Page "Polly Matzinger" Paragraph 11

In a recent article in Nature Immunology, Matzinger makes a case for what she now views as the most important implication of the Danger Model: that the tissues of the body are a large part of what drive immune response.

She argues that immunologists have had overly simplistic and schematic ideas about immune response because of the limits of their assays, and that organs are likely to induce immune responses that are best-suited to defending the organ from the damage of microbes but also from the damage of the immune system itself.

She also asserts that the relationship of the immune system to commensal bacteria remains poorly understood but is likely to be important.