However, another randomized controlled trial found primary closure led to 35 % failing to heal primarily and primary closure longer median number of days to closure ( 8. 9 versus 7. 8 ).

However, in 1975 the closure of a major factory cut the celebration short and new challenges were created overnight.

However, with the use of cre-lox technology, a caspase 8 knock-out has been created that exhibits an increase in peripheral T cells, an impaired T cell response, and a defect in neural tube closure.

However, such factories are unlikely to achieve " full closure " until the cost and flexibility of automated machinery comes close to that of human labour and the manufacture of spare parts and other components locally becomes more economical than transporting them from elsewhere.

However: intake valve closure ( sealing the cylinder ) always takes place after BDC, which may cause some of the intake charge to be compressed backwards out of the cylinder by the rising piston at very low speeds ; only the percentage of the stroke after intake valve closure is compressed.

However, recent work has shown that for languages which make this distinction, all clicks have a uvular, or even pharyngeal, rear closure, and that the clicks explicitly described as uvular are in fact clusters / contours of a click plus a pulmonic or ejective component, in which the cluster / contour has two release bursts, the forward ( click ) and then the rearward ( uvular ) component.

However, exactly 100 years after Braid introduced the method, another expert could still state: " It can be safely stated that nine out of ten hypnotic techniques call for reclining posture, muscular relaxation, and optical fixation followed by eye closure.

However, the title was said to be in production without the approval of Nintendo, and Factor 5 cancelled multiple projects following the closure of its American branch in early 2009.

However, in Germany this depression was virtually a continuation of an economic morass that had blighted the country since the end of World War I, partly the result of the war reparations the country had been made to pay, and this morass had brought about the closure and demolition of the Grand Hotel Belle Vue, on the corner of Bellevuestraße and Königgrätzer Straße, thus enabling one revolutionary new building to struggle through to reality despite considerable financial odds.

However with the closure of Locomotive Games the game has been abandoned, although several models and a full-length trailer were released to the public upon the closure of the studio.

However, inaccuracy, the missing closure of a pumice quarry, and the oncoming building of some four harbours by the shore of the sole town of Lipari

However, the past twenty years have witnessed the widespread closure of these separate programmes in the UK and the integration of the discipline into either history or economics departments.

However, one of the show's charms is to make much out of everyday, small concerns, such as the possible closure of the village shop, the loss and rediscovery of a pair of spectacles, competitive marmalade-making, or nonsense such as a ' spile troshing ' competition, rather than the large-scale and improbable events that form the plots of many soap operas.

However, because of the predicted thousand years until the rise of the next Empire ( of which only a few hundred had elapsed ), the series lacked a sense of closure.

However, in the Third Age, particularly after the closure of Moria, they grow mistrustful of Elves, though in later times cordial relations are established with the Elves of Mirkwood and the Men of Dale.

However after the revolt of the seven northern provinces ( 1568 ), the Sack of Antwerp ( 1576 ), the Fall of Antwerp ( 1584-1585 ), and the resulting closure of the Scheldt river to navigation, a large number of people from the southern provinces emigrated north to the new republic.

However, reorganisation of lines and closure of stations left Bermondsey's transport links with the rest of London poorer in the late Twentieth Century.

However, when Interstate 40 bypassed the small village to the north in May, 1970 and received only one exit from the freeway, the local economy went into a decline due to the bypass and the concurrent closure of nearby Clinton-Sherman Air Force base at Burns Flat, leading most of those businesses to shut down.

However, in his controversial report, Dr Beeching declared that the Whitby-Pickering line was uneconomic and listed it for closure, which took place in 1965.

However, this story was never finished due to the closure of Dreamwave.

However, expressing these properties as axioms requires use of second-order logic.

However, to go further requires new capacities that combine the clarity of intellectual thought with the imagination, and beyond this with consciously achieved inspiration and intuitive insights.

However travel through very remote areas, on isolated tracks, requires planning and a suitable, reliable vehicle ( usually a four-wheel drive ).

However the IRS now requires barter exchanges to be reported as per the Tax Equity and Fiscal Responsibility Act of 1982.

However the Bill of Rights of 1689 requires Parliamentary consent for the Crown to maintain a standing army in peacetime.

However, the discrete and separate nature of the molecular concept usually requires that molecular ions be present only in well-separated form, such as a directed beam in a vacuum in a mass spectrograph.

However, its practical limitations — it requires the sun to shine and does not work at all during the night — encouraged the use of other techniques for measuring time.

However, firing a pistol effectively at any significant range requires good training, since the absence of a buttstock makes precise ranged aim difficult.

However, this tends to be complicated by the fact that this requires finding the roots of a high degree polynomial, and there can be multiple roots that represent local maxima.

However, U. S. law permits " blended " whisky to contain up to 80 % un-aged grain neutral spirits ( with an age statement on the label that refers only to the " straight " part of the blend ), while Canadian law requires that all of the spirits in a Canadian whisky be aged for at least three years.

However a high index of suspicion is appropriate, since diarrhea and bloating are also symptoms of typhlitis, a very serious and potentially life-threatening medical emergency which requires immediate treatment.

However, attempts made in closed-door sessions at the Fourth Plenary Session of the 17th Communist Party of China's Central Committee in September 2009 to grapple with these problems produced inconclusive results, although a directive which requires disclosure of investments and property holdings by party and governmental officials was passed.

However, existing law requires judicial approval of all class action settlements, and in most cases class members are given a chance to opt out of class settlement, though class members, despite opt-out notices, may be unaware of their right to opt out because they did not receive the notice, did not read it, or did not understand it.

However, often, the required output signal is another analog output signal, which requires a digital-to-analog converter ( DAC ).

However this behaviour is application-specific, and requires that the application maintains a catalog of known URNs to resolve them into the notations that have been parsed in a standard SGML or XML parser.

However, DSN tracking requires many skilled operators, and the DSN is overburdened by its use as a communications network.

However, technology transfer requires knowledgeable managers and engineers who are able to operate new machines or production practices borrowed from the leader in order to close the gap through imitation.

However, electrolysis requires an external source of electrical energy to induce a chemical reaction, and this process takes place in a compartment called an electrolytic cell.

However, the church asserts that Apostolic Succession also requires Apostolic Faith, and bishops without Apostolic Faith, who are in heresy, forfeit their claim to Apostolic Succession.

However, technology maturity requires a further understanding of the technology itself.

However, if the decomposition into given above is possible, then requires storing 4 values, requires storing values, and again requires storing just 4 values.

However, due to lack of intermediate elements, this process requires three helium nuclei striking each other nearly simultaneously ( see triple alpha process ).

However, the inquest should set out as many of the facts as the public interest requires.