Without diagnosis and treatment, the infection can be fatal in one to six days ; mortality in untreated cases is approximately 100 %.

Without treatment, an acute attack of gout usually resolves in five to seven days.

Without treatment, episodes of acute gout may develop into chronic gout with destruction of joint surfaces, joint deformity, and painless tophi.

Without timely treatment, these new blood vessels can bleed, cloud vision, and destroy the retina.

Without special treatment after circulation is restarted, full recovery of the brain after more than 3 minutes of clinical death at normal body temperature is rare.

Without treatment, the disease is invariably fatal, with progressive mental deterioration leading to coma and death.

Without treatment, about 12-13 % of patients will spontaneously improve over time, 40-50 % will get worse and the rest will be relatively stable.

Without treatment, symptoms may worsen, leading ( in extreme cases ) to suicide attempts.

Without renouncing its " Third-worldism " position, it extended the treatment of its subjects, concentrating on international economic and monetary problems, strategic relations, the Middle-East conflict, etc.

Without effective water treatment, a cooling water system can suffer from scale formation, corrosion and fouling and may become a breeding ground for harmful bacteria such as those that cause Legionnaires ' Disease.

Without treatment, the individual with schizoaffective disorder may further worsen in their abnormal emotions and delusional thought processes.

Without urgent treatment these result in sudden death.

Without necessarily receiving great remuneration ( pay differentials under Zhivkov were within the 5: 1 range, with the overwhelming majority of salaries being within the 3: 1 range ), Party members and DS informers received very significant perquisites which involved access to accommodation, luxury imported goods, hard currency, the ability to travel abroad, superior medical and dental treatment and unhindered entry to higher education for their children.

Without insight into what the problem is, it is much harder for behavioral therapy to be the key to the successful treatment of compulsive hoarders.

Without treatment, mortality in infants with galactosemia is about 75 %.

Without treatment, persons afflicted often appear to walk on their ankles, or on the sides of their feet.

Through its breakthrough price offers to developing country governments and leading NGOs such as Doctors Without Borders ( MSF ) and Oxfam, along with its keen participation in PEPFAR, the Global Fund, the Clinton Foundation's HIV / AIDS Initiative and other major donor programs fighting HIV / AIDS in Africa and elsewhere in the resource-poor world, Cipla has played an unparalleled leadership role in ensuring access to antiretroviral treatment ( ART ) rose from under 10, 000 on the entire African continent at the time of its $ 350 per patient per year offer in 2001, to over 8 million in the developing world by 2012.

Without treatment, children often die in the first decade of life.

Without much exchange with the ocean outside the Island, the Lake water quality is threatened by runoff from human activities in the surrounding watershed, especially from sewage treatment plants and septic tanks, ocean going ships and small craft plying the lake system.

Without treatment, the disease is often fatal.

Without treatment death usually occurs due to heart failure and respiratory weakness.

Without treatment the disease is particularly lethal in infants and young children.

Without treatment, mortality may approach 1 %, usually within six weeks of onset.

Without treatment, kidney damage occurs and death in the more severe cases.

* Sea Without Shore: A Manual of the Sufi Path, an extensive treatment of the science of tasawwuf.

Without appropriate intervention, these children lag behind their peers.

Without support from the nobility, the practice gradually shifted toward abandoned children.

Without having the opportunity to be exposed to other cultures, it impedes on how Black children will function later on as adults trying to live a normal life.

Without any living children of his own, Maigret nevertheless demonstrates fondness for children, treating them with kindness and patience, and often indulging them.

* Betty Mahmoody, lecturer, advocate for the rights of women and children, and co-author of the Pulitzer Prize-nominated, best-selling book, Not Without My Daughter: Escape from Iran.

Without a market for their produce, many farmers were glad to exchange chickens, eggs, ham, milk, etc., for meals for their children.

Without the further expense and responsibility of a monument above the grave, the catacombs have afforded a secure, dignified and exclusive resting place for the well-to-do, particularly the unmarried, the childless and young children of those without family plots or mausolea elsewhere.

" Without interfering in any affairs, despite the many attempts by those who would dishonestly use her name, she lives only for me, dedicated to bringing up our children.

Without warning his youngest brother Felix, who had been in Tasmania since the early 1830s, reappeared in England accompanied by eight of his children, having abandoned his wife and youngest child in Australia.

Without the shield, the ozone layer will naturally return and the Aldeans will be able to have children once again.

Without consulting the Connecticut colonists, Massachusetts, in August, sent a punitive expedition of ninety men under John Endicott to Block Island with instructions to kill every Niantic warrior and capture the woman and children, who would be valuable as slaves.

Without the support of her husband, Mrs Darby supported herself and the five children born of the marriage by starting a school for young girls ( where Mary taught by her 14th birthday ).

Throughout his 1935 travel book Journey Without Maps, British author Graham Greene uses " piccaninny " as a general term for African children.

* A Life Without Pain The website of a documentary about three children who have CIP or similar diseases

Some accused CBS of being irresponsible in showing the movie during the primetime hours, when some children were still out trick-or-treating, but very few occasions have happened since Orson Welles ' 1938 The War of the Worlds radio broadcast that so many people have been taken in by a production such as Without Warning.

Without children in it, her house seems like a prison to her.

Without using recursion or corecursion, one may traverse a tree by starting at the root node, placing the child nodes in a data structure, then removing the nodes in the data structure in turn and iterating over its children.

Without the subsidy, some parents could not afford the higher fees and their children would be forced to leave the ESF system.

Early persecuted heroines were often driven from their husbands ' homes by the persecutations of their mothers-in-law, whose motives are seldom delineated, and whose accusations are of the heroines ' having borne monstrous children, or committed infanticide, or practicing witchcraft — all of which appear in such fairy tales as The Girl Without Hands and many others ; but, as time progresses, a new persecutor appeared: a courtier who was rejected by the woman or whose ambition requires her removal, and who accuses her of adultery or high treason, motifs not duplicated in fairy tales, and while he never eliminates the mother-in-law, many romances such as Valentine and Orson have later variants that change from the mother-in-law to the courtier, whereas a more recent version never goes back.

Without the presence of Bill Bixby, Susan Clark and the three children, the film was not a success.

Without a proper diet children can lack proper brain development and may suffer from malnutrition.