In that year the outbreak of several revolutions around Europe and a crisis in Poland appeared to presage another major European war.

The disease was named after the Brazilian physician and infectologist Carlos Chagas, who first described it in 1909, but the disease was not seen as a major public health problem in humans until the 1960s ( the outbreak of Chagas disease in Brazil in the 1920s went widely ignored ).

The last major outbreak of cholera in the United States occurred in 1910 – 1911.

* 2008 – A major tornado outbreak across the Southern United States leaves 57 dead, the most since the May 31, 1985 outbreak that killed 88.

For much of the book he is in Italy, dealing with a major crisis which for a time seemed to threaten the outbreak of a new European war ( as he tells Bunter ).

The Great Plague of 1665 was the last major outbreak of the plague in England.

The outbreak of Spanish influenza in Spain and elsewhere, along with a major economic slowdown in the postwar period, hit Spain particularly hard, and the country went into debt.

A major economic transformation and national industrial development plan led by Minister Eugeniusz Kwiatkowski, the main architect of the Gdynia seaport project, was in progress at the time of the outbreak of the war.

On his return in 1545, he assisted the prominent physician Louis Serre in his fight against a major plague outbreak in Marseille, and then tackled further outbreaks of disease on his own in Salon-de-Provence and in the regional capital, Aix-en-Provence.

" Indeed, the nearly fifty years of Greek history that preceded the outbreak of the Peloponnesian War had been marked by the development of Athens as a major power in the Mediterranean world.

The Great Plague of London of 1665 – 66 was the last major outbreak of the plague in England.

The last major outbreak of the disease in humans occurred between 1974 and 1976, where an estimated 10, 000 to 20, 000 cases were recorded.

Rashi and his family survived the major anti-semitic outbreak when he was 45 years old ; many of his teachers who were some of Judaism's greatest Ashkenazi sages and his mentors did not survive.

The last major U. S. outbreak was in 1905 in New Orleans.

Two major pandemics occurred in the 20th century: an outbreak of a severe strain of influenza ( the Spanish Flu ) which killed some 25 million or more people in 1918-1919, and the appearance of AIDS in the 1980s on.

* Cuba suffers a major outbreak of Dengue fever, with 344, 203 cases.

This last major outbreak of Bubonic plague in the British Isles was possibly introduced by Dutch prisoners of war.

* May 4 – May 10 – A major severe weather outbreak spawns more tornadoes than any week in U. S. history ; 393 tornadoes are reported in 19 states.

* The fourth major outbreak of the sweating sickness occurs in England.

* In Henan province, China, a severe drought with swarms of locusts is made worse by a major epidemic outbreak of the plague.

Upon the outbreak of World War II, Patton's expertise in mechanized warfare was recognized by the Army, and he was quickly made a brigadier general and, less than a year later, a major general.

In her " capitalism peace theory ," Ayn Rand held that the major wars of history were started by the more controlled economies of the time against the freer ones and that capitalism gave mankind the longest period of peace in history — a period during which there were no wars involving the entire civilized world — from the end of the Napoleonic wars in 1815 to the outbreak of World War I in 1914, with the exceptions of the Franco-Prussian War ( 1870 ), the Spanish-American War ( 1898 ), and the American Civil War ( 1860-1863 ), which, notably, occurred in perhaps the most liberal economy in the world at the peak of the industrial revolution.

Since the 15th century the city acted as a major Polish and later also as a Jewish cultural center ; with Poles and Jews comprising a demographic majority of the city until the outbreak of World War II, the Holocaust, and the population transfers of Poles that followed.

In developed countries, due to nearly universal advanced water treatment and sanitation practices, cholera is no longer a major health threat.

One of the major contributions to fighting cholera was made by the physician and pioneer medical scientist John Snow ( 1813 – 1858 ), who in 1854 found a link between cholera and contaminated drinking water.

This eliminated the threat of cholera epidemics from the major developed cities in the world.

About 8, 600 died in the largest German epidemic of the late 19th century, and the last major cholera epidemic in a major city of the Western world.

Lexington Cemetery is on the National Register of Historic Places, not only because of notable people interred there, but because it was founded during the major cholera epidemic of 1848.

In civilian ambulances, a major advance was made ( which in future years would come to shape policy on hospitals and ambulances ) with the introduction of a transport carriage for cholera patients in London during 1832.

Outbreaks of smallpox ( 1817, 1848 ) and cholera ( 1849 ) took a major toll on the Comanche, whose population dropped from an estimated 20, 000 in mid-century to just a few thousand by the 1870s.

Due to a major fire, a cholera epidemic, and two continuances, the new trial did not begin until January 1850.

In the 19th century major treatment works were built in London in response to cholera threats.

It is often the dominant species in major mortality events from avian botulism and avian cholera, and can also contract avian influenza, the H5N1 strain of which is highly pathogenic and occasionally infects humans.

The introduction of medical bacteriology in the 1870s and 1880s provided a challenge to the miasma theory, though consensus was not reached immediately ; concerns over sewer gas, which was a major component of the miasma theory developed by Galen and brought to prominence by the Great Stink, led to continuing proponents of the theory, who observed that sewers enclosed the refuse of the human bowel, which medical science had discovered could teem with typhoid, cholera, and other microbes.

There was a major outbreak of cholera in London in 1849 which killed around 15, 000 people.

As chief engineer of London's Metropolitan Board of Works his major achievement was the creation ( in response to the " Great Stink " of 1858 ) of a sewer network for central London which was instrumental in relieving the city from cholera epidemics, while beginning the cleansing of the River Thames.

Taylor died in 1833 in Franklin County, Kentucky near Forks of Elkhorn Creek, the year of a major cholera epidemic in the region.

The city's expansion resulted in regular outbreaks of water-borne diseases and major epidemics such as typhoid, cholera and dysentry because of the lack of clean water.

He later covered the Siege of Sevastopol where he coined the phrase " thin red line " in referring to British troops, writing that " Russians dash on towards that thin red streak topped with a line of steel ..." Following Russell's reports of the appalling conditions suffered by the Allied troops conducting the siege, including an outbreak of cholera, Samuel Morton Peto and his partners built the Grand Crimean Central Railway, which was a major factor leading to the success of the siege.

London water supply infrastructure developed over many centuries from early mediaeval conduits, through major 19th century treatment works built in response to cholera threats, to modern large scale reservoirs.

Conditions worsened with cholera outbreaks ( 1889 – 92 ), a typhus epidemic, and a major smallpox epidemic ( 1889 – 90 ).

In 2004, the relatively developed town of Kribi suffered a major cholera epidemic.

Peasants without stable income were forced to live off meager food supplies, disease was spreading rapidly, plagues were reported, including a major cholera epidemic which killed at least 55, 000 people.

The Northern Outfall Sewer ( NOS ) is a major gravity sewer which runs from Wick Lane in Hackney to Beckton Sewage Works in east London ( east of Stratford ); most of it was designed by Joseph Bazalgette after an outbreak of cholera in 1853 and " The Big Stink " of 1858.