Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e. g. Nuclear Factor-κB, Bcl-2 family proteins and murine double minute 2 ( MDM2 ).

Akt could phosphorylate BAD on Ser136, which makes BAD dissociate from the Bcl-2 / Bcl-X complex and lose the pro-apoptotic function.

The phosphatases in the PHLPP family, PHLPP1 and PHLPP2 have been shown to directly de-phosphorylate, and therefore inactivate, distinct Akt isoforms.

In 1955, Remarque wrote the screenplay for an Austrian film, The Last Act ( Der letzte Akt ), about Hitler's final days in the bunker of the Reich Chancellery in Berlin, which was based on the book Ten Days to Die ( 1950 ) by Michael Musmanno.

* Zdeněk Svěrák, Jiří Šebánek, Ladislav Smoljak – Akt ( English The Nude ), where the famous Czech fictional character Jára Cimrman was first introduced

This indirectly activates a protein kinase, PKB ( Akt ), via phosphorylation.

Hitler's last days have been depicted in several films, first in Der letzte Akt ( 1955 ), directed by Georg Wilhelm Pabst, starring Albin Skoda as the dictator ; next was the fifth and final installment of the Soviet film series Liberation ( 1969 – 72 ), directed by Yuri Ozerov, starring Fritz Diez ( an actor who commonly portrayed Hitler in a number of East German films from 1955 onwards ).

Akt von Michele de Falco ), 1712

Akt, also known as Protein Kinase B ( PKB ), is a serine / threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

Akt could also activate NF-κB via regulating IκB kinase ( IKK ), thus result in transcription of pro-survival genes.

Akt is associated with tumor cell survival, proliferation, and invasiveness.

Subsequently, phosphatidylinositol-3 kinase ( PI3K ) is activated, resulting in Akt kinase activation.

Finally, the Akt protein kinase promotes cell survival through two pathways.

Akt also activates IKKα, which leads to NF-κB activation and cell survival.

E., and Lei, M. Activation of Pak1 / Akt / eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.

Akt could promote growth factor-mediated cell survival both directly and indirectly.

Akt is known to play a role in the cell cycle.

Under various circumstances, activation of Akt was shown to overcome cell cycle arrest in G1 and G2 phases.

FOXOs are active, implying reduced Akt activity, in ∼ 40 % of AML patient samples regardless of genetic subtype ; and either activation of Akt or compound deletion of FoxO1 / 3 / 4 reduced leukemic cell growth in mouse model.

These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation.

Moreover, activated Akt may enable proliferation and survival of cells that have sustained a potentially mutagenic impact and, therefore, may contribute to acquisition of mutations in other genes.

Tumor cells that have constantly active Akt may depend on Akt for survival.

PTEN acts by opposing the action of PI3K, which is essential for anti-apoptotic, pro-tumorogenic Akt activation.

Die Berliner Tagung über den „ Akt von Gnesen “, Berlin 2002, S. 235 ff.

Moreover, a Cre-loxP recombination mouse model that lacks Crk and CrkL in most neurons was reported to have the reeler phenotype, indicating that Crk / CrkL lie between DAB1 and Akt in the reelin signaling chain.

* Der Akt des Lesens.

Trk dimerization and phosphorylation leads to activation of various intracellular signaling pathways including the MAP kinase, Akt, and PKC pathways.

Recently, it was shown that bile acids are able to induce intestinal differentiation, in gastroesophageal junction cells, through inhibition of the Epidermal growth factor receptor ( EGFR ) receptor which results in inhibition of Akt, upregulation of the p50 subunit of NF-κB ( NFKB1 ) and ultimately activation of the promotor of the homeobox gene CDX2.

Various kinases have been linked to DAT regulation including PKA, PKC, PI-3K, ERK1, ERK2, Akt, CaMKII, CDK5, and MAPK.

G-CSF regulates them using Janus kinase ( JAK )/ signal transducer and activator of transcription ( STAT ) and Ras / mitogen-activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase ( PI3K )/ protein kinase B ( Akt ) signal transduction pathway.

mTORC2 remains unaffected and responds by upregulating Akt, driving signals through the inhibited mTORC1.

Ghrelin has been shown to activate the endothelial isoform of nitric oxide synthase in a pathway that depends on various kinases including Akt.

Cimrman's theatre still possesses the original properties from the play Akt ( English: " The Nude "), through which the author himself left the stage.

Steroid hormone receptors can also function outside of the nucleus and couple to cytoplasmic signal transduction proteins such as PI3k and Akt kinase.

The post-war Akt Zjednoczenia Narodowego ( National Unity Act ) agreement among all the major political parties assumed that presidents were to choose their successors every seven years ; however, this was rejected by Zaleski.

Binding of IL-2 activates the Ras / MAPK, JAK / Stat and PI 3-kinase / Akt signaling modules.

The catalytic region or kinase core of the PKA allows for different functions to be processed ; PKB ( also known as Akt ) and PKC kinases contains approximately 40 % amino acid sequence similarity.

Regulation of Akt / PKB activity by P21-activated kinase in cardiomyocytes.

Egom, E. E., Ke, Y., Musa, H., Mohamed, T., Wang, T., Cartqright, E., Solaro, R. J., and Lei, M. FTY720 prevents ischemia / reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1 / Akt signaling.

The protein kinase Cdr2 ( which negatively regulates Wee1 ) and the Cdr2-related kinase Cdr1 ( which directly phosphorylates and inhibits Wee1 in vitro ) are localized to a band of cortical nodes in the middle of interphase cells.

CDK1, in turn, phosphorylates and modulates the activity of Wee1 and the Cdc25 isoforms A and C. Specifically, CDK1 phosphorylation inhibits Wee1 kinase activity, activates Cdc25C phosphatase activity, and stabilizes Cdc25A.