Page "Haematopoiesis" Paragraph 28

For a decade now, the evidence is growing that HSC maturation follows a myeloid-based model instead of the ' classical ' schoolbook dichotomy model.

In the latter model, the HSC first generates a common myeloid-erythroid progenitor ( CMEP ) and a common lymphoid progenitor ( CLP ).

The CLP produces only T or B cells.

The myeloid-based model postulates that HSCs first diverge into the CMEP and a common myelo-lymphoid progenitor ( CMLP ), which generates T and B cell progenitors through a bipotential myeloid-T progenitor and a myeloid-B progenitor stage.

The main difference is that in this new model, all erythroid, T and B lineage branches retain the potential to generate myeloid cells ( even after the segregation of T and B cell lineages ).

The model proposes the idea of erythroid, T and B cells as specialized types of a prototypic myeloid HSC.

Read more in Kawamoto et al.

2010.