Between the junction of I-55 and I-57 in Sikeston, Missouri and the junction of I-55 and I-90 / 94 in Chicago, I-55 travels for, while the combination of I-57 and I-94 is only long between the same two points.

Likewise, at its southern end, Chicago is the control city listed for I-57 on signs on northbound I-55 south of Sikeston, Missouri, even though I-55 also goes to Chicago.

The Morehouse Elementary School is part of the Sikeston school system.

As of the 2000 U. S. Census, the city had a population of 16, 651 ; a 2008 estimate showed the population to be 17, 096, an increase of 2. 67 %, and is the third largest city in Missouri's 8th Congressional District after Cape Girardeau and Sikeston.

Although popular family restaurant Lambert's Cafe is generally referred to as being located in Sikeston, the restaurant is actually located just inside the Miner city limits.

Lambert's originated in Sikeston, but moved closer to I-55, which is located on the eastern side of Miner.

Sikeston () is a city located both in southern Scott County and northern New Madrid County, in the U. S. state of Missouri.

It is geographically situated just north of the " Missouri Bootheel ", although many locals consider Sikeston a part of it.

By way of Interstate 55, Interstate 57, and U. S. Route 60, Sikeston is close to the halfway point between St. Louis, Missouri and Memphis, Tennessee and 4 hours away from Nashville, Tennessee.

It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41, 143.

Sikeston is located at ( 36. 879570 ,-89. 585172 ).

The city is situated upon the Sikeston Ridge which runs north and south from north of Sikeston through New Madrid.

Today Kingshighway, also known as Business U. S. Highway 61 serves Sikeston as a primary north-south street and is lined with businesses and older historic homes.

* Sikeston is also home to the Missouri National Guard unit Company C 1140th Engineer Battalion which took part in Operation Iraqi Freedom from February 2004 until February 2005.

* The first house in Sikeston is believed to have been located at 318 Baker Lane.

* The Sikeston Factory Outlet Mall is a 22-store outlet shopping center and is the only outlet center between St. Louis and Memphis that serves the five-state region.

Sikeston Factory Outlet Stores is located at Exit 67 off I-55, only one mile north of the I-55 / I-57 interchange.

* The Sikeston Depot, a train depot built in 1916 and on the National Register of Historical Places, is now used as a cultural center and museum.

The Sikeston Little Theater is the oldest performing arts group between St. Louis and Memphis.

Sikeston is home to several houses of worship.

Sikeston High School's mascot is the Bulldog and the school colors are red and black.

The Scott County Central School District is also located five miles ( 8 km ) north of Sikeston on U. S. Route 61.

* Blodgett ’ s Paintball Planet — a recreational area located north of Sikeston

* Three Rivers Community College Center located at 103 Kathleen Street, Sikeston.

In 1988, the restaurant moved again to a site conveniently located for travelers along Interstate 55 in Sikeston.

It goes from Sikeston, Missouri, at Interstate 55 to Chicago, Illinois, at Interstate 94.

Although Sikeston was only a small village during the Civil War, its position at the railroad and highway intersection gave it some importance.

On November 3, 1861, from Cairo, Illinois, Brigadier General Ulysses S. Grant wrote a letter to Colonel Richard J. Oglesby, commander of the Union Headquarters District Southeast Missouri at Bird ’ s Point, ordering his troops to " strike for Sikeston " from the Mississippi River town of Commerce.

Brigadier General Benjamin Prentiss and Colonel W. H. L. Wallace were also converged in the Sikeston area in preparation of Grant's attack at the Battle of Belmont.

* On January 21, 1955, a mostly unknown 20-year-old Elvis Presley performed at the Sikeston Armory.

* The 1962 film The Intruder, starring William Shatner and directed by Roger Corman, features scenes shot on location in downtown Sikeston and at the old courthouse in Charleston.

* The Sikeston Jaycee Bootheel Rodeo-Held around the first of August for over 50 years, the Sikeston Jaycee Bootheel Rodeo provides top qualify family entertainment at an affordable price.

* Matthew S. Murray, who was appointed Director of Public Works for Kansas City at the request of Tom Pendergast in 1926, lived in Sikeston from 1908 until 1922.

* Brandon Barnes, a former Washington Redskins NFL player, former all-conference linebacker at the University of Missouri, and former all-state defensive back for the 1998 conference champion Sikeston High School football team.

* Historic maps of Sikeston in the Sanborn Maps of Missouri Collection at the University of Missouri

He taught and coached in Sikeston, Missouri, Cairo and El Dorado Springs ; then starting in 1942, at Freeport High School, Freeport, Illinois, where he was head football coach from 1951 – 1954.

** Order 2011-4-12: re-selecting Hyannis Air Service, Inc. d / b / a Cape Air, to provide essential air service ( EAS ) at Marion / Herrin, Illinois ( Marion ) and Quincy, Illinois / Hannibal, Missouri ( Quincy ), and Cape Girardeau / Sikeston, Missouri ( Cape Girardeau ), for the four-year period from December 1, 2011, through November 30, 2015, for a combined annual subsidy rate of $ 5, 689, 438 ($ 2, 104, 616 for Marion, $ 1, 956, 856 for Quincy, and $ 1, 627, 966 for Cape Girardeau ).

Its eastern terminus is at the Mississippi River in Belmont ; its western terminus is at U. S. Route 61 / U. S. Route 62 midway between Sikeston and New Madrid.

Its northern terminus is at U. S. Route 60 midway between Sikeston and Dexter.

Its eastern terminus is at Business U. S. Route 60 west of Sikeston ; its western terminus is at Route 25 in Dexter.

In the state of Missouri, Interstate 57 runs northbound from Sikeston to the Cairo I-57 Bridge over the Mississippi River south of Cairo, Illinois.

US 60 intersects Interstate 55 and Interstate 57 just southeast of Sikeston, and runs concurrently with I-57 from this junction to the east side of Charleston.