Amathus still flourished and produced a distinguished patriarch of Alexandria, St. John the Merciful, as late as 606-616, and a ruined Byzantine church marks the site ; but it declined and was already almost deserted when Richard Plantagenet won Cyprus by a victory there over Isaac Comnenus in 1191.

* 1185 – Isaac II Angelus kills Stephanus Hagiochristophorites and then appeals to the people, resulting in the revolt that deposes Andronicus I Comnenus and places Isaac on the throne of the Byzantine Empire.

* Isaac I Comnenus, Byzantine emperor ( d. 1062 )

* Isaac I Comnenus resigns as Byzantine Emperor, appointing Constantine Ducas as his successor.

In 1185, the last Byzantine governor of Cyprus, Isaac Comnenus of Cyprus from a minor line of the Imperial house, rose in rebellion and attempted to seize the throne.

The last Byzantine governor of the Island was Isaac Comnenus who declared himself emperor of the island and ruled the island from 1183 – 1191.

Joan refused to come ashore, fearing she would be captured and held hostage by Isaac Comnenus, who hated all Franks.

Richard finally met and defeated Isaac Comnenus at Tremetousia.

Isaac Comnenus, the Byzantine governor of Cyprus, was heartless and cruel, and loathed the Latins.

When Richard arrived in Limassol and met Isaac Comnenus, he asked him to contribute to the crusade for the liberation of the Holy Land.

En route to the Holy Land, the ship carrying Berengaria and Joan went aground off the coast of Cyprus, and they were threatened by the island's ruler, Isaac Comnenus.

He then sent a fleet of 70 ships, but it failed in its attempt to recover Cyprus from the rebellious noble Isaac Comnenus, thanks to Norman interference.

Isaac I Komnenos ( or Comnenus ) (, Isaakios I Komnēnos ) ( c. 1007 – 1061 ) was Byzantine Emperor from 1057 to 1059, and the first reigning member of the Komnenos dynasty.

He participated in the campaign against Isaac Comnenus of Cyprus.

Meanwhile, Guy was compensated for the loss of his kingdom by purchasing Cyprus from the Templars in 1192, who had themselves purchased it from Richard, who had wrested it from Isaac Comnenus en route to Palestine.

There the despot Byzantine king of the island, Isaac Comnenus, is said to have fled after Richard the Lion Heart conquered Cyprus in 1191.

The island was conquered in 1191 by King Richard I of England during the Third Crusade, from Isaac Comnenus, an upstart local governor and self-proclaimed emperor claiming the Byzantine Empire.

* unnamed daughter, the wife of Isaac Ducas Comnenus

At the end of 1182, the Byzantine governor of Cilicia, Isaac Comnenus, in revolt against the Emperor Andronicus I Comnenus, sought help from Bohemond III against Roupen and admitted his troops into Tarsus.

Isaac Comnenus was ransomed by the Knights Templar.

Isaac Komnenos or Comnenus (, Isaakios Komnēnos ; c. 1155 – 1195 / 1196 ), was the ruler of Cyprus from 1184 to 1191, before Richard I's conquest during the Third Crusade.

Alexios was the son of Ioannis Komnenos and Anna Dalassena, and the nephew of Isaac I Komnenos ( emperor 1057 – 1059 ).

When Isaac was 40, Abraham sent Eliezer, his steward, into Mesopotamia to find a wife for Isaac, from his nephew Bethuel's family.

Among the founders of the Tosafist school were Rabbi Jacob b. Meir ( known as Rabbeinu Tam ), who was a grandson of Rashi, and, Rabbenu Tam's nephew, Rabbi Isaac ben Samuel.

He had many pupils from different countries, among whom should be mentioned Eleazar ben Isaac ( ha-Gadol =" the Great "), nephew of Simeon ha-Gadol ; and Jacob ben Yakar, teacher of Rashi.

After his death in 1866, his nephew, William Archer Redmond, this John Redmond's father, was elected to the seat and soon emerged as a prominent supporter of Isaac Butt's new policy for home rule.

" His nephew William Archer Redmond ( 1825-1880 ) sat as an MP in Isaac Butt's Home Rule Party from 1872 until 1880.

* Hillel Kook ( 1915-2001 ), nephew of Abraham Isaac Kook, prominent Revisionist Zionism activist during World War II

Twenty years later, Laban's nephew Jacob was born to Isaac and Rebekah.

* In 1753 – 4, several issues by " William Bickerstaffe, nephew of the late Isaac Bickerstaffe " were published.

* Aaron Van Schaick Cochrane ( 1858 – 1943 ), U. S. Representative from New York, nephew of Isaac Whitbeck Van Schaick

He was the nephew of William Muhlenberg Hiester and the cousin of Isaac Ellmaker Hiester.

He was the father of Isaac Hiester, uncle of Hiester Clymer, and nephew of John Hiester and Daniel Hiester.

The spar torpedo was invented during the American Civil War by E. C. Singer, a private engineer who worked on secret projects for the benefit of the Confederate States of America ( Singer was the nephew of Isaac Singer, inventor of the sewing machine ).

The dynasty returned to the throne with the accession of Alexios I Komnenos, Isaac I's nephew, in 1081.

At this time, too, Theodora interceded with Andronikos to pay the ransom for her nephew, Isaac, a former Byzantine governor of Isauria now a captive in Armenia ; Andronikos afterwards regretted doing so, since Isaac rebelled and seized control of Cyprus.

Ezekial Budgen was involved in a quarrel with his brother Isaac, which led to William Budgen ( Ezekial's nephew ) being granted a piece of land in near the mill in 1796 with liberty to erect a windmill upon it.

He was the nephew of the painter Aert Mijtens, the older brother of the painter Isaac Mijtens, and the father of the painter Daniel Mijtens the Younger.

**** Edward Bernays ( 1891-1995 ), nephew of Sigmund Freud, great-grandson of Isaac Bernays and the " father of public relations "

** Lewis Adolphus Bernays ( 1831-1908 ), a public servant and agricultural writer in Australia ( son of Adolphus and a nephew of Isaac Bernays )

When a fundraising campaign to refurbish and re-house the collection began, Dr. Wistar ’ s great nephew Colonel Isaac Jones Wistar became involved.

* David Wolfson, Baron Wolfson of Sunningdale ( born 1935 ), British politician and businessman, nephew of Isaac Wolfson, former chairman of GUS and Next