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# Exclusion of metabolic, gastrointestinal or central nervous system structural or biochemical disease e. g. individuals with specific physical causes ( e. g. intestinal malrotation )
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# and Exclusion
# Exclusion of other autoimmune diseases, hypercoagulable states, and diabetes mellitus by laboratory tests.
* Plaque: A plaque showing the prohibited area as defined in Exclusion Order # 26 for those of Japanese ancestry, both alien and non-alien.
# and metabolic
# Chemical stability: CSF flows throughout the inner ventricular system in the brain and is absorbed back into the bloodstream, rinsing the metabolic waste from the central nervous system through the blood – brain barrier.
# Alteration of metabolic pathway: e. g., some sulfonamide-resistant bacteria do not require para-aminobenzoic acid ( PABA ), an important precursor for the synthesis of folic acid and nucleic acids in bacteria inhibited by sulfonamides.
# endogenous damage such as attack by reactive oxygen species produced from normal metabolic byproducts ( spontaneous mutation ), especially the process of oxidative deamination
# and gastrointestinal
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