ), 1958 Delta 2 ( Sputnik 3 ), and 1959 Eta ( Vanguard 3 ).

Such conversation quickly reveals an ethically significant ambivalence in the self-images held by most realtors.

Aristotle not only studied almost every subject possible at the time, but made significant contributions to most of them.

The group of elements is more diverse than the lanthanides and therefore it was not until 1945 that Glenn T. Seaborg proposed the most significant change to Mendeleev's periodic table, by introducing the actinides.

Alpha, both as a symbol and term, is used to refer to or describe a variety of things, including the first or most significant occurrence of something.

Among Poirot's most significant personal attributes is the sensitivity of his stomach:

In the Southwest, mountain ranges, rivers and, most obviously, the Grand Canyon can be significant barriers for human communities, likely reducing the frequency of contact with other groups.

The lives of numerous abbots make up a significant contribution to Christian hagiography, one of the most well-known being the Life of St. Benedict of Nursia by St. Gregory the Great.

The basic design remained unchanged for centuries, with the most significant changes being to the overall proportions, and a move from wooden stocks to those of iron.

Historic Swabia was eventually replaced by today's Baden-Württemberg, but it had been the most significant territory of mediaeval Alamannia, comprising all Germania Superior and territory east to Bavaria.

Hence, if a dish contains significant amounts of any of these ingredients, it has most likely been Americanized.

The most significant moderate proposal was the Fourteenth Amendment, also written by Trumbull.

The most significant of these is the story about Ambrosius, Vortigern, and the two dragons beneath Dinas Emrys, " Fortress of Ambrosius " in Chapters 40 – 42.

On the subject of charity Andrew Carnegie's actions diverged in the most significant and complex manner from Herbert Spencer's philosophies.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Naamani Tarkow has written: " If one is to make sweeping statements, one may say that, save Magna Carta ( more truly, its implications ), the Act of Settlement is probably the most significant statute in English history ".

Dunn, who was tied for the major league lead with 32 home runs, was expected to provide a significant boost to an offense that has struggled to score runs for most of the season.

Sunday family dinner is considered the most significant meal of the week, whose highlights often include asado or pasta.

From the 1960s through the 1980s, " by far the most significant developments in the design and construction of acoustic guitars " were made by the Ovation Guitar Company.

Moreover, these combination analgesics can often result in significant adverse events, including accidental overdoses, most often due to confusion which arises from the multiple ( and often non-acting ) components of these combinations.

This species of flea is the primary Vector ( epidemiology ) | vector for the transmission of Yersinia pestis the organism responsible for bubonic plague in most plague epidemic s in Asia, Africa, and South America.

Since human plague is rare in most parts of the world, there is no need to vaccinate people other than those at particularly high risk of exposure.

During its initial, and most deadly waves, approximately 200, 000 people were killed by the plague, and, by the 15th century, Cairo's population had been reduced to between 150, 000 and 300, 000.

Other suspected sources of the plague were cats and dogs, most of which the Lord Mayor of London at the time had caused to be exterminated.

Also, most plague cases were found in the suburbs of the city and not in the centre of London that was affected by the Fire.

It is most likely that this was the same plague that struck Rome during Marcus Aurelius ’ reign.

It was also hit by frequent outbreaks of plague, and by floods, particularly that of 1736, which destroyed most of the suburban buildings.

Clement is most notable as the Pope who reigned during the time of the Black Death ( 1348 – 1350 ), during which he granted remission of sins to all that died of the plague.

Of all the states in the region, Norway suffered the most from this plague.

Indeed, Claire Tomalin writes that ' the most notable fact about Pepys's plague year is that to him it was one of the happiest of his life.

Following a plague epidemic in 1914, the authorities forced most of the African population out of old neighborhoods, or " Plateau ", and into a new quarter, called Médina, separated from it by a " sanitary cordon ".

Compounding Edward's difficulties were the deaths of his most trusted men, some from the 1361 – 62 recurrence of the plague.

Messina was most likely the harbour at which the Black Death entered Europe: the plague was brought by Genoese ships coming from Caffa in the Crimea.

Having passed the time during the plague composing prose pamphlets ( including a continuation of Thomas Nashe's Pierce Penniless ), he returned to drama with great energy, producing close to a score of plays for several companies and in several genres, most notably city comedy and revenge tragedy.

The most apparent symptom of pneumonic plague is coughing, often with hemoptysis ( coughing up blood ).

The People's Republic of China has eradicated the pneumonic plague from most parts of the country, but still reports occasional cases in remote Western areas where the disease is carried by rats and the marmots that live across the Himalayan plateau.

A 2006 WHO report from an international meeting on plague cited a Chinese government disease expert as saying that most cases of the plague in China's northwest occur when hunters are contaminated while skinning infected animals.

He said August 1 that most of the infections are bubonic plague, with four cases of pneumonic plague.

The outraged goddess cursed the country with plague and famine ; in order to put an end to the calamity, the inhabitants of Patrae were instructed by the oracle of Delphi to sacrifice both lovers to the goddess and, from then on, to sacrifice the handsomest young man and the most beautiful girl of the city each year, until a new strange deity is introduced in Patrae.

In 1574, 1625, 1636, and 1673, Gouda suffered from deadly plague epidemics, of which the last one was the most severe: 2995 persons died, constituting 20 % of its population.