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However the unexpected discovery of the strong respiratory stimulant effects of the ampakine drugs on the pre-Botzinger complex of the brain has led to continued development of an intravenous formulation of CX-717 for use alongside opioid analgesics, along with an oral formulation of CX-1739, which is around 3-5x more potent than CX-717 and has better oral bioavailability, and is being trialled for treatment of sleep apnoea.
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However and unexpected
However, the government had become destabilized by Alfonso XII's unexpected death in 1885, followed by the assassination of prime minister Antonio Cánovas del Castillo in 1897.
However, many of the plans framed by Nehru and his colleagues would come undone with the unexpected partition of India in 1947.
However, when confronted with totally unexpected phenomena, such as the first evidence for invisible radiation, experimental scientists often use the same approach as historical scientists: construct a set of hypotheses about the causes and then look for a " smoking gun ".
However, unexpected events force Fergus to decide what he wants for the future, and ultimately what his nature dictates he must do.
However, each of these states ( with the possible exception of Yugoslavia ) had large German and Hungarian minorities, there creating some unexpected problems that would be brought to light in the next two decades.
However, the unexpected death of Otto III in 1002 and the reorientation of the Holy Roman Empire politics by his successor Henry II, the wedding is delayed until 1012, when Bolesław I demanded the wedding and sent his son to Germany with gifts to his bride's family, who at that time quarreled with Henry II for Mathilde's dowry.
However, after the sudden and unexpected death of Raymond in 1772, he was recalled to Annonay to run the family business.
However, the unexpected surge of the new Conservative Party of Canada in parts of Quebec, particularly in and around Quebec City, led to the Bloc losing eight seats to the Tories.
However, the Egyptians were defeated by the unexpected attack of the Babylonians and were eventually expelled from Syria.
However, the Oilers unexpected run in the playoffs came to a crashing halt, as the Blackhawks dominated every game and swept the series 4 – 0.
However, he falls to a carefully planned counter-attack, culminating in a battle with Kal-L ( the Earth-Two Superman ), Alexander Luthor of Earth-Three, and Superboy of Earth-prime, with some unexpected last-second help from the New Gods ' adversary, Darkseid.
However when the economy is hit by some unexpected external shock, it may be a good idea to offset the macroeconomic effects of the shock with monetary policy.
However, since HPFS lacks a journal, any recovery after an unexpected shutdown or other error state takes progressively longer as the filesystem grows.
However, local miners tell of the " Stone Wall ," an unexpected and virtually insurmountable underground geological fault hit midway between Jerome and Boswell that prevented the linking of the two mines at a reasonable cost.
However, it was acquired by Miramax and released to unexpected success, going on to earn more than $ 13, 000, 000 worldwide.
However, a fateful connection would provide a sudden and unexpected change in fortune for the group.
However, the flanking troops were caught in the rear by an unexpected Russian counter-attack and Cathcart was shot from his horse and killed, leaving his troops disorganised and the attack broken up.
However an unexpected sortie from the pā caused great alarm and further infuriated Despard.
However, it also had unexpected negative consequences that would not reveal themselves fully until the 1986 Chernobyl disaster.
However, he was overwhelmed by Epitaph's new popularity ( including the unexpected success of the label's then-current acts The Offspring and Rancid ) and decided to quit Bad Religion once again in 1994.
However, if concurrent transactions with interleaving operations are allowed in an uncontrolled manner, some unexpected, undesirable result may occur.
However, “ it has been acknowledged that appraisals conducted more frequently ( more than once a year ) may have positive implications for both the organization and employee .” It is suggested that regular performance feedback provided to employees may quell any unexpected and / or surprising feedback to year-end discussions.
However, despite Christof's control, Truman has managed to behave in unexpected manners, in particular falling in love with an extra, Sylvia ( known to Truman as Lauren ), instead of Meryl, the character intended to be his wife.
However, the company may or may not incur unexpected costs to train these overseas workers.
However an unexpected sortie from the pā resulted in the temporary occupation of the knoll on which Tāmati Wāka Nene had his camp and the capture of Nene's colours-the Union Jack.
However and discovery
However, since the discovery of extensive deposits in locations such as Brazil, it has lost most of its value.
However the exact relationship of the term Ahhiyawa to the Achaeans beyond a similarity in pronunciation is hotly debated by scholars, even following the discovery that Mycenaean Linear B is an early form of Greek ; the earlier debate was summed up in 1984 by Hans G. Güterbock of the Oriental Institute.
However, there is no record of this incident in Bradley's own account of the discovery, and it may therefore be apocryphal.
However, the area has aroused considerable interest from oil companies in the light of the discovery of rich reserves of high grade crude oil elsewhere in Nigeria.
However, although these early writers contributed greatly to the philosophical discovery of mind and this would ultimately lead to the development of psychology, they were working with an entirely different set of tools and core concepts than those of the cognitive scientist.
However, the later discovery of the photoelectric effect demonstrated that under different circumstances, light can behave as if it is composed of discrete particles.
However, it remains ambiguous whether the discovery predates arrival of Europeans because of the presence of a Patagonian Missionary Society mission station on Keppel Island, founded in 1856.
However, most chemists followed Kekulé's lead in pursuing and developing what some have called " classical " structure theory, which was modified after the discovery of electrons ( 1897 ) and the development of quantum mechanics ( in the 1920s ).
However, the reason for this correction to the partition function remained obscure until the discovery of quantum mechanics.
However, the Delft merchants had decided to keep the discovery secret and returned in 1615 to hunt for their own profit.
However, the discovery of the object 1996 PW, an asteroid in an orbit more typical of a long-period comet, suggests that the cloud may also contain rocky objects.
However host discovery or ping scanning or ping sweep is still a part of network scanning tools like nmap, as it may give basic evidence about the existence of a remote machine.
However immediately after his discovery he did not improve it, allegedly because of an agreement to spend the next five years developing the New York City electric light and power system.
However, recent DNA analysis and the discovery of a common ancestor has supported the view that they share a common lineage, and thus rabbits and rodents are now often referred to together as members of the superclass Glires.
However, the presence of man in the Lower Paleolithic is attested by the discovery of stone tools characteristic of Acheulean such as hand axes reported by Théodore Monod at the tip of Fann in the peninsula of Cap-Vert in 1938, or cleavers found in the south-east .< ref > Abdoulaye Camara et Bertrand Duboscq, La préhistoire dans le Sud-Est du Sénégal, Actes du 2 < sup > e </ sup > Colloque de Kédougou, 18 – 22 fév.
However, the discovery of oats and barley on the plains at about 15, 000 BC suggests that agriculture had already developed at this early date.
However, the influence of evolution on behavior has been of interest to biologists and philosophers since soon after the discovery of evolution itself.
However, tin and lead can be smelted by placing the ores in a wood fire, leaving the possibility that the discovery may have occurred by accident.
However, research indicates that open-source software does have a higher flaw discovery, quicker flaw discovery, and quicker turn around on patches.
However, the subsequent discovery of the Kuiper belt, and in particular of the object, which is larger than Pluto yet does not fit Bode's law, have further discredited the formula.
However, Faraday was the first to publish the results of his experiments and thus receive credit for the discovery.
However, a number of observations including the discovery of cosmic acceleration in 1998 have revived the cosmological constant, and the current standard model of cosmology includes this term.
However he soon reversed this rosy assessment, when on October 23, 1854, The Times of London published a report by explorer-physician John Rae of the discovery by Eskimos of the remains of the lost Franklin expedition along with unmistakable evidence of cannibalism among members of the party:
However, modern historians have confirmed Rae's discovery of the Northwest Passage and the accuracy of his report on cannibalism among Franklin's crew.
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