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In 2007, the first structure of a human GPCR was solved (, ).< ref name =" Rasmussen_2007 "> This was followed immediately by a higher resolution structure of the same receptor ().< ref name =" Cherezov_2007 ">< ref name =" Rosenbaum_2007 "> This human β < sub > 2 </ sub >- adrenergic receptor GPCR structure, proved to be highly similar to the bovine rhodopsin in terms of the relative orientation of the seven-transmembrane helices.
ICt < font size ="- 1 ">< sub > 50 </ sub ></ font > is the dose that will cause incapacitation rather than death.
Both morphine and its hydrated form, C < font size ="- 1 ">< sub > 17 </ sub ></ font > H < font size ="- 1 ">< sub > 19 </ sub ></ font > NO < font size ="- 1 ">< sub > 3 </ sub ></ font > H < font size ="- 1 ">< sub > 2 </ sub ></ font > O, are sparingly soluble in water.

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< table >< tr valign =" top ">< td width =" 25 %">
< tr bgcolor ="# FFFFFF ">< td > 1 < td > Stuart Donaldson < td >< td > 6 June 1856 < td > 25 August 1856
< tr bgcolor ="# FFFFFF ">< td > 2 < td > Charles Cowper < td >< td > 26 August 1856 < td > 2 October 1856
< tr bgcolor ="# FFFFFF ">< td > 3 < td > Henry Parker < td >< td > 3 October 1856 < td > 7 September 1857
< tr bgcolor ="# FFFFFF ">< td >-< td > Charles Cowper ( 2nd time )< td >< td > 7 September 1857 < td > 26 October 1859
< tr bgcolor ="# FFFFFF ">< td > 4 < td > William Forster < td >< td > 27 October 1859 < td > 8 March 1860
< tr bgcolor ="# FFFFFF ">< td > 5 < td > John Robertson < td >< td > 9 March 1860 < td > 9 January 1861
< tr bgcolor ="# FFFFFF ">< td >-< td > Charles Cowper ( 3rd time )< td >< td > 10 January 1861 < td > 15 October 1863
< tr bgcolor ="# FFFFFF ">< td > 6 < td > James Martin < td >< td > 16 October 1863 < td > 2 February 1865
< tr bgcolor ="# FFFFFF ">< td >-< td > Charles Cowper ( 4th time )< td >< td > 3 February 1865 < td > 21 January 1866
< tr bgcolor ="# FFFFFF ">< td >-< td > James Martin ( 2nd time )< td >< td > 22 January 1866 < td > 26 October 1868
< tr bgcolor ="# FFFFFF ">< td >-< td > John Robertson ( 2nd time )< td >< td > 27 October 1868 < td > 12 January 1870
< tr bgcolor ="# FFFFFF ">< td >-< td > Charles Cowper ( 5th time )< td >< td > 13 January 1870 < td > 15 December 1870
< tr bgcolor ="# FFFFFF ">< td >-< td > Sir James Martin ( 3rd time )< td >< td > 16 December 1870 < td > 13 May 1872
< tr bgcolor ="# FFFFFF ">< td > 7 < td > Henry Parkes < td >< td > 14 May 1872 < td > 8 February 1875
< tr bgcolor ="# FFFFFF ">< td >-< td > John Robertson ( 3rd time )< td >< td > 9 February 1875 < td > 21 March 1877
< tr bgcolor ="# FFFFFF ">< td >-< td > Henry Parkes ( 2nd time )< td >< td > 22 March 1877 < td > 16 August 1877
< tr bgcolor ="# FFFFFF ">< td >-< td > Sir John Robertson ( 4th time )< td >< td > 17 August 1877 < td > 17 December 1877
< tr bgcolor ="# FFFFFF ">< td > 8 < td > James Farnell < td >< td > 18 December 1877 < td > 20 December 1878
< tr bgcolor ="# FFFFFF ">< td >-< td > Sir Henry Parkes ( 3rd time )< td >< td > 21 December 1878 < td > 4 January 1883
< tr bgcolor ="# FFFFFF ">< td > 9 < td > Alexander Stuart < td >< td > 5 January 1883 < td > 6 October 1885
< tr bgcolor ="# FFFFFF ">< td >-< td > John Robertson ( 5th time )< td >< td > 22 December 1885 < td > 22 February 1886
< tr bgcolor ="# FFFFDD ">< td > 1 < td > William Haines < td >< td > 30 November 1855 < td > 11 March 1857
< tr bgcolor ="# FFFFDD ">< td > 2 < td > John O ' Shanassy < td >< td > 11 March 1857 < td > 29 April 1857
< tr bgcolor ="# FFFFDD ">< td > – < td > William Haines < td >< td > 29 April 1857 < td > 10 March 1858

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It put an end to the War of the Castilian Succession, which ended with a victory of the Catholic Monarchs on land < ref name =" Bailey W. Diffie ">< sub >< big >↓</ big ></ sub > Bailey W. Diffie and George D. Winius “ In a war in which the Castilians were victorious on land and the Portuguese at sea, …” in Foundations of the Portuguese empire 1415-1580, volume I, University of Minnesota Press, 1985, p. 152 .</ ref > and a Portuguese victory on the sea .< ref name =" Historian Malyn Newitt ">< sub >< big >↓</ big ></ sub > Historian Malyn Newitt: “ All things considered, it is not surprising that the Portuguese emerged victorious from this first maritime colonial war.
The main events of this war were the indecisive < ref name =" British historian Ian Robertson ">< sub >< big >↓</ big ></ sub > British historian Ian Robertson: “ Civil war, however, was immediately provoked by the partisans of " la Beltraneja ", whose claim was supported by the king of Portugal, but after the indecisive battle of Toro ( 1476 ) the Portuguese withdrew leaving Fernando and Isabel firmly established ” in Spain, the mainland, E. Benn, 1980, p. 19 .</ ref >< ref name =" Historian Carl ">< sub >< big >↓</ big ></ sub > Historian Carl hanson:In march 1476, the Portuguese and Castilian armies met at Toro.
His Castilian partisans threw their support to Fernando and Isabella, rather than stick with a lost cause .” in Atlantic emporium: Portugal and the wider world, 1147-1497, volume 47 de Iberian studies, University press of the South, 2002, p. 128 .</ ref > battle of Toro ( 1 March 1476 ), transformed < ref name =" Historian Marvin ">< sub >< big >↓</ big ></ sub > Historian Marvin Lunenfeld: “.
(...) in 1479, (...) the two nations concluded terms for peace with the treaty of Alcáçovas, ending the struggle for the succession as well as their battle at sea .”< ref name = " Stephen R. Bown ">< sub >< big >↓</ big ></ sub > Stephen R. Bown-1494: How a family feud in Medieval Spain divided the world in half, D and M publishers inc., Canada, 2011, p. 76 .</ ref >
* Portugal gained a big war compensation of 106 676 dobles of gold < ref name =" Mendonça ">< sub >< big >↓</ big ></ sub > Mendonça, 2007, p. 102, 103 .</ ref > in the form of the marriage dowry of Afonso with Isabella.

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It made sense that for the Castilians Toro was considered as the divine retribution, the compensation desired by God to compensate the terrible disaster of Aljubarrota, still alive in the Castilian memory "< ref name =" Vicente Á. Palenzuela ">< sub >< big >↓</ big ></ sub > Vicente Á. Palenzuela-La guerra civil Castellana y el enfrentamiento con Portugal ( 1475-1479 )
Nevertheless, the war ended in defeat for the Castilian forces ,< ref name =" Historian Malyn Newitt ">< sub >< big >↓</ big ></ sub > Historian Malyn Newitt: “ However, in 1478 the Portuguese surprised thirty-five Castilian ships returning from Mina < nowiki > of Guinea </ nowiki > and seized them and all their gold.

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About a third of all reports of Bigfoot sightings are concentrated in the Pacific Northwest, with most of the remaining reports spread throughout the rest of North America .< ref name =" Car08_p118 ">< span id =" Car08 "></ span ></ ref > Some Bigfoot advocates, such as John Willison Green, have postulated that Bigfoot is a worldwide phenomenon.
The researchers estimate there are up to 2, 000 coyotes living in " the greater Chicago area " and that this circumstance may well apply to many other urban landscapes in North America .< ref name =" urb ">< span class =" plainlinks ">" Thriving under our noses, stealthily: coyotes " URL accessed on January 9, 2006 .</ span ></ ref > In Washington, D. C .' s Rock Creek Park, coyotes den and raise their young, scavenge roadkill, and hunt rodents.
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< td valign =" top ">< font size =" 2 "> 5144 </ font ></ td >

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