Page "G protein-coupled receptor" Paragraph 25

Similar to GPCRs, the adiponectin receptors 1 and 2 ( ADIPOR1 and ADIPOR2 ) also possess 7 transmembrane domains.

However ADIPOR1 and ADIPOR2 are orientated oppositely to GPCRs in the membrane ( i. e., cytoplasmic N-terminus, extracellular C-terminus ) and do not associate with G proteins.