Although major concerns about benzodiazepine tolerance and withdrawal have been raised, there is no evidence for significant dose escalation in patients using benzodiazepines long-term.

Geographical isolation and a poorly developed infrastructure are major impediments to long-term growth.

Hawk's contract with Fox ended in May 1929, and he never again signed a long-term contract with a major studio but managed to remain an independent producer-director for the rest of his long career.

Broader economic improvement, long-term fiscal health, and sustained increases in the standard of living still depend on the government passing major policy reforms and on continued development of Iraq's massive oil reserves.

His major innovations were to blend these traditional elements in a new way, to systematize the approach to battle, and to standardize organization, methods and weapons, particularly in his adoption of the ilkwa-the Zulu thrusting spear, unique long-term regimental units, and the " buffalo horns " formation.

In The Prophecies he compiled his collection of major, long-term predictions.

Despite the wide regional variations in climate by latitude and other geographic factors, the long-term average global climate is quite stable during interglacial periods, and variations of a degree or two of average global temperature have historically had major effects on the ecological balance, and on the actual geography of the Earth.

A major problem is gaining long-term adherence to therapy from people with osteoporosis with half not taking their medications and most discontinuing within one year.

The prosperity associated with the major boom raised expectations for long-term growth.

Hannibal defeated the Roman legions in several major engagements, including the Battle of the Trebia, the Battle of Lake Trasimene and most famously at the Battle of Cannae, but his long-term strategy failed.

Strong evidence suggests that neither site nor route of antibiotic administration affects the short or long-term major outcome of women with mild or moderate disease.

A major long-term motivation for the global seismographic monitoring has been for the detection and study of nuclear testing.

A major nuclear exchange could have severe long-term effects, primarily from radiation release, but also from the production of high levels of atmospheric pollution leading to a " nuclear winter " that could last for decades, centuries, or even millennia after the initial attack.

A long-term effect of the Great Depression was the departure of every major currency from the gold standard, although the initial impetus for this was World War II.

The system provides places for long-term science and management studies in major vegetation types of the of public land administered by the Forest Service.

Hyperthyroidism plays a major role in psychiatric morbidity in Graves ' disease, and is associated with long-term mood disturbances.

By the above hypothesis, the graph indicates one of the major criticisms of deficit spending as a way to stimulate the economy: rising interest rates lead to crowding out – i. e., discouragement – of private fixed investment, which in turn may hurt long-term growth of the supply side ( potential output ).

Historians and economists consider the GI Bill a major political success — especially in contrast to the treatments of World War I veterans — and a major contribution to America's stock of human capital that sped long-term economic growth.

The Congressional Budget Office ( CBO ) has written that " future growth in spending per beneficiary for Medicare and Medicaid — the federal government ’ s major health care programs — will be the most important determinant of long-term trends in federal spending.

The later years of Michael's reign were marked by two major military disasters with long-term effects, the beginning of the Muslim conquest of Sicily, and the fall of Crete to the Saracens.

Major improvements to the public school system and downtown district are currently among the most visible aspects ; long-term effects include major highway improvements on U. S. Route 61 and a much-discussed potential expansion of Tunica Municipal Airport.

A youth may apply for the award after completing four major, specified, long-term projects called Reflections, and three self-selected projects, called Advocacies, dealing an area of concern of the youth member's choosing ; one of which must be to Camp Fire, and one cannot be to Camp Fire.

A 1995 study by the federal banking regulators of commercial bank trading activity from June 30, 1984, to June 30, 1994, concluded that “ trading activities are an increasingly important source of revenue for banks ” and that “ otwithstanding the numerous press reports that focus on negative events, the major commercial banks have experienced long-term success in serving customers and generating revenues with these activities .” In reporting the study results, the American Banker described “ proprietary trading ” as “ basically securities trading not connected to customer-related bank activities “ and summarized the study as finding that “ proprietary trading has been getting a bad rap .”

Deane and J. R. Thomson write this valid conclusion, “ The Book of Obadiah is occupied with one subject – the punishment of Edom for its cruel and unbrotherly love conduct towards Judah ...” One can link this idea of punishment to one of the major prophets “ Ezekiel ” who “... interprets the exile to Babylon and the destruction of Jerusalem as deserved punishments for the sins of those who themselves committed them .” Verses 3-7 in Obadiah explain to the reader the reason for the punishment theme, “ Confidence in one ’ s power, intelligence, allies, or the topographical features of one ’ s territory is often mentioned as an attribute of those who foolishly confront the Lord and are consequently punished .” Although destruction is vital to understanding Obadiah, it is of note to understand the destruction being a consequence of action.

Murray reports that the only event of major consequence during Kenzō's reign had to do with the filial respect he showed for his murdered father.

As such, increase in the price of kerosene can have a major political and environmental consequence.

As a consequence Paramount fell from No. 1 in the international markets to the lowest ranked major studio in 2006 but recovered in 2007 if the DreamWorks films, acquired by Paramount but still distributed internationally by Universal, are included in Paramount's market share.

The punishment of Prometheus as a consequence of the theft is a major theme of his mythology, and is a popular subject of both ancient and modern art.

Pentecostals cite four major reasons for believing in divine healing: 1 ) it is reported in the Bible, 2 ) Jesus ' healing ministry is included in his atonement ( thus divine healing is part of salvation ), 3 ) " the whole gospel is for the whole person "— spirit, soul, and body, 4 ) sickness is a consequence of the Fall of Man and salvation is ultimately the restoration of the fallen world.

The current extent of Hudson Bay, the Great Lakes and other major lakes of North America are a consequence of the Canadian Shield's readjustment since the last ice age ; different shorelines have existed over the course of Quaternary time.

A major consequence of the Thirty Years ' War was the devastation of entire regions, denuded by the foraging armies ( bellum se ipsum alet ).

Moreover, Themistocles's doctrine of Athenian naval power, and the establishment of Athens as a major power in the Greek world were of enormous consequence during the 5th century BC.

In consequence, Army forces deploying to Africa suffered serious initial reverses when encountering German armored combat units in Africa at Kasserine Pass and other major battles.

The major consequence of Cornwallis's surrender was the beginning of negotiations that eventually resulted in peace and British recognition of the independent United States of America.

As a consequence of this one major academic study found that " the contemporary males of Malta most likely originated from Southern Italy, including Sicily and up to Calabria ".

Fish and chips became a stock meal among the working classes in Great Britain as a consequence of the rapid development of trawl fishing in the North Sea, and the development of railways which connected the ports to major industrial cities during the second half of the 19th century, which meant that fresh fish could be rapidly transported to the heavily populated areas.

As a consequence of Saud's scheme, he was forced by senior members of the Saudi royal family to informally cede most of his powers to his brother, King Faisal, an advocate of pan-Islamic unity rather than Arab nationalism and a major opponent of Nasser.

As a consequence of the above, most Canadian medical students who wish to pursue an academic emergency medicine career, and / or work primarily in a major academic center, choose the FRCP route of certification.

As a consequence, the Kent County government is a major employer in the area as well.

Under new leadership, Bulgaria surrendered to the Allies and as a consequence, lost not only the additional territory it had fought for in the major conflict, but also the territory it had won after the Balkan Wars giving access to the Aegean Sea.

One other major consequence of the Betamax technology's introduction to the U. S. was the lawsuit Sony Corp. v. Universal City Studios ( 1984, the " Betamax case "), with the U. S. Supreme Court determining home videotaping to be legal in the United States, wherein home videotape cassette recorders were a legal technology since they had substantial noninfringing uses.

# The Genesis According to Spiritism — Tries to reconcile religion and science, dealing with the three major points of friction between the two: the origin of the universe ( and of life, as a consequence ) and the concepts of miracle and premonition.

As a consequence he withdrew diplomatic support for the UDI regime which had become a major obstacle for Vorster's new policy.

The creation of Sea King ASaC7, and earlier AEW. 2 and AEW. 5 is the consequence of lessons learnt by the Royal Navy in the 1982 Falklands War when the lack of AEW coverage for the task force was a major tactical shortcoming.

As a consequence, major damage has occurred to local economies and environments.

The stringent crowd control measures now in force at major holiday events are a direct consequence of the inquest's recommendations.

As a consequence of the frequent service on this line, Bracknell is now a major commuter centre with its residents travelling in both directions ( westwards to Reading and eastwards to London ( Waterloo )).