Corticotropin-releasing hormone ( CRH ), originally named corticotropin-releasing factor ( CRF ), and also called corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response.

Corticotropin-releasing hormone ( CRH ) is a 41-amino acid peptide derived from a 191-amino acid preprohormone.

CRH is secreted by the paraventricular nucleus ( PVN ) of the hypothalamus in response to stress.

In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta.

In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery.

CRH is produced by parvocellular neuroendocrine cells ( which are contained within the paraventricular nucleus ) of the hypothalamus and is released at the median eminence from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system.

CRH is also synthesized by the placenta and seems to determine the duration of pregnancy.

In culture, trophoblast CRH is inhibited by progesterone, which remains high throughout pregnancy.

CRH is transported to the anterior pituitary through the portal blood vessel system of the hypophyseal stalk and vasopressin is transported by axonal transport to the posterior pituitary.

Release of CRH from the hypothalamus is influenced by stress, physical activity, illness, by blood levels of cortisol and by the sleep / wake cycle ( circadian rhythm ).

This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH ( Corticotropin releasing hormone ) ( tertiary hypercortisolism / hypercorticism ).

Corticotropin-releasing hormone ( CRH ) is a hormone found mainly in the paraventricular nucleus of the mammalian hypothalamus which regulates the release of corticotropin ( ACTH ) from the pituitary gland.

CRH is evolutionary related to a number of other active peptides.

This is called secondary adrenal insufficiency and is caused by lack of production of ACTH in the pituitary or lack of CRH in the hypothalamus.

Release of corticotropin-releasing hormone ( CRH ) from the hypothalamus is influenced by stress.

* CRH is a major regulator of the HPA axis / stress axis.

* CRH is widely distributed in the brain and periphery

: CRH is also the acronym for Irish company Celtic Resources Holdings plc, a mining company

CRH plc (,,, ) is an Irish diversified building materials company, which manufactures and distributes building material products from the fundamentals of heavy materials and elements to construct the frame, through exterior products that complete the building envelope, to distribution channels, which service construction fit-out and renewal.

CRH has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index.

In 2005, the current Minister for Environment Phil Hogan stated in Dail Eireann that “ there is a widespread problem with competition in this economy ……… In the case of CRH, profits have been extracted from the Irish economy by means of a complex industry structure that is both anti-competitive and anti-consumer.

This reduces the secretion of CRH and vasopressin, and also directly reduces the cleavage of proopiomelanocortin ( POMC ) into ACTH and β-endorphins.

Addison's disease should also be distinguished from secondary and tertiary adrenal insufficiency, which are caused by deficiency of ACTH ( produced by the pituitary gland ) and CRH ( produced by the hypothalamus ), respectively.

* Vasopressin, which also regulates ACTH secretion ( vasopressin and CRH act synergistically to stimulate ACTH secretion )

* CRH also regulates the actions of the Autonomic nervous system ANS and immune system.

Charles J. Haughey was also offered chairmanship of CRH in 1972.

ACTH partially regulates adrenal androgen secretion, also CRH.

The top operational commercial speed of this train is, making it the world's fastest train in regular commercial service since its opening in 2004, faster than TGV in France and also faster than the latest CRH conventional wheel train in China at.

It also offers over 50 highspeed CRH trains to those areas every day.

The CRH is extending and repairing track northwards from Llynclys South towards Oswestry, to enable trains to run back into the former CR head quarters.

* Crouch Hill railway station, a railway station in England ( National Rail station code: CRH )

Administration of corticotropin releasing hormone ( CRH ) can differentiate this condition from ectopic ACTH secretion.

The concept of multiple unit has entered the horizon of the Chinese since the 6th Speed-up Campaign of China Railways in 2007. With the upgrade of Jinghu Railway, North Jingguang Railway, Jingha Railway and Hukun Railway, and the construction of new Passenger Dedicated Lines ( or Passenger Railways ) completed, CRH ( China Railway High-speed ) trains have been put into service, mainly in North and Northeast China, and East China.

Just two companies, Ryanair and CRH plc ( which has its primary listing in London ), account for the bulk of the day-to-day share dealing on the exchange since the collapse of Irish banking stocks.

* Central mediated since peripheral administration of CRH antagonist does not affect immunosuppression.

In 2006 CRH struck out from its usual strategy and invested in a cement factory based in the Heilongjiang region in China.

In 2006, an antitrust lawsuit was filed against Oldcastle Precast ( CRH subsidiary ) and three AT & T affiliates.

Marked reduction in CRH has been observed in association with Alzheimer's disease, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis.

A new model has recently surfaced in the literature regarding the HPA Axis and its involvement with dysthymia ( e. g. phenotypic variations of corticotropin releasing hormone ( CRH ) and arginine vasopressin ( AVP ), and down-regulation of adrenal functioning ) as well as forebrain serotonergic mechanisms.

CRH has been shown to interfere with dendritic growth and differentiation.

From the business community, alumni include: Kerry Group's Denis Brosnan, Kingfisher plc's CEO Gerry Murphy, and former head of CRH Anthony Barry.

In 2005, a Polish Parliamentary Inquiry was told that CRH paid a bribe of almost $ 1 million to a former minister for privatisation, Wieslaw Kaczmarek, in connection with the privatisation of a cement plant at Ozarow, in central Poland, in 1995.

In 2003, CRH was accused of making corrupt payments to Ireland ’ s former Taoiseach ( Prime Minister ) Charles J. Haughey as details emerged of how Mr. Haughey received crooked payments from various companies and businessmen in return for political favours.

Eight out of fifteen CRH directors held Ansbacher accounts, including four former Chairmen.