However the last enzyme is absent in humans, explaining the disease known as gout, caused by the accumulation of uric acid.

However when a ' a enters the ocean it forms a littoral cone, a small cone-shaped accumulation of tuffaceous debris formed when the blocky a ' a lava enters the water and explodes from built-up steam.

However, it is now known that this is due to an overexpression and accumulation of the lysosomal endogenous beta-galactosidase, and its expression is not required for senescence.

However, this method is not yet ready for clinical trials, due to the accumulation of the nanospheres in surrounding healthy tissue.

However, some believe that in the long-term society as a whole ( including the descendants of those that experienced short-term hardship ) enjoys a rise in overall quality of life due to the accumulation of innovation-for example, 90 % of Americans were farmers in 1790, while 2. 6 % of Americans were farmers in 1990.

However, the loss of state revenues created a long term revenue shortfall that could not be easily reversed and subsequent governors were unable to offset the huge cumulative revenue losses as well as interest accumulation.

However, freezing rain is accompanied by a temperature inversion aloft, meaning that aircraft actually need to climb to move into warmer air — a potentially difficult and dangerous task with even a small amount of ice accumulation.

However, his accumulation of power came at the expense of the independence of the judiciary and the traditional powers and privileges of Malaysia's royalty.

However, an accumulation of evidence and a reassessment of existing material has caused opinions on Nabonidus and the events that happened during his reign to alter significantly in recent decades.

However, accumulation of carbon dioxide ( described above ) would remain the limiting factor.

However, as the peat soil is gradually elevated by the accumulation of organic matter, and the fertility of the site improves, Balsam Fir and Eastern Arborvitae Thuja occidentalis will eventually replace Black Spruce and Tamarack.

However switching off these enzymes can also cause abnormal accumulation of glycogen and phospholipids in lysosomes, causing a toxic myopathy.

However, even though annual kelp production is higher, the productivity of individual plants is lower due to lower biomass accumulation of fucoid algae.

However, he accepted the concept of a world mind, which according to him contained the accumulation of the totality of man's knowledge and experience.

However, the extent of inflammatory response varies widely and does not always correlate with degree of fat accumulation.

However, there seems to be a proportional relationship between the accumulation of OMgp and axon diameter.

However, this spending quickly led to the accumulation of debt, and the club folded.

However, in the course of time the accumulation of material possessions and the limitations placed on the number of members admitted ( for at one time there were only about 170 in the 94 monasteries ) led to laxity and serious abuses.

However, the accumulation of hypotheses to rescue the stationary aether concept was considered to be very artificial.

However, in yet another twist, Simon Jones and Harmison fought back with some streaky accumulation, pairing up for 33-the fifth-highest partnership of the game thus far-to reduce Australia's lead to 35 runs.

However, this was likely an anomaly, as the current highway is generally closed from November through May due to snow accumulation.

However, around the Mediterranean they include also a dozen woody shrubs 1m-3m tall, e. g. in northern Africa ( Zilla spinosa and Ptilotrichum spinosum ), in the Dalmatian islands ( Dendralyssum and Cramboxylon ), and chiefly in Canarias with some woody cruciferous genera: Dendrosinapis, Descurainia, Parolinia, Stanleya, etc ..

The Indians all know we cannot be a Match for them in the midst of an extensive woody Country ... from whence I infer that if we are determined to possess Our Posts, Trade & ca securely, it cannot be done for a Century by any other means than that of purchasing the favour of the numerous Indian inhabitants. With the proclamation, “ the British were trying to convince Native people that there was nothing to fear from the colonists, while at the same time trying to increase political and economic power relative to First Nations and other European powers .” However, the Royal Proclamation along with the subsequent Treaty of Niagara, provide for an argument that “ discredits the claims of the Crown to exercise sovereignty over First Nations ” and affirms Aboriginal “ powers of self-determination in, among other things, allocating lands .” Further so, the Royal Proclamation outlined a policy in which to protect and extinguish Aboriginal rights and in doing so, recognized these rights existed.

However, because of overgrazing, land clearing, and the suppression of wildfires, these native grasses have been mostly replaced by invasive weeds and tough, woody trees, including: Texas live oak, Texas red oak, red juniper ( red cedar ), and mesquite.

However, it was shown that subfamily Nivenioideae as traditionally defined is paraphyletic: Crocoideae was consistently found nested within it, sister to the core Nivenioideae ( the woody genera Klattia, Nivenia, and Witsenia ).

However, woody plants not only belong to many different plant families, but these families may be made up of both woody and non-woody members.

However, in the eastern Cascade Range of Washington, the average volume of coarse woody debris in small nest plots was similar to that in random plots within nest stands.

However, nest sites are usually characterized by dense tall residual vegetation ( last year ’ s growth ) with the presence of woody vegetation either at the nest site or nearby ( Manske and Barker 1987 ; Prose et al.

However, sheoak " cones " are actually a woody fruit.

However, S. putorius usually enjoy staying in rocky and woody habitats that have copious amounts of vegetation.

However during the intense Alaskan winters, they will also feed on woody vegetation and lichen.

However research in Washington state found that the average summer smolt production per beaver dam ranges from 527 to 1, 174 fish, whereas the summer smolt production from a pool formed by instream large woody debris is about 6 – 15 individuals, suggesting that re-establishment of beaver populations would be 80 times more effective.

However, these woody fruits also provide protection of the seeds from fire.

However, Kusche's research showed that the unclassified version of the Air Force investigation report stated that the debris field defining the second " crash site " was examined by a search and rescue ship, and found to be a mass of seaweed and driftwood tangled in an old buoy.

However, distinctive karst surface features may be completely absent where the soluble rock is mantled, such as by glacial debris, or confined by one or more superimposed non-soluble rock strata.

However, it is disadvantaged by it being necessary for the base metal ( or ceramic ) having to undergo some wear first to generate sufficient oxide debris.

However, development of the Shuttle was delayed, and Skylab reentered Earth's atmosphere and disintegrated in 1979, with debris striking portions of Western Australia.

However, they actually originated from debris emitted by the comet C / 1861 G1 Thatcher and have nothing to do with the star.

However, Toxorhynchites can consume all types of prey, organic debris ,, or even exhibit cannibalistic behavior.

However, because such weapons necessarily come into contact with large amounts of earth-based debris, they may, under certain circumstances, still generate significant fallout.

However, debris loosed by hydraulic mining above Marysville raised the riverbeds of both the Feather and the Yuba Rivers and rendered the city vulnerable to flooding during winter storms and spring run-offs.

However, not all parts of a spacecraft may be protected in this manner, e. g. solar panels and optical devices ( such as telescopes, or star trackers ), and these components are subject to constant wear by debris ( and to a much lesser extent, micrometeoroids ).

However, a re-analysis as better debris numbers became available reduced this to 1 in 221, and the mission was allowed to proceed.

However, not all of the muons are recycled: some bond with other debris emitted following the fusion of the nuclei ( such as alpha particles and helions ), removing the muons from the catalytic process.

However, a reference to a year 39 on a fragment found in the construction debris of Senusret's mortuary temple has suggested the possibility of a long coregency with his son.

However, firing at close range ran the risk of having to fly through the debris of a damaged or exploding aircraft, thereby damaging his own fighter in the process ( much of the damage Hartmann sustained in combat was caused by collision with flying debris ).

However, a walkway over the weir is likely to be useful for the removal of floating debris trapped by the weir, or for working staunches and sluices on it as the rate of flow changes.

However, flying glass debris must be entirely governed by drag and lift forces that overcome gravity for a considerable time period.

However he becomes trapped underneath fallen debris and when the spider is about to deliver the killing strike Ross flings the spider into the fire with a board that has fallen on his chest.

However, underground nuclear tests can " vent " to the surface, producing considerable amounts of radioactive debris as a consequence.

However, the organist and the children all had to wear hard hats as the risk of falling debris remained.

However speculation as to the identity of the Kecksburg object ( if there was one — reports vary ) also range from it being an alien craft to debris from Cosmos 96, a Soviet satellite.

However, debris and bacteria can easily accumulate under an operculum, which may cause pericoronitis, a common infection problem in young adults with partial impactions that is often exacerbated by occlusion with opposing third or second molars.

However, in his dream, Mollari is standing on a sandy landscape with pieces of metallic debris lying around ( it was speculated that he's standing on the ruins of a Centauri city that was attacked by the Shadows ).