Colistin ( polymyxin E ) is a polymyxin antibiotic produced by certain strains of Bacillus polymyxa var.

Colistin is a mixture of cyclic polypeptides colistin A and B. Colistin is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic.

Colistin sulfate is cationic ; colistimethate sodium is anionic.

Colistin sulfate is stable, but colistimethate sodium is readily hydrolysed to a variety of methanesulfonated derivatives.

Colistin sulfate is also used as topical creams, powders, and otic solutions.

Colistin sulfate and colistimethate sodium may both be given intravenously, but the dosing is complicated.

Colistin has been used in combination with rifampicin, and there is in-vitro evidence of synergy, and the combination has been used successfully in patients.

Colistin is polycationic and has both hydrophilic and lipophilic moieties.

New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin.

Colistin was derived from a flask of fermenting bacteria by a Japanese researcher in 1949.

Colistin sulfate and colistimethate sodium are eliminated from the body by different routes.

* Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora.

This is a decades-old stereotype stemming from the Wall Street establishment's protection of its interests, and the link to the WASP establishment.

The town is also in the process of constructing a new municipal center to replace the decades-old, antiquated facility.

Fenton is now open and working to stay open ; tours are run daily through the gift shop and orders are placed online, on QVC and via its decades-old collector-quality catalog.

The Little House series is based on decades-old memories of Laura Ingalls Wilder's childhood in the Midwest region of the United States during the late 19th century.

The site, while recognized as a Hopi traditional cultural property, is on land now owned by the Navajo Indians, the result of a decades-old dispute that saw these neighboring tribes fighting over land each considered its own.

18, 988 ) is located on a peninsula on the extreme eastern part of the island, one of the least developed municipalities and severely devastated by the decades-old armed conflicts plaguing the island

Development is a passionate issue for Bay Ridge residents, as in recent years they saw many of the decades-old two-family houses being demolished, replaced by condominiums known colloquially as " Fedder Homes ," after the branded air conditioners poking out from the buildings ' facades.

Local business leaders in San Francisco's Fisherman's Wharf district said they opposed every other fast food chain except In-N-Out, because they wanted to maintain the flavor of family-owned, decades-old businesses in the area, with one saying locals would ordinarily " be up in arms about a fast-food operation coming to Fisherman's Wharf ," but " this is different.

* " Within the Walls of Tyre ," a 1978 World Fantasy Award-nominated short story by Michael Bishop, is about a woman who secretly cherishes her decades-old lithopedion.

The computer also reveals what is apparently the Enterprises mission: According to the orders, the Enterprise is part of a fleet of vessels fighting a decades-old war with the Lysians.

One of the disputes between Frasier and Martin is a decades-old, well-worn recliner that Martin owns ; Frasier is appalled by its appearance in his living room.

Any following reallocation of tram classes between depots, including the mooted retirement of the unpopular ( due to numerous noise and ongoing safety / maintenance issues ) and now more than four decades-old Z1 / 2 class trams, is currently in a state of contention until plans are formally announced.

* As is the case with all collectibles, condition greatly affects the value of comic books, although considerable wear is expected for decades-old comics.

He is also known for his decades-old feud with the superhuman hit man Tombstone, with whom he attended high school.

* In the short story " The Man Who Got Off The Ghost Train ", Richard Jeperson is dispatched to investigate a decades-old mystery in which Colonel Moran played a brief but memorable part.

But it looks to me like pharm party is just a new label the drug-abuse industrial complex has adopted to describe the decades-old tradition of pill parties.

But is that not like going to a chemistry laboratory and blindly pouring out liquids and powders from an array of bottles and then, after stirring, expecting a new wonder drug inevitably to result??

There is every reason to recognize that in the very last years of his life, as we shall see, Thompson did take the drug in carefully rationed doses to ease the pains of his illness, but the exact date at which this began has never been determined.

This indicates that this drug is being marketed under one trade name only or state regulatory organizations have approved its use on the feed tag.

The drug is also incorporated in supplements.

For treatment of bloat, drug is fed at a higher level.

It is believed that drug therapy and electroshock involve the former and psychotherapy the latter mechanism.

And this is only natural -- witness the haste with which modern man gobbles the latest `` wonder drug ''.

To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria is inhibited by the drug.

One strategy to address bacterial drug resistance is the discovery and application of compounds that modify resistance to common antibacterials.

Antibiotic resistance is a type of drug resistance where a microorganism is able to survive exposure to an antibiotic.

* In the film Equilibrium, an arcology named Libria is the last human civilization, a society in which peace is kept by the forced administration of an injected liquid drug designed to completely suppress emotions.

This fact makes therapeutic target development extremely difficult – a drug that harms an apicomplexan parasite is also likely to harm its human host.

Internationally, DMT is a Schedule I drug under the Convention on Psychotropic Substances.

However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug.

Religious use in Brazil was legalized after two official inquiries into the tea in the mid-1980s, which concluded that ayahuasca is not a recreational drug and has valid spiritual uses.

It is believed that the gift was an opium-containing drug.

In 1804, the German chemist Friedrich Sertürner isolated from opium a " soporific principle " (), which he called " morphium " in honor of Morpheus, the Greek god of dreams ; in German and some other Central-European languages, this is still the name of the drug.

Analytical chemistry plays an increasingly important role in the pharmaceutical industry where, aside from QA, it is used in discovery of new drug candidates and in clinical applications where understanding the interactions between the drug and the patient are critical.

Another extrinsic pathway for initiation identified in several toxin studies is an increase in calcium concentration within a cell caused by drug activity, which also can cause apoptosis via a calcium binding protease calpain.

The Gulf News published on 30 November 2011, saying " This is the biggest drug bust of its kind in 2011 and the second big one in the last three years worldwide ," said Dr. Wadia Maalouf, International expert at the United Nation's Drug and Crime office.

An anti-diarrhoeal drug ( or anti-diarrheal drug ( American English )) is any medication which provides symptomatic relief for diarrhoea.