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In Arthur C. Clarke's short story " Technical Error " there is an example of differing chirality.
This is not a case of alien life, rather it is an accident.
The concept of reversed chirality also figured prominently in the plot of James Blish's Star Trek novel Spock Must Die !, where a transporter experiment gone awry ends up creating a duplicate Spock who turns out to be a perfect mirror-image of the original all the way down to the atomic level.
An example of silicon based life forms takes place in the Alan Dean Foster novel Sentenced to Prism in which the protagonist Evan Orgell is trapped on a planet whose entire ecosystem is mostly silicon-based.

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