Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.

Thus the reverse procedure, though originally uncommon, enabled northern analysis to evolve into gene expression profiling, in which many ( possibly all ) of the genes in an organism may have their expression monitored.

Thus, Xenopus is the only vertebrate model system that allows for high-throughput in vivo analyses of gene function and high-throughput biochemistry.

Thus, a non-mutant MECP2 gene is necessary for a Rett's-affected embryo to survive in most cases, and the embryo, male or female, must have another X chromosome.

Thus, each gene also has a corresponding homologue, which may exist in different forms: the variant forms are called alleles.

Thus, in order for gene transcription to be activated, the cell must encounter signaling molecules secreted by other cells in its environment.

Thus, unique combinations of pair-rule gene expression create spatial domains along the anterior-posterior axis to set up each of the 14 individual segments.

Thus, in the evolution of the complex pigmentation phenotype, the yellow pigment gene evolved enhancers responsive to the wingless signal and wingless expression evolved at new locations to produce novel wing patterns.

Thus, a method for identifying those few successful gene uptake events is necessary.

Thus if the parents are closely related ( in-breeding ) the probability of both having inherited the same gene is increased and as a result the probability of the children showing the recessive trait is increased as well.

Thus, conditional temperature-sensitive mutations in the Drosophila melanogaster gene for NSF lead to a comatose behaviour at the restrictive temperature ( and hence the gene is called comatose ), presumably because neuronal functions are blocked.

Thus, viral gene expression can occur and new virus particles can be generated.

Thus, the ongoing intensive reciprocal gene flow was accompanied by the gradual dissolution of the Asiatic genetic component.

Thus it accumulates mutations faster than a functional single-copy gene, over generations of organisms.

Thus we accumulate damages to our body as we age and harbor late-onset diseases such as Huntington's disease which have minimum impact on the evolutionary success of our gene overlords.

Thus, a novel mechanism for regulation of gene expression, the epigenetic silencing of genes by miRNAs, was discovered.

Thus IEGs are distinct from " late response " genes, which can only be activated later, following the synthesis of early response gene products.

Thus the PAX6 gene is highly conserved across evolutionary lineages.

Thus, while mRNA gene expression data and proteomic analyses do not tell the whole story of what might be happening in a cell, metabolic profiling can give an instantaneous snapshot of the physiology of that cell.

Thus, in the nucleotide model proposed by Dickinson, AG and Outram in 1979, the life cycle of the scrapie agent included a stage where the genome was bound to host protein, probably a multimeric protein complex ( now commonly known as a Prion ), derived from the sinc gene.

Thus, despite being designated the number 2 interleukin, it was the first interleukin molecule, receptor, and gene to be discovered.

Thus ERK1 and ERK2 both correspond to the Drosophila kinase rolled, JNK1, JNK2 and JNK3 are all orthologous to the gene basket in Drosophila.

Thus, the plasmid, with its replicator gene, is not prevented from moving out of the bacillus into neighboring human nerves where it replicates, damaging those nerves and causing the tuberculoid HD clinical picture.

Thus, the avant-garde choreographers have extended the scope of materials available for dance composition.

Thus, many a creativity-oriented aspirant for a career in architecture, drama, or journalism, resigns himself to a real estate business ; ;

Thus a new pattern of days began to develop, for Granny Albright did not die.

Thus, the need for the B-70 as a strategic weapon system is doubtful.

Thus, you avoid headaches when an employee wants off for his fourth cousin's funeral.

Thus it was that Barco, apprehended for mere larceny, now began to suspect that one or another of his murders had been uncovered.

Thus, the dotted line shown in figure 4 was taken as typical for the temperature distribution for all blowing rates.

Thus, for aqueous media, we can think of the idealized organic active as an oleophilic or hydrophobic surface-active agent, and of an idealized builder as a oleophobic or hydrophilic surface-active agent.

Thus, an enemy would probably use this weapon for attack on static population centers such as large cities.

Thus, the alignment of the `` dots '' and `` tips '', respectively, indicate individual variability of the 21 growth centers of each child with respect to the mean values for these boys and girls.

Thus if E is sufficiently small, there can be only one intersection of C and Af near Q, for if there were more than one intersection for every E then the difference between C and Af near Q would not be a monotone function.

Thus the multiplicity of Af for a given T must be an even number.

Thus, although the agenda of external assistance in the economic sphere are cumulative, and many of the policies suggested for nations in the earlier stages remain relevant, the basic purpose of American economic policy during the later stages of development should be to assure that movement into a stage of self-sustaining growth is not prevented by lack of foreign exchange.

Thus the lack of effective recognition of the responsibilities involved in caring for two babies showed signs of becoming a disabling problem.

Thus, the writer decided to hold one experimental section of the functional preparation for marriage course in the spring semester of 1960 exclusively for persons already married -- that is, prerequisite: `` marriage ''.

Thus the films seen as they came in ( coordinated for the regular sections ), were often out of context.

Thus, when more than one distinct form leads to a particular cell in the X-region, a chain of information cells must be created to accommodate the forms, one cell in the chain for each form.

Thus in his friends are stranger than his sisters' strong stresses are normal for his and sisters', but in his friends are stranger than his sisters strong stresses are normal for friends and sisters.

Thus in Mary wrote an account of the trip first strong stress on Mary marks Mary as the first in a series of people who wrote accounts of the trip, strong stress on wrote marks the writing as the first of a series of actions of Mary's concerned with an account of her trip ( about which she may later have made speeches, for example ), and strong stress on trip makes the trip the first of a series of subjects about which Mary wrote accounts.

Thus his persistence values for some stem frequencies per meaning are: stem identical in 8 languages, 100% ; ;

Thus while his theory or technique may not be oversubscribed, it is commonplace for bullish and bearish positions to become temporarily over-subscribed.