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** platelet-activating factor
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platelet-activating and factor
GPCRs include receptors for sensory signal mediators ( e. g., light and olfactory stimulatory molecules ); adenosine, bombesin, bradykinin, endothelin, γ-aminobutyric acid ( GABA ), hepatocyte growth factor ( HGF ), melanocortins, neuropeptide Y, opioid peptides, opsins, somatostatin, GH, tachykinins, members of the vasoactive intestinal peptide family, and vasopressin ; biogenic amines ( e. g., dopamine, epinephrine, norepinephrine, histamine, glutamate ( metabotropic effect ), glucagon, acetylcholine ( muscarinic effect ), and serotonin ); chemokines ; lipid mediators of inflammation ( e. g., prostaglandins, prostanoids, platelet-activating factor, and leukotrienes ); and peptide hormones ( e. g., calcitonin, C5a anaphylatoxin, follicle-stimulating hormone ( FSH ), gonadotropin-releasing hormone ( GnRH ), neurokinin, thyrotropin-releasing hormone ( TRH ), cannabinoids, and oxytocin ).
The granules include ADP, serotonin, platelet-activating factor ( PAF ), vWF, platelet factor 4, and thromboxane A < sub > 2 </ sub > ( TXA < sub > 2 </ sub >), which, in turn, activate additional platelets.
Granule contents of basophils are abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor, and other substances.
Interestingly, cPLA < sub > 2 </ sub > may also release the lysophospholipid that becomes platelet-activating factor.
Pafase is the recombinant form of platelet-activating factor acetylhydrolase ( PAF-AH, also known as lipoprotein-associated phospholipase A2 ), an enzyme made naturally by macrophages and found in human blood.
PAF-AH inactivates platelet-activating factor, a phospholipid that plays a role in the inflammation seen in sepsis.
Hyperalgesia is induced by platelet-activating factor ( PAF ) which comes about in an inflammatory or an allergic response.
In 1979 he published a well-known paper on the structure of platelet-activating factor and its relationship with histamine.
Ether lipids can also act directly in cell signaling, as the platelet-activating factor is an ether lipid signaling molecule that is involved in leukocyte function in the mammalian immune system.
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