Petty Officers and Chief Petty Officers are referred to by a combination of rate and rating: for example, a Petty Officer Second Class with the rating of Gunner's Mate is referred to and addressed as " Gunner's Mate Second Class ," abbreviated and sometimes spoken GM2 ; similarly a Chief Petty Officer with the rating of Quartermaster is referred to as a Chief Quartermaster ( QMC ).

As a result, progressive damage caused by the resulting buildup of GM2 ganglioside leads to the destruction of nerve cells, causing the signs and symptoms associated with Sandhoff disease.

Here's a quick overview of the GM2 changes in comparison to GM / GS:

GM2 is the basis of the instrument selection mechanism in Scalable Polyphony MIDI ( SP-MIDI ), a MIDI variant for low power devices that allows the device's polyphony to scale according to its processing power.

** GM2 System On SysEx message

The MIDI sequences are typically General MIDI and GM2 standard, but sequences that use proprietary MIDI standards like Roland GS and Yamaha XG are also available on the site.

Tay – Sachs disease ( also known as GM2 gangliosidosis or hexosaminidase A deficiency ) is an autosomal recessive genetic disorder.

Two of them are subunits of hexosaminidase A ; the third is a small glycolipid transport protein, the GM2 activator protein ( GM2A ), which acts as a substrate-specific cofactor for the enzyme.

By the end of 1979, researchers had identified three variant forms of GM2 gangliosidosis, including Sandhoff disease and the AB variant of GM2-gangliosidosis, accounting for false negatives in carrier testing.

The biochemical mechanism for this disease in the Jacob sheep is virtually identical to that in humans, wherein diminished activity of hexosaminidase A results in increased concentrations of GM2 ganglioside in the affected animal.

Other experimental methods being researched involve substrate reduction therapy, which attempts to use alternative enzymes to increase the brain's catabolism of GM2 gangliosides to a point where residual degradative activity is sufficient to prevent substrate accumulation.

One experiment has demonstrated that using the enzyme sialidase allows the genetic defect to be effectively bypassed, and as a consequence, GM2 gangliosides are metabolized so that their levels become almost inconsequential.

This drug is a reversible inhibitor of the enzyme glucosylceramide synthase, which catalyzes the first step in synthesizing glucose-based glycosphingolipids like GM2 ganglioside.

DNA tests are available for three genetic diseases or conditions which have been found in Burmese cats: the Burmese Head Defect, GM2 Gangliosidosis and Hypokalaemia.

Her first theatrical feature film, Rihanna appeared as Petty Officer ( GM2 ) Cora Raikes in the 2012 film Battleship from director Peter Berg.

Furthermore Batten, at least for some time, insisted that the condition that he described was distinctly different from Tay-Sachs disease, the prototype of a neuronal lysosomal disorder now identified as GM2 gangliosidosis type A.

This swelling is shown, for instance, in Tay-Sachs, a GM2 accumulation due to defective Beta-Hexosaminidase.

These catabolic enzymes are needed to degrade the neuronal membrane components, ganglioside GM2, its derivative GA2, the glycolipid globoside in visceral tissues, and some oligosaccharides.

Besides the neuronal storage of GM2, the storage of GA2 was much more pronounced, and different from all cases of Tay-Sachs disease studied so far, globoside accumulated in the visceral organs and, most importantly, hexosaminidase activity was almost completely absent.

This is caused by a slow deterioration of the muscles in the child ’ s body from the buildup of GM2 gangliosides.

In particular, beta-hexosaminidase A breaks down a fatty compound called GM2 ganglioside.

Mutations in the HEXB gene disrupt the activity of these enzymes, preventing the breakdown of GM2 ganglioside and other molecules.

The three diseases are classified together as the GM2 gangliosidoses, because each disease represents a distinct molecular point of failure in the activation of the same enzyme, beta-hexosaminidase.

AB variant is caused by a failure in the gene that makes an enzyme cofactor for beta-hexosaminidase, called the GM2 activator.

It was eventually determined that GM2 gangliosidosis could be caused by mutations on three distinct genes, one of which was an activator protein.

The GM2A gene provides instructions for making a protein called the GM2 activator.

This protein is required for the normal function of beta-hexosaminidase A, a critical enzyme in the nervous system that breaks down a lipid called GM2 ganglioside.

The Segway notices, as it balances, the change in its center of mass, and first establishes and then maintains a corresponding speed, forward or backward.

Application programmers can still use any addressing mode: all applications, regardless of their addressing mode ( s ), can coexist without modification, and IBM maintains an unwavering commitment to tri-modal backward compatibility.

* Windows XP 64-bit Edition, is a version for Intel's Itanium line of processors ; maintains 32-bit compatibility solely through a software emulator.

MicroXwin is not a full-fledged replacement for X but maintains binary compatibility with standard X clients while providing better performance and significantly lower memory overhead by a different architecture of design that directly implements the system as a kernel module.

Ham-Friendly ALE technique is also known as 2. 5G ALE, because it maintains 2G ALE compatibility while employing some of the adaptive channel management features of 3G ALE, but without the accurate GPS time synchronization of 3G ALE.

The Apple IIe maintains a high degree of backwards compatibility with the previous two Apple II models, allowing most hardware and software from those systems to be used.

As a rule, the host adapter appears as SCSI ID 7, which gives it the highest priority on the SCSI bus ( priority descends as the SCSI ID descends ; on a 16-bit or " wide " bus, ID 8 has the lowest priority, a feature that maintains compatibility with the priority scheme of the 8-bit or " narrow " bus ).

The VCL framework maintains a high level of source compatibility between versions which simplifies adapting existing source code to a newer Delphi version.

IS-54 maintains compatibility with Advanced Mobile Phone System ( AMPS ) in many ways.

GB18030 can be considered a Unicode Transformation Format ( i. e. an encoding of all Unicode code points ) that maintains compatibility with a legacy character set.

GB18030 also maintains compatibility with Windows Codepage 936, sometimes known as GBK, which is Microsoft's extended version of GB2312, with the exception of the euro sign which is given a single byte code of 0x80 in Microsoft's later versions of GBK and a two byte code of A2 E3 in GB18030.

The API is similar to the Internet Explorer ActiveX control so it maintains a high degree of compatibility.

It maintains 100 % database compatibility with Scid.

A third compatibility mode known as either " almost standards mode " or " strict mode " which maintains the " traditional " vertical sizing of table cells according to the CSS2 specification, has been implemented in these browsers: Safari, Opera 7. 5 ( and later ), all Gecko-based browsers since 1. 0. 1 ( such as Firefox ) and Internet Explorer 8.

The problem with the XML declaration was fixed in version 7 of Internet Explorer, in which the XML prolog is simply ignored .< ref > However, for maximum compatibility with existing and older web browsers, the World Wide Web Consortium, which maintains the XHTML specification, suggests that authors of XHTML documents could consider omitting the XML declaration.