When South America became attached to North America creating the Isthmus of Panama, the Arctic region cooled due to the strengthening of the Humboldt and Gulf Stream currents, eventually leading to the glaciations of the Pleistocene ice age, the current interglacial of which is the Holocene Epoch.

When the Panama Railroad Company was founded in 1849, Stephens was chosen to be Vice President.

When he crossed to the mainland in an attempt to take Panama, his open rebellion against the Spanish crown came to an end.

When the military in Panama could not agree on a site, Arnold was ordered back to Washington D. C. to resolve the dispute and was en route by ship when the United States declared war on Germany.

When the United States shifted its interests to Panama, Zelaya negotiated with Germany ( who happened to be in the middle of a cold war with the U. S over Caribbean ports ) and Japan in an unsuccessful effort to have a canal constructed in his state.

When re-united with Panama, the gunas with the support of the Panamanian government, created an autonomous territory called Guna district of Yala indigenous and ensuring security of the population and culture Guna.

When the California gold rush began in 1848, traffic through Panama greatly increased, and New Granada agreed to allow the Panama Railroad to be constructed by American interests.

When the revolution came in November 1903, the United States intervened to protect the rebels, who succeeded in taking over the province, declaring it independent as the Republic of Panama.

When they refused, he tried again to persuade the governments of the Holy Roman Empire and the Dutch Republic to establish a colony in Panama, but failed in both cases.

When the effectiveness of this procedure was realized, fumigation was extended to all of Panama.

When, after 1824, the old Democratic-Republican party split into factions, he followed Andrew Jackson and Martin Van Buren in opposing the Panama Congress and the policy of making Federal appropriations for internal improvements.

When the United States took over the wide Canal Zone and resumed building the canal on 4 May 1904 almost two years were spent in infra-structure preparation, mosquito abatement ( the newly discovered vector spreading Yellow fever and Malaria ), Panama Railroad improvements and planning before the work got up to full speed.

When he wasn ’ t trapping rats and squirrels in California, Blue directed mosquito eradication efforts to control yellow fever in New Orleans ( 1905 ), at the Jamestown Exposition ( 1907 ), and in Honolulu ( 1911 ), to help Hawaii prepare for traffic to follow the opening of the new Panama Canal.

When the New Panama Canal Company sprang up back in his native France, Bunau-Varilla sailed home, having purchased a large amount of stock.

When the Japanese occupied Manila, Parsons was careful to speak only Spanish and convinced the Japanese he was a citizen of Panama.

When José Domingo de Obaldía assumed the presidency since 1908, began a policy of protecting the dignity and respect for the interests of the Panamanian nation in relations between Panama and the United States, also reinforcing the country's security from promulgation of Decree No. 18 of January 26, 1909, for the establishment of the National Secret Police.

When Panama broke away from Spain and joined Colombia in the early 19th Century, the Ngäbe remained in the mountains.

When General MacArthur was Chief of Staff, he placed Brown in charge of the Panama Canal district.

When the national team returned to Honduras from Panama, the directory of the soccer federation under Callejas ’ control once again was pressed by a sector of the media, to force Chelato out.

When the squadron was relocated to Howard Field in the Panama Canal Zone in January 1945 to transition to P-38 Lightning fighters, its pilots were soon banned from the Officers Club for rowdiness and vandalism.

When it hit near Panama City, Florida as the equivalence of a Category 3 hurricane on the Saffir-Simpson scale, it caused at least 23 deaths, including five when a lighthouse was destroyed.

When they were closer and he saw that one was a woman, he was more puzzled than ever.

When the meal was ready, he told Jones to wash up, and going into the front room, woke the girl.

When they reached their neighbor's house, Pamela said a few polite words to Grace and kissed Melissa lightly on the forehead, the impulse prompted by a stray thought -- of the type to which she was frequently subject these days -- that they might never see one another again.

When he regained consciousness he was in Lord's house, in the office of Doctor Lord, the deputy's deceased father.

When it was followed by a second, whining even closer, Cobb swerved sharply aside into a depression.

When the sea was visible ahead of them, the relief was as great as if the sun had come out.

When she appeared at the store to help out for a few hours even my looking at her was surreptitious lest my Uncle notice it.

When our eyes met the air was filled with an unuttered message of `` Me, too ''.

`` When I was in college '', I grinned, `` I remember a poem I had to read in my lit class.

When they got to Shillong, in Assam, he was happy.

`` When I came up, damnit, I thought I was going down.

When he awoke in the mornings, she was in his mind and he could hardly wait to get to school to be near her in the flesh.

When he came back to the schoolhouse, his mind was made up.

When he finally left the sinister mansion on Perdido Street, he was carried out in a coroner's basket.

When he was eight he began violin lessons.

When the possibility that he had not given reconsideration to so weighty a decision seemed to disconcert his questioners, Mr. Eisenhower was known to make his characteristic statement to the press that he was not going to talk about the matter any more.

When he was stripped, deloused and numbered by his guards, his much-thumbed sketchbook was seized and thrown on a pile of prisoners' goods to be confiscated.

When her right hand was incapacitated by the rheumatism, Sadie learned to write with her left hand.

When Harold Arlen returned to California in the winter of 1944, it was to take up again a collaboration with Johnny Mercer, begun some years before.

When he was fifteen John H. Mercer turned out his first song, a jazzy little thing he called `` Sister Susie, Strut Your Stuff ''.

When he heard that Paul Whiteman was looking for singers to replace the Rhythm Boys, Mercer applied and got the job, `` not for my voice, I'm sure, but because I could write songs and material generally ''.