Alprostadil in combination with the permeation enhancer DDAIP has been approved in Canada under the brand name Vitaros as a topical cream first line treatment for erectile dysfunction.

He had used topical materials throughout his series, but in 1959, his Starship Troopers was considered by the Scribner's editorial staff to be too controversial for their prestige line, and they rejected it ; Heinlein found another publisher, feeling himself released from the constraints of writing novels for children, and he began to write " my own stuff, my own way ", and he wrote a series of challenging books that redrew the boundaries of science fiction, including his best-known work, Stranger in a Strange Land ( 1961 ), and The Moon Is a Harsh Mistress ( 1966 ).

Therefore, Jack Carson's final line was not only a very topical one, it was one of the rare times a current president was actually mentioned during a Twilight Zone episode.

Perhaps best-known is the Keres Attack against the Scheveningen Variation of the Sicilian Defence ( 1. e4 c5 2. Nf3 d6 3. d4 cxd4 4. Nxd4 Nf6 5. Nc3 e6 6. g4 ), which was successfully introduced against Efim Bogolyubov at Salzburg 1943, and today remains a topical and important line.

7 ... Bg4 8. Be3 Nfd7 was a topical line from the 1950s through the mid 1970s.

Many famous evangelical preachers have used systematic exposition, though the line between exposition, topical message, and rabbit paths is not sharply defined.

The standard response for Black through the 1970s was 4 ... Bb7, but 4 ... Ba6 has since become the topical line.

He continued contributing to the New Yorker well into his eighties, displaying a talent for both graphic innovation ( many of his cartoons consisted of a single, unending line ) and for a wit that somehow combined the small issues of domestic life with a topical sensibility.

The intention of the conference is to address the topical main security issues and to debate and analyze the main security challenges in the presence and the future in line with the concept of networked security.

Jutting into the Humber estuary like a vast steel fin, the Deep is Hull's impressive new aquatic attraction-where you expect to find tropical fish rather than topical poetry-yet the first thing the visitor sees, before descending to the bottom of Europe's deepest tank, is a line by Stevenson: " The sea is as near as we come to another world.

White will now usually play 4 cxd5 exd5 5 Bf4 c6 6 e3, when 6 ... Bf5 7 g4 became a topical line after its adoption by Mikhail Botvinnik in his 1963 title match with Tigran Petrosian.

For example, in 1955 the line " Even Liberace, we assume, does it " was added by Noël Coward in his cabaret performance of the song although Coward's lyrics were entirely and completely rewritten as a topical piece, with none of Porter's lyrics remaining.

The plot line that brought the cast from the store to the manor was considered remarkably topical, since it aired just a few months after the death of British publishing tycoon Robert Maxwell, who was revealed to have borrowed heavily against his own employees ' pensions.

and, if they did not simply name their place Smith's Beer House, they would apply topical pub names in an effort to reflect the mood of the times.

Lance Percival would also sing a topical calypso each week.

Reduction of inflammation through the use of oral glucocorticoids such as, prednisone, followed by long term topical glucocorticoid nasal spray would easily and safely treat the anosmia.

" The opening to each show would see him deliver several minutes of topical jokes, and on one occasion where his autocue failed, he improvised a new and still topical routine.

At times the scripts would reflect topical realities of British life, such as rationing ( during the Suez Crisis ) and a specific railway strike.

The group would discuss topical issues selected by Maher, who also participated in the discussions.

The only other evidence are possible topical references within the play itself which would seem to indicate a date most likely in 1602 ,, however this is not universally accepted by all scholars.

The play contains a topical reference to the wars of succession in France which would fit any date from 1589 to 1595.

This refrain would soon appear in a very important composition, " Chimes of Freedom ", and, as biographer Clinton Heylin writes, " with this sad refrain, Dylan would pass from topical troubadour to poet of the road.

An example would be percutaneous drug absorption from topical medications.

In the 1902 stage adaptation, which is full of topical references that do not appear either in the novel or in any of the film adaptations ( unless they are satirical ), the Tin Woodman wonders what he would do if he ran out of oil.

Back as far as 1994 researchers were discussing new promising ideas such as topical lotions that would deliver ribozymes in a liposom cream.

Sometimes a topical subject ( for example, football ) would be put to each of them to offer their opinions.

Typologically there is a trend that highly animate actors are more likely to be topical than low-animate undergoers, this trend would come through even in free-word-order languages giving a statistical bias for SO order ( or OS in the case of ergative systems, however ergative systems do not usually extend to the highest levels of animacy, usually giving way to some form of nominative system at least in the pronominal system ).

As a result, what the manufacturer's marketing department chooses to list on the label of a topical medication might be completely different from what the form would normally be called.

The phone-in would present viewers with three options to the topical question, of which one would be phrased in a style similar to " I agree, but trivial phone opinion polls about such important issues are morally offensive.

Generally speaking, one would call a song " topical " only if the events referred to were at least reasonably recent at the time the song was written.

However, " Biko " by Peter Gabriel, written in 1980, three years after Steve Biko's death in a South African prison, would generally be considered topical because the anti-apartheid struggle of which Biko was part was still in full flower when the song was written.

When Allen was finally able to get a word in edgewise on the Senator, he would ask him a topical question, to which Claghorn would respond with a rapid stream of talk, shouting, repetition and punnery.

These were published by Edward Blount, and from topical references would appear to have been written about 1615.

It opens with Ward announcing in the style of a carnival barker, " Step right up, get your Republican talking points, get your peanut-size brains, your brain must be this ( various ) to go on this ride ," with ( various ) being a topical ad lib by Ward.

Cultured skin and prostate cancer cells showed significant mortality ( compared to nonmalignant cells ) when treated with a combination of quercetin and ultrasound Note that ultrasound also promotes topical absorption by up to 1, 000 times, making the use of topical quercetin and ultrasound wands an interesting proposition.

Also, it is used topically as a 4 % or 5 % gel or cream-as effective as topical 1 % clindamycin ( 8-week double-blind trial ) performed at the New York University College of Medicine.

The Weavers ' sound and repertoire of traditional folk material and topical songs directly inspired The Kingston Trio, a three-piece folk group who came to prominence in 1958 with their hit recording of " Tom Dooley ", which peaked at # 1 on the Billboard Hot 100 chart.

They were subsequently paired up with the partnership of Steve Punt and Hugh Dennis for a new topical comedy show for BBC Radio 1 called The Mary Whitehouse Experience, and its success led to a transfer to television which shot the quartet to fame.

Branded preparations are now available of topical nitroglycerine ointment ( Rectogesic ( Rectiv ) as 0. 2 % in Australia and 0. 4 % in UK and US ), topical nifedipine 0. 3 % with lidocaine 1. 5 % ointment ( Antrolin in Italy since April 2004 ) and diltiazem 2 % ( Anoheal in UK, although still in Phase III development ).

1: Aluminium Acetate topical ' solution: This is a colorless, with a faint acetous odour and sweetish taste.

Two examples of right-wing topical songwriters are Staff Sergeant Barry Sadler, whose " Ballad of the Green Berets " reached # 1 on the Billboard charts for five weeks in 1966 and was also Billboards # 1 single for that year ; and Toby Keith, who has written numerous songs in favor of aggressive U. S. military policies in reaction to the September 11, 2001 attacks.