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Some evidence suggests that Earth's original atmosphere might have contained fewer of the reducing molecules than was thought at the time of the Miller – Urey experiment.

There is abundant evidence of major volcanic eruptions 4 billion years ago, which would have released carbon dioxide, nitrogen, hydrogen sulfide ( H < sub > 2 </ sub > S ), and sulfur dioxide ( SO < sub > 2 </ sub >) into the atmosphere.

Experiments using these gases in addition to the ones in the original Miller – Urey experiment have produced more diverse molecules.

The experiment created a mixture that was racemic ( containing both L and D enantiomers ) and experiments since have shown that " in the lab the two versions are equally likely to appear.

" However, in nature, L amino acids dominate ; later experiments have confirmed disproportionate amounts of L or D oriented enantiomers are possible.