By November 2004, there had been two double-blind placebo-controlled crossover trials, and a 25, 000 + patient open-label study lasting over seven years, all showing effectiveness.

There is an extensive body of clinical data demonstrating the safety and effectiveness of TMS in treating major depression in patients who have not received benefit from antidepressant medication including 2 randomized, controlled multicenter trials, 2 open-label extension studies, and a 6 month post-treatment durability study.

Additional efficacy data is provided from an open-label follow-on study which demonstrated that one out of two patients responded (> 50 % decrease in symptoms ) to open-label TMS and one of three patients achieved complete remission of symptoms.

This study concluded that "... daily left prefrontal TMS as monotherapy produced significant and clinically meaningful antidepressant therapeutic effects greater than sham ..." A follow-on open-label extension study for the NIMH-sponsored trial reported similar outcomes to those observed in the company sponsored open-label study.

A later open-label study of general practice patients, funded by Pfizer, found that sertraline had equal efficacy in melancholic vs. non-melancholic patients, as well as in previous TCA non-responders vs. all other patients.

Recently Chemgenex released results of their open-label Phase 2 / 3 study ( CGX-635-CML-202 ) which investigated the use of their non-targeted agent omacetaxine, administered subcutaneously in CML patients who had failed imatinib and who have the highly drug-resistant T315I kinase domain mutation.

An earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms.

Hewlett and others found that the treatment of obsessive compulsive disorder with Ondansetron 1 mg three times daily was associated with a significant decrease in the Yale Brown Obsessive Compulsive scores in a small ( n = 8 ), 8-week, open-label study.

A completed Phase II, multi-centre, single-arm, open-label study evaluated the efficacy and safety of Revlimid monotherapy treatment for achieving haematopoietic improvement in red blood cell ( RBC ) transfusion dependent subjects with low-or intermediate-1-risk MDS associated with a deletion 5q cytogenetic abnormality.

The results of this trial show that real world outcomes with TMS are similar to those obtained in prior TMS open-label trials.

An open-label trial may still be randomized.

In a six-month open-label trial involving three medical centers in Australia, Mexico, and Norway, vagus nerve blocking has helped 31 obese participants lose an average of nearly 15 percent of their excess weight.

An open-label trial or open trial is a type of clinical trial in which both the researchers and participants know which treatment is being administered.

An open-label trial may be unavoidable under some circumstances, such as comparing the effectiveness of a medication to intensive physical therapy sessions.

Technical trading strategies were found to be effective in the Chinese marketplace by a recent study that states, " Finally, we find significant positive returns on buy trades generated by the contrarian version of the moving-average crossover rule, the channel breakout rule, and the Bollinger band trading rule, after accounting for transaction costs of 0. 50 percent.

A subsequent randomized crossover study showed benefit by avoiding eating two hours before bedtime.

Educational theorists like Sidney Hook and John Dewey ( see pragmatism ) disagreed with the premise that there was crossover in education ( e. g. that a study of philosophy, formal logic, or rhetoric could be of use in medicine or economics ).

A double-blind, placebo-controlled, crossover pilot study of 11 adult human subjects showed that starch absorption averaged 66 % less in the group taking Phase 2.

This is unlike a crossover study where at first one group receives treatment A and later followed by treatment B while the other group receives treatment B followed by treatment A.

A recent study concluded that Bollinger Band trading strategies may be effective in the Chinese marketplace, stating: " Finally, we find significant positive returns on buy trades generated by the contrarian version of the moving-average crossover rule, the channel breakout rule, and the Bollinger Band trading rule, after accounting for transaction costs of 0. 50 percent.

Dr. Raskind and colleagues studied the efficacy of prazosin for PTSD among ten Vietnam combat veterans in a 20-week double-blind crossover study with a two-week drug washout to allow for return to baseline.

Managers aim to capture the inefficiencies arising from the heavy participation of non-economic investors ( i. e., high income " buy and hold " investors seeking tax-exempt income ) as well as the " crossover buying " arising from corporations ' or individuals ' changing income tax situations ( i. e., insurers switching their munis for corporates after a large loss as they can capture a higher after-tax yield by offsetting the taxable corporate income with underwriting losses ).

Although he broke through as a crossover artist with white audiences ( appearing at the Alan Freed concerts, for example ), he rarely tailored his compositions to teenage concerns.

In 1975, Bowie achieved his first major American crossover success with the number-one single " Fame " and the hit album Young Americans, which the singer characterised as " plastic soul ".

* The point at which the device comes closest to being cut off is not close to zero signal, so the problem of crossover distortion associated with class-AB and-B designs is avoided.

Film theory is not to be confused with general film criticism, though there can be some crossover between the two disciplines.

; The Forgotten Futures Compendium: Two long adventures, Curse of the Leopardmen by Alex Stewart and The League of Extraordinary Geometers ( a crossover with The Original Flatland RPG ) by Marcus Rowland, plus adventure outlines based on Victorian and Edwardian advertising by Marcus Rowland.

* A binary symmetric channel ( BSC ) with crossover probability p is a binary input, binary output channel that flips the input bit with probability p. The BSC has a capacity of bits per channel use, where is the binary entropy function to the base 2 logarithm:

In the Age of Apocalypse crossover event, Bobby, along with the rest of the X-Men, is trained by Magneto.

* Jeep Patriot: Five passenger compact crossover with traditional SUV styling.

Influenced by the crossover success of Ray Charles, Brown backed away from his musical roots and incorporated productions of pop standards, finding success with his first Top 20 single, " Prisoner of Love ".

The final addition was the " crossover " 6510, used in the Commodore 64, with additional I / O ports.

This serves to bias the two output transistors slightly into conduction reducing crossover distortion ( in some discrete component amplifiers, this function is usually achieved with a string of two silicon diodes ).

Variations in the bias with temperature, or between parts with the same type number, are common so crossover distortion and quiescent current may be subject to significant variation.

Some subfields of modern phonology have a crossover with phonetics in descriptive disciplines such as psycholinguistics and speech perception, resulting in specific areas like articulatory phonology or laboratory phonology.

After a giant crossover with Freunde fürs Leben, Forsthaus Falkenau and Unser Lehrer Doktor Specht, the soap opera got canceled after 313 episodes.

Crow duetted with rapper Kid Rock on the crossover hit single " Picture.

Such successful " crossover " titles remain the exception rather than the rule, however: the archetypal shōjo manga magazine Hana to Yume has a readership 95 % female, with a majority aged 17 or under.

It is a seven-movement work that is best known for the classical crossover series Adiemus, which intersperses movements reflecting the themes of David's last sermon with those drawing from three Psalms.

In the comic crossover X-Men / Star Trek: Second Contact, the X-Men work with the crew of the Enterprise-E to battle Kang the Conqueror.

The series deals with the group's attempt to unravel the truth behind the Decimation and its aftermath, getting involved with the events of Marvel's crossover Civil War, fighting with Singularity Investigations, and dealing with Madrox's powers and their consequences.