The success of his discovery soon spread around Europe and for example was used en masse in the Spanish Balmis Expedition, a three year long mission to the Americas, Philippines, Macao, China, and Saint Helena Island led by Dr. Francisco Javier de Balmis with the aim of giving thousands the smallpox vaccine.

However, both the location of the island and its name were quoted in a Dutch book in 1508, which described a 1505 Portuguese expedition led by Francisco de Almeida from the East Indies: " n the twenty-first day of July we saw land, and it was an island lyng six hundred and fifty miles from the Cape, and called Saint Helena, howbeit we could not land there.

This precursor to the effects of the Suez Canal ( 1869 ), coupled with the advent of steam shipping that was not reliant on trade winds led to a gradual reduction in the number of ships calling at St Helena and to a decline in its strategic importance to Britain and economic fortunes.

* Sweeney Todd, ( 2007 ) a movie adaptation of the stage work, made with Sondheim's participation and approval, was directed by Tim Burton, featuring a largely nonmusical cast led by Johnny Depp and Helena Bonham Carter.

Helena gave Lucky instructions which led him to her secret lab underneath General Hospital.

Other notable characters of the first season were Helena, a prosecutor whose lack of ability often led to comic relief moments ; Claudia, Richard's sardonic barrister ; Giles, the amiable old barrister contracted to MDA ; Dr Vince Phillips, a doctor on the MDA board whose desire to take over led to a legal battle ; and Dr Mark Matthews, the head of the MDA board.

Nicholas and Helena Roerich led a 1924-1928 expedition aimed at Shambhala.

The column was led by Farenholt, Duncan, and Laffey, and followed by San Francisco, Boise, Salt Lake City, and Helena.

The Justice League of Amazons was formed by Wonder Woman and she led the team consisting of Supergirl ( Linda Danvers ), Huntress ( Helena Bertinelli ), Big Barda, Zatanna, Power Girl, and Black Orchid.

An opportunity arises when he meets Helena, who is married to Pavel Zemanek, the friend who led the efforts to purge Ludvik from the party.

In July, this division ( now led by Frederick Salomon ) fought at the Battle of Helena as part of the District of Eastern Arkansas under Benjamin M. Prentiss.

During all these historical endeavors, Constantine, son of Milosch and Helena, brother of the boy Michael who had become Ballaban Badera, was a soldier under the command of George Kastriota fighting against the Ottoman Armies led by his brother.

Every May, Peñaranda residents stage a musical drama called " Araquio ", a re-enactment of Christians ' quest led by Queen Helena and King Constantine for the Holy Cross where Jesus Christ was nailed.

It is the fictional story of the making of a silver chalice to hold the Holy Grail ( itself here conflated with the Holy Chalice ) and includes 1st century biblical and historical figures: Luke, Joseph of Arimathea, Simon Magus and his companion Helena, and the apostle Peter.

Helena forced Lucky to inject Luke with a virus that would make Luke go crazy and render him useless as an opponent to the Cassadines.

When Luke showed up alive at the apartment, Lucky asked Luke to help him fight Helena.

However, Lucky later showed up on the Cassadine yacht to accuse Helena of killing Chloe, Luke, and Elizabeth.

At the memorial, Lucky watched as Helena cursed everyone in the room for Nikolas's death and then Luke got up to stop her.

Taylor appeared in five episodes as Helena Cassadine, the widow of Mikkos Cassadine, whom Luke and Laura killed.

When mother and daughter are reunited, Luke conspires with Tom Hardy ( Matthew Ashford ) to fake their deaths to keep them safe from Helena.

Luke and Laura traveled to many places in their past as they followed the clues Helena dropped along the way.

Helena had made Lucky believe that his parents were behind the whole kidnapping, shocking both Luke and Laura.

Luke promised Laura that he would undo whatever Helena did to Lucky.

Just as Luke was starting to recover, Laura and Nikolas went to confront Helena in her underground lab.

In hot pursuit of his favorite nemesis, Luke discovered that Helena had hid out at Wyndemere and that Nikolas gave Helena money and let her go in order to protect Gia.

Soon after, Luke discovered that Helena had placed a double in her place in prison and he tracked her to a convent.

In an attempt to avenge her mother ’ s death, she teams up with Luke to kill Helena, and mistakenly pushes Katherine off a parapet instead.

Helena gave Lucky a diamond ring ( the same ring that Stavros gave to Laura when they were married ) to give to Elizabeth and instructed him to propose to her.

Stavros ' evil mother Helena hated Laura.

Helena didn't help much either when she told Laura that it was her fault that Lucky was dead, and Laura suffered a nervous breakdown.

Helena left hints that Katherine wasn't really pregnant and Laura confronted Katherine.

However, Stefan and Laura became suspicious that Helena had actually killed Katherine and grew quite close to each other, to the point of making love, as they gathered evidence to prove their theory.

Jennifer Chambers Lynch ( born April 7, 1968 ) is an American film director and screenwriter, best known for writing the book, The Secret Diary of Laura Palmer ; Lynch was also Hollywood's youngest female writer and director, a claim that remains in 2012, ( for her 1993 feature film, Boxing Helena ).

Novocaine is a 2001 black comedy thriller film written and directed by David Atkins and starring Steve Martin, Helena Bonham Carter, Laura Dern, Lynne Thigpen and Elias Koteas.

* Chapel of the Invention of the Holy Cross-another set of 22 stairs from the Chapel of Saint Helena leads down to the Roman Catholic Chapel of the Invention of the Holy Cross believed to be the place where the True Cross was found.

Since it is known that Helena ordered the Temple of Venus to the west of the Temple Mount to be torn down to construct the Church of the Holy Sepulchre, presumably she also ordered the Temple of Jupiter on the Temple Mount to be torn down to construct the Church of St. Cyrus and St. John.

Because British royal rule is not salic ( meaning passed down along the male line, but rather, through immediate family ), following the deaths of these people each of Queen Victoria's ' untitled ' daughters would assume the throne in turn ; Princess Louise, Princess Helena, and finally Princess Beatrice.

Alfonso sat down between Queen Alexandra and Princess Helena, King Edward's sister.

Helena supposedly cast one nail into the sea to calm a storm, while another was incorporated into Constantine's helmet, another fitted to the head of a statue of the Emperor, and a fourth melted down and molded into a bit for Constantine's horse.

Las Cases and his son accompanied the ex-emperor to Saint Helena and acted informally but very assiduously as his secretary, taking down numerous notes of his conversations which thereafter took form in the famous Mémorial de Ste Hélène.

Winds exceeding 100 mph sheared off one of the wings of the plane, causing the aircraft to go down in Wolf Creek Canyon north of Helena.

Near the end, the dead body of Helena ( played by actress and dancer Tracy Phillips ) rises and dances down the nave representing crossing over into the afterlife.

Helena Devereux would serve as Director until she stepped down in 1957.

Though he had initially rejected both his fathers, Phillip, upon learning Justin was flying out of town, tracked him down at the airport and not only forgave him for keeping his parentage a secret, but also gave his blessing for Justin and Helena to marry.