Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene.

Alpha-synuclein is a synuclein protein of unknown function primarily found in neural tissue, making up as much as 1 % of all proteins in the cytosol.

Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement.

Alpha-synuclein is known to directly bind to lipid membranes, associating with the negatively charged surfaces of phospholipids.

Alpha-synuclein primary structure is usually divided in three distinct domains:

Alpha-synuclein is the primary structural component of Lewy body fibrils.

Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease.

The claustrum in those with Parkinson's disease and dementia with Lewy bodies is often affected with Alpha-synuclein neuron inclusions called Lewy bodies and Lewy neurites and Beta amyloid.

Alpha-synuclein forms an extended helical structure on small unilamellar vesicles.

Alpha-synuclein has been shown to bend membranes of negatively charged phospholipid vesicles and form tubules from large lipid vesicles.

Parkin ( ligase ) has been shown to interact with STUB1, SEPT5, Alpha-synuclein, SNCAIP, SYT11, HSPA1A, Multisynthetase complex auxiliary component p38, CASK, CUL1, PDCD2, HSPA8, GPR37, FBXW7 and Ubiquitin C.

Tau protein has been shown to interact with FYN, Alpha-synuclein, YWHAZ and S100B.

It is possible, although highly doubtful, that he killed none at all but merely let his reputation work for him by privately claiming every unsolved murder in the state.

Only one rule prevailed in my conversations with these men: The more highly placed they are -- that is, the more they know -- the more concerned they have become.

All such imitations of negative quality have given rise to a compensatory response in the form of a heroic and highly individualistic humanism: if man can neither know nor love reality as it is, he can at least invent an artistic `` reality '' which is its own world and which can speak to man of purely personal and subjective qualities capable of being known and worthy of being loved.

nor is there need to add that among them are some of the most highly individualized and most successful of his characters.

Though versatile and capable of turning out a ballad lyric with the best of them, Mercer's forte is a highly polished quasi-folk wit.

A letter of a few days later from Washington's aide to Morgan stated, `` His Excellency is highly pleased with your conduct upon this occasion ''.

His approach to music is highly individualistic ; ;

Yet it is plainly time to make a start, and to be effective the first move should be highly dramatic, without being fanatical.

There is not anywhere on the frontiers of freedom a more highly mobilized force for liberation.

The fact that China ( which is obsessed by Formosa -- to Khrushchev a very small matter ) should be supported by North Korea and North Vietnam is highly indicative.

It is an answer in its way, individual and highly dramatic, to the charge that the democratic process is necessarily vicious in its campaign characteristics.

All nails should be rustproof, and aluminum is highly recommended.

For example, the officials of Poughkeepsie town ( township ) where the project is located think highly of it because it simplifies their snow clearing problem.

Fing, a lean, chiseled, impeccable gentleman of the old school who was once mistaken on the street for Sir Cedric Hardwicke, is responsible for the rediscovery of Verdi's earliest, most raucous opera, Nabisco, a sumptuous bout-de-souffle with a haunting leitmotiv that struck me as being highly reminiscent of the Mudugno version of `` Volare ''.

As is well known, detergent actives belong to the chemical class consisting of moderately high molecular weight and highly polar molecules which exhibit the property of forming micelles in solution.

This is particularly true of highly charged ions, especially those ions which fall into the class of polyelectrolytes.

Whereas the usual organic surface-active agent is strongly sorbed at oil - water interfaces, the highly charged ions are most strongly sorbed at interfaces between water and insoluble materials exhibiting an ionic structure ( see Table 26-2 on p. 1678 ).

This area is highly susceptible to infection.

An enemy would obviously choose an agent that is believed to be highly infectious.

It is, however, highly suggestive and agrees well with our own findings in which we also failed to demonstrate normally occurring bronchial artery-pulmonary artery shunts in certain species, especially the dog.

There is no conclusive evidence yet that either of the proteases has been prepared in highly purified form nor is their specificity known.

And it is expressed, at least to their taste, in a perfect form.

we accord it its place there, and in Lawrence's treatment we are given the innocent fantasy of a child, in fact, the form in which oedipal love is expressed in childhood.

It is at least possible that the capacity to postpone gratification is developed as well as expressed in a continuous and guided exposure to great literature.

Again, Henley's attitude of defiance which colors his ideal of self-mastery is far from characteristic of a Stoic thinker like Marcus Aurelius, whose gentle acquiescence is almost Christian, comparable to the patience expressed in Milton's sonnet on his own blindness.

As to our action, let us align ourselves with the purpose expressed by Jesus in the Lord's Prayer: `` Thy kingdom come, Thy will be done, on earth as it is in heaven ''.

It occurred to me that you might be interested in some thoughts which I expressed privately in recent years, in the hope of clearing up a certain confusion in the public mind about what foreign policy is all about and what it means, and of developing a certain compassion for those who are carrying such responsibilities inside Government.

If we sit here reading editorials and looking at public-opinion polls and other reports that cross our desks, we should realize that this is raw, undigested opinion expressed in the absence of leadership.

For this reason, the more uncertain skywave service was denominated `` secondary '' in our rules, as compared to the steadier, more reliable groundwave `` primary service '', and, for both skywave service and skywave interference, signal strength is expressed in terms of percentage of time a particular signal-intensity level is exceeded -- 50 percent of the time for skywave service, 10 percent of the time for skywave interference.

The size of the press is usually expressed in terms of chuck capacity ( the maximum diameter tool shank it will hold ) or distance between the spindle center and the column.

It is also expressed in the proscription against deviants in the matter of endogamy, particularly in rural areas.

When a word represents a larger construction of which it is the only expressed part, it normally has more stress than it would have in fully expressed construction.

Finally, there is the question of how strongly an expressed opinion is held -- whether it is a firm opinion or one that the respondent favors only slightly over the alternatives.

The reaffirmation of American faith in the comprehensive high school, as expressed in the Conant study, is another indication of the liveliness of the ideal of maximizing opportunity through the equalizing of educational opportunity.

In the only sense in which badness is involved at all, whatever was bad in the first case is still present in its entirety, since all that is expressed in either case is a state of feeling, and that feeling is still there.

In these circumstances, since what was expressed by the remark when first made is, on the theory before us, simply absent, the remark now expresses nothing.