Although rare, deposits of native chromium exist.

Although female roles were performed by castrati in some of the papal states, this was increasingly rare ; by 1680, they had supplanted " normal " male voices in lead roles, and retained their position as primo uomo for about a hundred years ; an Italian opera not featuring at least one renowned castrato in a lead part would be doomed to fail.

Although this is a relatively rare instance of a female Confucian voice, Ban Zhao almost entirely accepts the prevailing views concerning women's proper roles ; they should be silent, hard-working, and compliant.

Isidore of Miletus and Anthemius of Tralles originally planned on a main hall of the Hagia Sophia that measured 230 feet by 250 feet, making it the largest church in Constantinople, but the original dome was nearly 20 feet lower than it was constructed, “ Justinian suppressed these riots and took the opportunity of marking his victory by erecting in 532-7 the new Hagia Sophia, one of the largest, most lavish, and most expensive buildings of all time .” Although Isidore of Miletus and Anthemius of Tralles were not formally educated in architecture, they were scientists that could organize the logistics of drawing thousands of laborers and unprecedented loads of rare raw materials from around the Roman Empire to create the Hagia Sophia for Emperor Justinian I.

Although carbonaceous chondrites are thought to be rare, some are very large and the suspected " dinosaur-killer " may have been a carbonaceous chondrite.

Although lanthanum belongs to the element group called rare earth metals, it is not rare at all.

Although its FPU performance fit scientific users quite well, its limited integer performance and high cost dampened appeal for most users, and the R8000 was in the marketplace for only a year and remains fairly rare.

Although neon is a very common element in the universe and solar system ( it is fifth in cosmic abundance after hydrogen, helium, oxygen and carbon ), it is very rare on Earth.

Although neodymium is classed as a " rare earth ", it is no rarer than cobalt, nickel, and copper ore, and is widely distributed in the Earth's crust.

Although it belongs to the rare earth metals, neodymium is not rare at all.

Although rare now, in the past there were bowlers who used the off-break action who deliberately did not impart any considerable spin on the ball but relied on line and length to frustrate batsmen.

Although in practice such instances are rare, they do exist.

Although encountering the flaw was extremely rare in practice ( Byte magazine estimated that 1 in 9 billion floating point divides with random parameters would produce inaccurate results ),< ref > both the flaw and Intel's initial handling of the matter were heavily criticized.

Although classified as a rare earth element, samarium is the 40th most abundant element in the Earth's crust and is more common than such metals as tin.

Although in rare cases, a court may change the terms of the trust due to unexpected changes in circumstances that make the trust uneconomical or unwieldy to administer, under normal circumstances an irrevocable trust may not be changed by the trustee or the beneficiaries of the trust.

Although the acute porphyrias may cause episodes of confusion and psychiatric disturbance, dementia is a rare feature of these rare diseases.

Although plantain and banana allergy is not among the top five food allergies, it cannot be considered as a rare allergy, neither in children nor in adults.

Although the standards permit any type of environment, it is fairly rare to see low level languages like C used.

Although rare, such cases do exist and may sometimes be referred to as mixed-endian or middle-endian.

Although the great white is typically regarded as an apex predator in the wild, it is in rare cases preyed upon by the larger orca ( also known as the killer whale ).

Although corals first appeared in the Cambrian period, some, fossils are extremely rare until the Ordovician period, 100 million years later, when rugose and tabulate corals became widespread.

Although < sup > 4 </ sup > He continues to be produced by other mechanisms ( such as stellar fusion and alpha decay ) and trace amounts of < sup > 1 </ sup > H continue to be produced by spallation and certain types of radioactive decay ( proton emission and neutron emission ), most of the mass of these isotopes in the universe, and all but the insignificant traces of the < sup > 3 </ sup > He and deuterium in the universe produced by rare processes such as cluster decay, are thought to have been produced in the Big Bang.

Although gene therapy is still relatively new, it has had some successes.

Although early clinical failures led many to dismiss gene therapy as over-hyped, clinical successes in 2006-2011 have bolstered new optimism in the promise of gene therapy.

Although introns are sometimes called intervening sequences, the term " intervening sequence " can refer to any of several families of internal nucleic acid sequences that are not present in the final gene product, including inteins, untranslated sequences ( UTR ), and nucleotides removed by RNA editing, in addition to introns.

Although it has morphological similarities with the pygmy killer whale, the false killer whale and the pilot whales, a study of cytochrome b gene sequences by Richard LeDuc indicated that its closest extant relatives are the snubfin dolphins of the genus Orcaella.

Although a complete theory of evolution also requires an account of how genetic variation arises in the first place ( such as by mutation and sexual reproduction ) and includes other evolutionary mechanisms ( such as genetic drift and gene flow ), natural selection appears to be the most important mechanism for creating complex adaptations in nature.

Although the practicality of this approach to gene therapy has yet to be proven, some aspects of it could be less problematic than the alternative viral-based delivery of therapeutic genes.

Although the north-west population is less genetically diverse overall, it has higher MHC gene diversity, which allows them to mount an immune response to DFTD.

Although most people without CF have two working copies of the CFTR gene, only one is needed to prevent cystic fibrosis due to the disorder's recessive nature.

Although most people have two working copies ( alleles ) of the CFTR gene, only one is needed to prevent cystic fibrosis.

Although many researchers have found autosomal and mitochondrial genetic risk factors for SIDS, they cannot explain the male excess because such gene loci have the same frequencies for males and females.

Although very early in development, gene therapy has restored a sense of smell in mice with congenital anosmia when caused by ciliopathy.

Although the genetic mutation causing the short-legged trait in Munchkins has been referred to as achondroplasia, it has not been proven that the trait is due to a gene at the same locus as causing achondroplasia in humans.

Although Haplogroup K is common throughout western Eurasia, " the observed global pattern of distribution renders very unlikely the possibility that the four aforementioned founder lineages entered the Ashkenazi mtDNA pool via gene flow from a European host population:

Although examples of horizontal gene transfer are apparent in LuxI, LuxR, and LuxS phylogenies, they are relatively rare.

Although the origin of this mutation is unknown, it is presumed that the constant pairing of related birds and selective breeding led to recessive gene combinations leading to genetic conditions including albinism.

Although there is no direct evidence of a Shh gradient, there is indirect evidence via the visualization of Patched ( Ptc ) gene expression, which encodes for the ligand binding domain of Shh receptor, throughout the ventral neural tube.

Although he is not a witch, he carries the witch gene.

Although its discoverers dubbed this gene the adipose gene, it is not a gene responsible for creating adipose tissue.

Although over 1500 mutations are known in the CFTR gene, by far the most common mutant is DF508.

Although not initially intended recombinant protein manufacture, DHFR-minus CHO cells were used for a number of pioneering experiments demonstrating stable transfection with an exogenous dhfr gene via selection in GHT-minus medium ( Ringold et al., 1981 ; Kaufman and Sharp, 1982 ; Scahill et al., 1983 ).

Although a functional gene product can be an RNA, the majority of known mechanisms regulate protein coding genes.

Although as early as 1951 Barbara McClintock showed interaction between two genetic loci, Activator ( Ac ) and Dissociator ( Ds ), in the color formation of maize seeds, the first discovery of a gene regulation system is widely considered to be the identification in 1961 of the lac operon, discovered by Jacques Monod, in which some enzymes involved in lactose metabolism are expressed by the genome of E. coli only in the presence of lactose and absence of glucose.