While rheumatic fever since the advent of routine penicillin administration for Strep throat has become less common in developed countries, in the older generation and in much of the less-developed world, valvular disease ( including mitral valve prolapse, reinfection in the form of valvular endocarditis, and valve rupture ) from undertreated rheumatic fever continues to be a problem.

While rheumatic fever since the advent of routine penicillin administration for Strep throat has become less common in developed countries, in the older generation and in much of the less-developed world, valvular disease ( including mitral valve prolapse, reinfection in the form of valvular endocarditis, and valve rupture ) from undertreated rheumatic fever continues to be a problem.

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