Disadvantages include a smaller volume, even though many or most unfretted instruments tend to be significantly larger than fretted instruments ; and many more strings to keep in tune.

Disadvantages include its classification as a possible carcinogen.

Disadvantages include the vapour produced by the solvent and the need to dispose of used solvent.

Disadvantages compared to tank plating can include greater operator involvement ( tank plating can frequently be done with minimal attention ), and inability to achieve as great a plate thickness.

Disadvantages of such shutters are their inability to reliably produce very fast shutter speeds ( faster than 1 / 500th second or so ) and the additional cost and weight of having to include a shutter mechanism for every lens.

Disadvantages include combustibility ( hard to extinguish ) and significant smoke development.

Disadvantages include the need for procedures on the woman, and the standard potential side-effects of IVF for both the mother and the child.

Disadvantages of simultaneous spectrometers include relatively high cost for complex analyses, since each channel used is expensive.

Disadvantages include the inability to create crystals with dimensions of a comparable size to their natural counterparts.

Disadvantages to turn lanes include increased pavement area, with associated increases in construction and maintenance costs, as well as increased amounts of stormwater runoff.

Disadvantages of using dry pipe fire sprinkler systems include:

Disadvantages include a lack of bass response ( due to phase cancellation from a lack of enclosure ( bass rolloff 3db point occurs when the narrowest panel dimension equals a quarter wavelength of the radiated frequency for dipole radiators, so for a Quad ESL 63 at 0. 66 meters wide this occurs at around 129 Hz so is comparable to many box speakers.

Disadvantages include the risk of surgery, which is often self-performed, and increased susceptibility to sexually transmitted infections ( STIs ).

Disadvantages include its inability to provide data regarding right-sided heart pressures, or mixed venous oxygen saturation.

Disadvantages include high transfer costs, the possibility of encountering local government restrictions, and possibly creating a problem of adaptability to foreign environments.

Disadvantages of emulsion polymerization include:

Disadvantages when compared with other types include: Mercury switches have a relatively slow operating rate due to the inertia of the mercury drop, so they are not used when many operating cycles are required per second.

Disadvantages include susceptibility to rot and high space requirements for the straw itself.

Disadvantages include:

Disadvantages include high bearing loads, inaccessibility, and design complexity.

Disadvantages include ' floating ' where the user looks like a marionette on strings, lower positional accuracy and positional drift which can compound over time.

Disadvantages of most enzymatic drain cleaners include longer cleaning times compared to most other drain cleaners.

Disadvantages include low phase-change enthalpy, low thermal conductivity, and flammability.

Disadvantages include high energy requirements of the cryocooler and mechanical vibrations as e. g. intrinsic to the pulse tube refrigerator.

Disadvantages are, for example, that only a limited number of bands can be accommodated because the time scale of the chromatogram is short, and, in general, there has to be a 10 % difference in molecular mass to have a good resolution

Disadvantages include lack of margin control, tissue necrosis, over or under treatment of the tumor, and long recovery time.

Disadvantages of the Haldex Traction system include: the vehicle has inherent front-wheel drive handling characteristics ( as when engine braking, load is only applied on the front wheels, and due to the reactive nature of the Haldex system and slight lag time in the redistribution of engine power ), and the Haldex LSC unit also requires additional maintenance, in the form of an oil and filter change every ( whereas the Torsen is generally considered to be maintenance-free ).

Disadvantages of this four wheel drive system are related to actuation time of the viscous coupling.

Disadvantages include the inability to tweak details which may affect performance or the desired output, and the time and cost of acquiring, learning, and configuring the library.

Disadvantages of this threshold are: ( 1 ) that it can encourage insureds ( and their medical providers ) to exaggerate medical costs through over-utilization, and ( 2 ) that, unless indexed, it can become ineffective over time because of inflationary effects on medical costs.

Disadvantages of endovascular repair include a requirement for more frequent ongoing hospital reviews, and a higher chance of further procedures being required.

Disadvantages of this approach include the toxicity of cobra venom factor, and most importantly these treatments would deprive the individual of a functional complement system.

Disadvantages of these included the need for regular visits to remove cash, and risk of theft of the cash in the meter.

Disadvantages include the technically challenging nature of these procedures which replace portions of a structure only 500 microns thick, and reduced optical performance of the donor / recipient interface compared to full thickness keratoplasty.

Disadvantages of this set-up included an inability to back the vessel astern, limited maneuverability and the deafening noise of the engines which would have made voice commands problematic.

Disadvantages of single wire operation such as crosstalk and hum from nearby AC power wires had already led to the use of twisted pairs and, for long distance telephones, four-wire circuits.

Disadvantages are that the system triggers demotivation of inferiors, who know that their ideas to innovative approaches might not be welcome just because of their position, and that the decision-makers cannot make use of the full range of expertise which their inferiors will have collected.

This particularly in view that castration has a history, up to the modern age, of therapeutic use ; according to Victor T. Cheney, in his Castration: Advantages and Disadvantages ( Authorhouse, Dec. 2003 ),

Disadvantages 3, 4, and 5 are also applicable to some 12 volt DC adaptors made for cigarette lighter receptacle use in automobiles, or connections to a plain 12 volt lead-acid battery.

Disadvantages ( from the modern perspective ) are that space is used for a whole year, some nutrients might be leached due to exposure to rainfall, and disease producing organisms and insects may not be adequately controlled.

Disadvantages are that sparse files may become fragmented ; file system free space reports may be misleading ; filling up file systems containing sparse files can have unexpected effects ( such as disk-full or quota-exceeded errors when merely overwriting an existing portion of a file that happened to have been sparse ); and copying a sparse file with a program that does not explicitly support them may copy the entire, uncompressed size of the file, including the zero sections which are not allocated on disk — losing the benefits of the sparse property in the file.