Also Atorvastatin should be discontinued if a patient has markedly elevated CPK levels or if a myopathy is suspected or diagnosed.

Atorvastatin undergoes rapid oral absorption, with an approximate time to maximum plasma concentration ( T < sub > max </ sub >) of 1 – 2 hours.

File: Atorvastatin. svg | Lipitor, a blockbuster drug featuring two phenyl and one p-fluorophenyl groups.

In June 2008, Ranbaxy settled the patent dispute with Pfizer allowing them to sell Atorvastatin Calcium, the generic version of Lipitor < sup >( R )</ sup > and Atorvastatin Calcium-Amylodipine Besylate, the generic version of Pfizer's Caduet < sup >( R )</ sup > in the US starting November 30, 2011.

Atorvastatin ( INN ) (), marketed by Pfizer as a calcium salt under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol.

Atorvastatin is absolutely contraindicated in pregnancy, it is likely to cause harm to fetal development because of the importance of cholesterol and various products in the cholesterol biosynthesis pathway for fetal development, including steroid synthesis and cell membrane production.

Atorvastatin and other statins are associated with anecdotal reports of memory loss by consumers, which have been seen in clinical practice in a tiny percentage of users, particularly women.

High-dose atorvastatin had also been associated with worsening glycemic control in the Pravastatin or Atorvastatin Evaluation and Infection Therapy – Thrombolysis In Myocardial Infarction 22 ( PROVE-IT TIMI 22 ) substudy.

Co-administration of Atorvastatin with one of CYP3A4 inhibitors like itraconazole, telithromycin and voriconazole, may increase serum concentrations of atorvastatin, which may lead to adverse reactions.

Atorvastatin undergoes high intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability.

Atorvastatin is also an inhibitor of cytochrome 3A4.

Atorvastatin is also a substrate of the intestinal P-glycoprotein efflux transporter, which pumps the drug back into the intestinal lumen during drug absorption.

Atorvastatin and its active metabolites may be monitored in potentially-susceptible patients using specific chromatographic techniques.

Atorvastatin calcium tablets are marketed by Pfizer under the trade name Lipitor for oral administration.

DSM Sinochem Pharmaceuticals produces penicillin G and penicillin intermediates ( 6-APA and 7-ADCA ), active pharmaceutical ingredients such as semisynthetic penicillins and semi-synthetic cefalosporins ( beta-lactams ) and other active pharmaceutical ingredients such as Nystatin and Atorvastatin.

In 2010, the family-controlled Dr Reddy's denied that it was in talks to sell its generics business in India to US pharmaceutical giant Pfizer, which had been suing the company for alleged patent infringement after Dr Reddy's announced that it intended to produce a generic version of Atorvastatin, marketed by Pfizer as Lipitor, an anti-cholesterol medication.

* MedlinePlus Drug information: Atorvastatin ( Systemic ) – information from USP DI Advice for the Patient

Atorvastatin is highly protein bound (≥ 98 %).

The `` approximate '' is important, because even after the order of the work has been established by the chance method, the result is not inviolable.

Although the Church of the Holy Sepulchre has its tomb just a few yards away from its Golgotha, there is no particular reason to regard this close juxtaposition as a necessity ; however, Gordon followed this principle, concluding that his site for Golgotha must also be the approximate location for Jesus ' burial, identifying a nearby tomb, now called the Garden Tomb, as the location for the event.

If a throw lands out of bounds, unless defined by the hole, the thrower has the option of playing from the previous lie, or playing from the approximate spot where the disc crossed into the out-of-bound territory.

Conversely, if the data are sparse — that is, if only K out of N Fourier coefficients are nonzero — then the complexity can be reduced to O ( K log N log ( N / K )), and this has been demonstrated to lead to practical speedups compared to an ordinary FFT for N / K > 32 in a large-N example ( N = 2 < sup > 22 </ sup >) using a probabilistic approximate algorithm ( which estimates the largest K coefficients to several decimal places ).

Further analysis has provided an approximate date for his prophecy and possibilities concerning his activities and background.

With an approximate 50: 50 front / rear weight balance, the car has nearly neutral handling.

From Louisville, the river loses depth very gradually until its confluence with the Mississippi at Cairo, Illinois, where it has an approximate depth of.

Since the strong interaction does not discriminate between different flavors of quark, QCD has approximate flavor symmetry, which is broken by the differing masses of the quarks.

It has an approximate composition of SeS < sub > 2 </ sub >, with individual rings varying in composition, such as Se < sub > 4 </ sub > S < sub > 4 </ sub > and Se < sub > 2 </ sub > S < sub > 6 </ sub >.

Jerrum, Valiant, and Vazirani showed that every # P-complete problem either has an FPRAS, or is essentially impossible to approximate ; if there is any polynomial-time algorithm which consistently produces an approximation of a # P-complete problem which is within a polynomial ratio in the size of the input of the exact answer, then that algorithm can be used to construct an FPRAS.

* February 14 – Pope Gelasius I introduces Valentine's Day, after he has abolished Lupercalia ( approximate date ).

* Boethius, Roman philosopher, is executed without trial, probably at Pavia, after a prison term during which he has written the " Consolation of Philosophy " ( approximate date ).

* November 10 – Pope Leo I dies at Rome, age 61 ( approximate ), after a 21-year reign in which he has resisted Manichaeism and defended the Church against Nestorianism.

* Spanish Jew Benjamin of Tudela reports that Constantinople has merchant communities from Babylon, Canaan, Egypt, Hungary, Persia, Russia, Sennar, and Spain as well as 2, 000 Jews ( approximate date ).

The UNECE secretariat headquarters is in Geneva, Switzerland, and has an approximate budget of US $ 50 million.

Since then, the approximate region he identified has become known as Broca's area, and the deficit in language production as Broca's aphasia.

This equation, though approximate, has been shown to give good estimates on the motion of the bubble under the acoustically driven field except during the final stages of collapse.

The Erlenmeyer is usually marked on the side ( graduated ) to indicate the approximate volume of contents, and has a spot of ground glass or enamel where it can be labeled with a pencil.

The hydraulic analogy to Ohm's law has been used, for example, to approximate blood flow through the circulatory system.

There is also a rare variety of Turner Syndrome, known as " Ring-X Turner Syndrome ", which has an approximate 60 percent association with mental retardation.

** Gaius Laelius, Roman general and politician who has been involved in Rome's victory during the Second Punic War between Rome and Carthage ( approximate date )

** Titus Quinctius Flamininus, Roman general and statesman whose skillful diplomacy has enabled him to establish a Roman protectorate over Greece ( b. c. 227 BC ) ( approximate date )

The methane in clathrates typically has a biogenic isotopic signature and highly variable δ < sup > 13 </ sup > C (- 40 to-100 ‰), with an approximate average of about-65 ‰ .< ref name =" Matsumoto 1995 "> Below the zone of solid clathrates, large volumes of methane may occur as bubbles of free gas in the sediments.

The approximate position of the maximum has been illuminated.

A weak acid has a pK < sub > a </ sub > value in the approximate range − 2 to 12 in water.