One downside, however, is that complexes may not separate cleanly or predictably, since they cannot move through the polyacrylamide gel as quickly as individual, denatured proteins.

The downside, however, is that quantum dots are usually made of quite toxic elements.

There is a downside to such imports, however ; the massive importation of used clothing from the developed world has resulted in a near-total collapse of the Zambian indigenous textile industry.

A downside compared to similar contemporary designs ( such as the Z80 ) was the fact that the buses required demultiplexing ; however, address latches in the Intel 8155, 8355, and 8755 memory chips allowed a direct interface, so an 8085 along with these chips was almost a complete system.

A downside is, however, that in order to include more detail, multiple samples might need to be played back at once ( a trumpet might include a breath noise, a growl, and a looping soundwave used for continuous play ).

The most significant downside, however, is the cumbersome usability in rough terrain or on the edges of lawns, as the lifting air-cushion is destroyed by wide gaps between the chassis and the ground.

A downside to the cadmium selenide dots, however, is that they are highly toxic to the body.

The downside to this, however, is that the playing time for the CD layer of some early DualDiscs decreased from the standard 74 minutes of a conventional CD to around 60 minutes, although this early limitation was later overcome.

P. S 44. has small class sizes, however the downside of P. S.

His extra size and power did have a downside, however ; he needed to absorb more energy more frequently in order to stay alive.

The downside to this, however, is that much ground pollution remains from the track ’ s previous use.

Its downside however is that it only seats two.

The downside is however, variable rate fares need heavy investment in ticketing technologies and are far more complicated to implement for the transit operator and to decipher the fare for the transit rider.

The downside to this design, however, is its high operating pressure, which leads to a larger recoil and less accuracy.

The United States Postal Service, after at first seeming supportive of the program, later resisted its personnel being included in this program, reasoning that if mail carriers became perceived as law enforcement personnel that they would be placed in danger at a level for which they could not reasonably be expected to be prepared, and that the downside of the program hence vastly outweighed any good that it could accomplish.

The downside to message boards was that people would have to wait until another user replied to their posting, which, with people all around the world in different time frames, could take awhile.

The downside to this is that, when re-released, the species may lack the genetic adaptations and mutations which would allow it to thrive in its ever-changing natural habitat.

On the downside, an engine of this size had never been built before and development would be expensive and risky.

One downside of this approach is that exchange rate appreciation would reduce the competitiveness of the export sector.

The most obvious downside to having gull-wing doors is that, should the car roll over and come to rest on its roof, exit by the doors would be impossible, requiring a large wind screen opening to escape.

He would become a role model & spoke ’ s person to travel to schools to speak to the youth about the downside of drugs, but somehow Donald would wind up on the FBI hit list along with rappers NWA, Public Enemy, Ice-T & 2 Live Crew for his songs Car Chase & Who Got The Gun.

The downside is that this doubles the storage, and both devices ( copies ) need to be updated simultaneously with some overhead and possibly some delays.

The downside is that this doubles the storage, and both devices ( copies ) need to be updated simultaneously with some overhead and possibly some delays.

The downside to this approach is that the new functionality is no longer a part of string ; instead, it is isolated in its own set of functions that have to be called separately.

In order to bypass this downside, a number of languages have type loopholes, usually unchecked casts that may be used by the programmer to explicitly allow a normally disallowed operation between different types.

) However, the downside was that operating systems had to have an awareness of this new set of instructions in order to be able to save their register states.

This gives programmers an environment similar to a desktop operating system like Linux or Microsoft Windows, and is therefore very productive for development ; on the downside, it requires considerably more hardware resources, is often more expensive, and because of the complexity of these kernels can be less predictable and reliable.

However, one downside is that an arch pushes outward at the base, and this needs to be restrained in some way, either with heavy sides and friction or angled cuts into bedrock or similar.

However, the downside is that promotional costs will also be much higher due to having to employ a separate staff.

Various bots add and attempt to correct interlanguage links: if A links to B, B will be linked to A, and if A links to B and B to C, A will be linked to C. The downside is that an error in an interlanguage link in one Wikipedia propagates to other Wikipedias.

The downside of that is also that it continues to resonate, and threatens to eclipse all else in one's long career if one does not up the ante and stay at it, in a way that may not ordinarily be necessary.

On the downside, Laserfire no longer has the optical system of the original, which served an important second duty by allowing the aircraft to be visually identified at long range.

On his decision to leave Melbourne Barassi stated “ Inevitably with many decisions in life there will be a downside.

A downside of color-change garments is that the dyes can easily be damaged, especially by washing in warm water, or dye other clothes during washing.

While this power is useful for designing reductions, the downside is that certain classes such as NP are not known to be closed under Cook reductions ( and are widely believed not to be ), so they are not useful for proving that a problem is in NP.

The only downside was performance ; the bubbles had to cycle to the far end of the sheet before they could be read.

The downside is that the various weather streams ( radar, cloud coverage, lightning, forecast, TAF, FA, etc ...) takes around 15 minutes to complete the data download, meaning that the information can somewhat be out-of-date by the time it is shown.

The major downside of using softsynths can often be more latency ( delay between playing the note and hearing the corresponding sound ).

Halibut tend to be a mottled brown on their upward-facing side and white on their downside

The downside of this is that mailing lists and other legitimate mass-mailings will have to be explicitly whitelisted or they will suffer too.

The downside to this approach was that the mask cut off the vast majority of the beam energy, allowing it to hit the screen only 15 % of the time, requiring a massive increase in beam power to produce acceptable image brightness.