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The Game Boy Advance re-release as part of the Classic NES series holds a rating of 66 % on Metacritic based on 10 reviews.
Most reviews point out the game's addictiveness and praise the addition of wireless multiplayer, but some question the relevance of the game's re-release as a standalone title.
Eurogamer said the game was " still as playable, addictive and maddening as it was back in 1990 " but criticized Nintendo for re-releasing classic games as standalone titles in the Classic NES Series instead of as a compilation, like Atari's Atari Anthology or Midway's Midway Arcade Treasures.
Craig Harris, in his review for IGN, sarcastically expressed unease over the game's use of medicine.
He enjoyed the addictive gameplay, but criticized the black-and-white manual which made it difficult to understand the color-based gameplay mechanics.
While 1UP. com notes that the game's " color-matching action is more engrossing than Mario Bros .' turtle-punching platform hopping ", the reviewer strongly questions whether this re-release is worth its sale price by itself when a version of Dr. Mario was included in another Game Boy Advance game, WarioWare, Inc .: Mega Microgames !.

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