The model which Conan Doyle himself mentions ( through Sherlock Holmes ) in The Valley of Fear is the London arch-criminal of the 18th century, Jonathan Wild.

He mentions this when seeking to compare Moriarty to a real-world character that Inspector Alec MacDonald might know, but it is in vain as MacDonald is not so well read as Holmes.

* In the videogame Portal 2, Wheatley mentions Holmes and Moriarty as a reference the way Chell ( Holmes ) pursuits Wheatley ( Moriarty ) with the purpose of finishing him off before he kills her.

In " The Five Orange Pips ", Holmes mentions that he has been beaten four times, thrice by a man and once by a woman.

Also, in " A Case of Identity ", Watson mentions that Adler is the only person he has ever known to have beaten Holmes.

Interestingly, Sherlock Holmes also mentions " Basil " as one of his aliases in the Arthur Conan Doyle story " The Adventure of Black Peter ".

In " The Adventure of Black Peter ", an original Arthur Conan Doyle Holmes story from 1904, Watson mentions that his companion recently arrested " Wilson, the notorious canary-trainer, which removed a plague-spot from the East-End of London "; this Wilson is not related to the titular character of Meyer's novel.

One of Boston's most enduring nicknames, " The Hub of the Universe ", is from a remark by Oliver Wendell Holmes from his 1858 book The Autocrat of the Breakfast-Table in which he mentions the State House ( emphasis added ):

* The Sherlock Holmes story A Scandal in Bohemia mentions a fictional " King of Scandinavia " whose daughter is about to marry the ( also fictional ) King of Bohemia, a major protagonist in the story.

* Holmes mentions his brother, Mycroft, when preparing to leave the school.

At the start of the story, Watson mentions two unrecorded cases that Holmes investigated around the same time as this story:

In " The Adventure of the Sussex Vampire ", Holmes mentions to Watson the case of the Giant Rat of Sumatra, referring to it as " a story for which the world is not yet prepared ".

In The Adventure of the Illustrious Client, Holmes mentions Moran as being still alive.

* In the 1975 novel Sherlock Holmes's War of the Worlds, Holmes mentions that Professor Challenger helped solve the case of the giant rat, although the actual name of the case is not stated, nor what was involved.

Watson's insight is verified by the mysterious link between Holmes and his arch-opponent, Dr. Moriarty.

The first series of Sherlock Holmes adventures ends with Holmes and Moriarty grappling together on the edge of a cliff.

Linked to Holmes even in death, Moriarty represents the alter-ego of the great detective, the image of what our hero might have become were he not a public servant.

The characters of Sherlock Holmes and Moriarty had in reality been a set of prototype programs written for the Analytical Engine.

An early famous example in popular culture is the return of Sherlock Holmes: writer Arthur Conan Doyle killed off the popular character in an encounter with his foe Professor Moriarty, only to bring Holmes back, due in large part to audience response.

When Sir Arthur Conan Doyle killed off his most-beloved character Sherlock Holmes by plunging him to his death over the Reichenbach Falls with his arch nemesis Professor Moriarty, the public's demand for Holmes was so great that Doyle was compelled to bring him back to life in a subsequent story, where he details that Holmes had merely faked his death.

* May 4 – Professor James Moriarty, fictional criminal mastermind of Sir Arthur Conan Doyle's Sherlock Holmes short story The Final Problem ( b. unknown )

Having eventually retrieved the cavorite, the League delivers it into the hands of their employer — none other than Professor Moriarty ( arch nemesis of Sherlock Holmes ), who plans to use it in an airship of his own, with which he will bomb his adversary's Limehouse lair flat, taking large parts of London and the League itself with it.

Mycroft Holmes replaces Moriarty as the League's employer, and the extraordinary individuals are tasked to remain in service to the Crown, awaiting England's call.

Professor James Moriarty is the archenemy of Sherlock Holmes, a fictional detective created by Sir Arthur Conan Doyle.

Moriarty is a criminal mastermind whom Holmes describes as the " Napoleon of crime ".

The character of Moriarty as Holmes's greatest enemy was introduced primarily as a narrative device to enable Conan Doyle to kill off Sherlock Holmes, and only featured directly in two of the Sherlock Holmes stories.

The criminal mastermind follows, and the pursuit ends on top of the Reichenbach Falls, during which both Holmes and Moriarty apparently fall to their deaths while locked in mortal combat.

Holmes, by his own account, was originally led to Moriarty by the suggestion that many of the crimes he perceived were not the spontaneous work of random criminals but the machinations of a vast and subtle criminal ring.

Moriarty plays a direct role in only one other of Doyle's Holmes stories, The Valley of Fear, which was set before " The Final Problem " but published afterwards.

Moriarty does not meet Holmes in this story.

In an episode where Moriarty is interviewed by a policeman, a painting by Jean-Baptiste Greuze is described as hanging on the wall ; Holmes remarks on another work by the same painter to show it could not have been purchased on a professor's salary.

More obliquely, a 1908 mystery by Doyle that was named " The Lost Special " features a criminal genius who could be Moriarty and a detective who could be Holmes, although neither is mentioned by name.

Viktor Yevgrafov as Professor Moriarty in Igor Maslennikov's The Adventures of Sherlock Holmes and Dr. Watson | TV series.

For example, one early " Swedish Erotica " brochure from 1973 has five loops featuring Holmes, each with a different name.

In February 1986, five or six months after testing negative for the virus, Holmes was diagnosed as HIV positive after a second HIV test.

During the last five months of his life, Holmes remained in the VA hospital on Sepulveda Boulevard in Los Angeles.

On September 10, 1983, Holmes successfully defended the WBC title for the sixteenth time, knocking out Scott Frank in five rounds.

Darien has five elementary schools: Hindley School, Holmes School, Ox Ridge School, Royle School, and Tokeneke School.

The plan to end tuition for students who pledged five years of public interest work was cut in favor of more flexible incentives, and the new Holmes Fellowship was introduced to provide funding for students engaged in public interest work.

He won the Silver Goblets & Nickalls ' Challenge Cup for coxless pairs seven times ( twice with Andy Holmes, once with Simon Berrisford and four times with Matthew Pinsent ), the Stewards ' Challenge Cup for coxless fours five times, the Diamond Challenge Sculls twice, the Double Sculls Challenge Cup once ( with Eric Sims ) and the Queen Mother Challenge Cup for quadruple sculls once.

Bilbo disliked Holmes, and spoke against him for five hours ; he was the only senator to vote against Holmes ' confirmation.

The skit was titled The Frightful Predicament of Sherlock Holmes, and there were but five characters in the entire skit: Holmes, Billy the page boy ( played by Henry McArdle ), the madwoman Gwendolyn Cobb ( who had nearly all of the dialogue and was played by Ethel Barrymore ), and the two " valuable assistants " who come to take the madwoman away.

Holmes and Cooney fought closely from rounds five to eight, trading punches in mid-ring.

On 3 May 2002 Lincoln successfully petitioned to go into administration but the financial crisis would leave the first team squad bereft of players as the day saw five senior players – Jason Barnett, Grant Brown, David Cameron, Steve Holmes and Justin Walker – released at the end of their contracts with a sixth, Lee Thorpe, departing for Leyton Orient.

Holmes was a compromise candidate after five Republicans refused to support Rep. Leo Daughtry.

During the rest of the year, Holmes published only five more poems.

Holmes then sends five orange pips to the captain of The Lone Star and he sent a telegram to the police to Savannah that the Captain and two mates are wanted for murder.

After starting two games and averaging over five yards per carry for the second straight season as a sophomore, Holmes received more significant playing time as a junior.

It would have been written by former script editor Robert Holmes and would have featured the Cybermen and their kidnapping of the five incarnations of the Doctor ; in their attempt to extract Time Lord DNA to turn themselves into " Cyberlords ", the twist being that the First Doctor and Susan would actually be android impostors ( the former being the " Sixth Doctor " of the title ) and the Second Doctor would have saved the day.

Daniel Henry Holmes Ingalls, Jr. is a pioneer of object-oriented computer programming and the principal architect, designer and implementor of five generations of Smalltalk environments.

Suddenly, however, five days after the murder, Holmes is astonished to read in the newspaper that Baynes has arrested someone, Garcia ’ s cook, the brutish fellow who had given the constable such a start.

The Radio Four panel game they wrote with Jon Holmes and Tony Roche, The 99p Challenge, ran for five series from 2000 .< ref >

Robert Holmes was born on May 11, 1909, in Canisteo, New York, to a family with five other siblings.

" Andrea Holmes of AOL ranked " Behind These Hazel Eyes " at number five in her list of " Top Wedding Music Videos: 15 Clips for the Big ' I Do '.

Holmes left the Michigan Rangers as a rearguard while his main body retreated five miles to the Twenty Mile Creek.