A 2006 Cochrane Collaboration review of controlled trials of antipsychotics in old age dementia reported that one or two of the drugs showed a modest benefit compared to placebo in managing aggression or psychosis, but that this was combined with a significant increase in serious adverse events.

The 2011 figures show an increase of some 64, 000 speakers compared to the 2006 figures to 714, 136, with significant increases in the Autonomous Community but a slight drop in the Northern Basque Country to 51, 100, overall amounting to an increase to 27 % of all inhabitants of Basque provinces ( 2, 648, 998 in total ).

The 2005 census showed a significant increase, as this figure reached 230, 600 inhabitants.

These tests met with “ partial success ” in the gathering of data, and led, therefore, to a significant increase in research dollars in fiscal year 1962 to conduct additional research in these areas.

Intel's successor to the P5 architecture, P6, added superscalar capabilities to its floating point features, and therefore afforded a significant increase in floating point instruction performance.

In the 1980s and 1990s there was a significant increase in passenger transport on the roads in the Czech Republic, which was associated with a sharp increase in the accident rate.

Breeding experiments in Germany with poodles, coyotes, and later on with the resulting dog-coyote hybrids showed that, unlike wolfdogs, coydogs exhibit a decrease in fertility, significant communication problems, and an increase of genetic diseases after three generations of interbreeding.

The replacement of the Roman saddle by variants on the Scythian model, with pommel and cantle, was also a significant factor as was the adoption of stirrups and the concomitant increase in stability of the rider's seat.

By contrast, loop diuretics promote a significant increase calcium excretion.

In a follow-up study, Swiss children showed a significant increase in sharing between the ages of 3 and 8.

Although the administration made progress on such issues as taking state responsibility for past human rights cases and supporting human rights in international fora, it failed to show significant advances on combating impunity in past human rights cases, military reforms, a fiscal pact to help finance peace implementation, and legislation to increase political participation.

These factors can also cause hydrocodone and related drugs to have a threshold effect, cause significant lengthening or shortening of the duration of effects in the absence of tolerance, and increase or decrease the de facto conversion ratio between hydrocodone and other drugs like morphine, hydromorphone, and synthetics like levorphanol and methadone.

During the period 1813-1913, there was a significant increase in worker wages.

The results showed that, unlike wolf-dog hybrids, jackal-dog hybrids show a decrease in fertility, significant communication problems, and an increase of genetic disorders after three generations of interbreeding, much like coydogs.

The lack of manpower also led to a significant increase in the number of " barbarians " in the Byzantine armies after the early 540s.

During his reign, there was a significant increase in the size of the Mughal Empire, half a dozen rebellions were crushed, prisoners of war were released, and the work of his father, Akbar, continued to flourish.

The baby boom saw a significant increase in sales for Jello.

Since the war, Kuwait, with the help of the United States and other allies, has made significant efforts to increase the size and modernity of their armed forces.

" The authors further report a " significant increase in the speed of mathematical processing, with no reduction in accuracy " following the administration of a 300 mg dose.

The study also found a small, but statistically significant, increase in unemployment for adults aged 20 – 24.

There is a very significant increase of Web users in Malawi.

* 1980s-1990s: EPZ expanded and led to a significant increase in foreign direct investment ( FDI ) and tourism.

Palin's travel programmes are responsible for a phenomenon termed the " Palin effect ": areas of the world that he has visited suddenly become popular tourist attractions – for example, the significant increase in the number of tourists interested in Peru after Palin visited Machu Picchu.

Individual crocheters work yarn with a loose or a tight hold and, if unmeasured, these differences can lead to significant size changes in finished garments that have the same number of stitches.

Despite its small size ( roughly from its northernmost to southernmost points ), there is significant variation in mean temperature and amount of snowfall between Sussex County and New Castle County.

Eritrea maintains a military force on its border with Ethiopia roughly equal in size to Ethiopia's force, which has required a general mobilization of a significant portion of the population.

The most significant of these adaptations are 1. bipedalism, 2. increased brain size, 3. lengthened ontogeny ( gestation and infancy ), 4. decreased sexual dimorphism.

However, the differences between the structure of human brains and those of other apes may be even more significant than differences in size.

If a significant amount of greens work is required in a film, then the Greens may be an identifiable sub-department, with its own team-often of a size numbering double figures-and hierarchy ( eg.

The council convoked by Callistus II was significant in size: three hundred bishops and more than six hundred abbots assembled at Rome in March, 1123 ; Callistus presided in person.

" since a sufficiently advanced civilization could potentially be observable over a significant fraction of the size of the observable universe.

Though the idea that brain size is unrelated to race and intelligence was popularized in the 1980s, studies continue to show significant correlations.

The famine was by far the most significant turning point in the demographics of the country, as not only did Ireland's population not grow for the next century, it continued a slow decline, the result of which is that the Republic of Ireland has a significantly smaller population today than would be expected for a European country of its size.

Perhaps the most significant difference between the Contemporary City and the Radiant City is that the latter abandons the class-based stratification of the former ; housing is now assigned according to family size, not economic position.

In 2007 the country had about 200 call centres, including 30 of significant size, that employ a total of over 18, 000 people.

However, the data set post-1985 ( which is widely regarded as a turning point in the Ganzfeld experiments ) remains statistically significant and has an inclining effect size regression.

It analyzed the results of 380 studies ; the authors reported an overall positive effect size that was statistically significant but very small relative to the sample size and could be explained by publication bias.

However, the study also found that when a small number of the highest-quality studies from one laboratory were analyzed, the effect size was not significant.

He also implemented many procedural reforms, to make Parliament and the Liberal caucus meetings run more efficiently, significantly expanded the size and role of the Prime Minister's office, and substantially expanded the welfare state, with the establishment of new programmes, and significant improvements in existing ones, with welfare payments to the aged, the young, and the underprivileged greatly expanded in an attempt to bring about a European-style social democracy in Canada.

Belgrade, with its population of 1, 574, 050, is the largest city in the two nations: and the only one of significant size.

Due to the limited size of the SNO detector in comparison with Super-K the low cosmic ray neutrino signal is not statistically significant at neutrino energies below 1 GeV.

The latter resulted in the abolition of the Council and a significant increase in the size of Parliament in December 2008.

Transposition can create phenotypically significant mutations and alter the cell's genome size.

To produce significant diffraction, the spacing between the scatterers and the wavelength of the impinging wave should be similar in size.

Uniquely, the size of the displacement was encoded in its most significant bits: 0, 10 and 11 preceded 7 -, 14-and 30-bit signed displacements.