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When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor ( GEF ).

Edit
Promote Demote Fragment Fix

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When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor ( GEF ).

Edit
Promote Demote Fragment Fix

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