Hydrocodone is often compounded with other generally less effective non-opioid compounds such as paracetamol ( also known as acetaminophen ) or ibuprofen, both often added to discourage recreational use ( as paracetamol can cause potentially fatal liver toxicity at high doses ), and to provide a possible synergy of analgesic effects between hydrocodone and the non-opioid compounds present.

Hydrocodone also can be combined with aspirin ( e. g., Lortab ASA ) and ibuprofen ( e. g., Vicoprofen ).

See also: Hydrocodone / paracetamol ( Vicodin ).

Hydrocodone is typically found in combination with other drugs such as paracetamol, aspirin, ibuprofen and homatropine methylbromide.

Hydrocodone is not commercially available in pure form in the United States due to a separate regulation, and is always sold with an NSAID, paracetamol, antihistamine, expectorant, or homatropine.

Hydrocodone can usually be successfully used with duloxetine ( Cymbalta ) for neuropathic pain, especially that from diabetic neuropathy, provided that the patient has normal relative and absolute levels of Cytochrome P450-related liver enzymes.

Hydrocodone is one of the most common recreational prescription drugs in America, along with oxycodone.

Hydrocodone is regulated in the same fashion as in Germany ( see below ) under the Austrian Suchtmittelgesetz ; since 2002 it has been available in the form of German products and those produced elsewhere in the European Union under Article 76 of the Schengen Treaty — prior to this, no Austrian companies produced hydrocodone products, with dihydrocodeine and nicomorphine being more commonly used for the same levels of pain and the former for coughing.

Hydrocodone is used to treat moderate to severe pain and as an antitussive to treat cough.

Common street names for Hydrocodone include: " hydros ", " dones ", " vics ", and " itchies ".

Hydrocodone may be quantitated in blood, plasma or urine to monitor for misuse, confirm a diagnosis of poisoning or assist in a medicolegal death investigation.

Hydrocodone is no longer available for medical use.

Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from either of two naturally occurring opiates: codeine and thebaine.

Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim.

Hydrocodone and compounds containing it are marketed, in varying forms, under a number of trademarks, including Anexsia, Biocodone, Damason-P, Dicodid, Duodin, Hycet, Hycodan ( or, generically, Hydromet ), Hycomine, Hydrococet, Hydrokon, Hydrovo, Kolikodol, Lorcet, Lortab, Mercodinone, Norco, Norgan, Novahistex, Orthoxycol, Panacet, Symtan, Synkonin, Vicodin, Xodol and Zydone.

Hydrocodone can be habit-forming, which leads to physical and psychological dependence.

Hydrocodone is biotransformed by the liver into several metabolites, and has a serum half-life that averages 3. 8 hours.

Hydrocodone in particular, and the-codone family of opioids in general, have been shown to have a liability to cause long term hearing loss over periods of use, though these actual findings are quite rare.

Hydrocodone presents much of the same side-effects as other opioids including euphoria, sedation and somnolence.

Hydrocodone is listed under the Betäubungsmittelgesetz as a Suchtgift in the same category as morphine.

Hydrocodone was until recently the active antitussive in more than 200 formulations of cough syrups and tablets sold in the United States.

* U. S. National Library of Medicine: Drug Information Portal – Hydrocodone

* Hydrocodone, a narcotic analgesic closely related to codeine is first synthesized in Germany.

There is also the traditional village politics of the Samoa Islands, the " faamatai " and the " faasamoa ", which continues in American Samoa and in independent Samoa, and which interacts across these current boundaries.

The amount of protection provided by any one antioxidant will also depend on its concentration, its reactivity towards the particular reactive oxygen species being considered, and the status of the antioxidants with which it interacts.

Conway's Game of Life and fractals are also considered mathematical puzzles, even though the solver only interacts with them by providing a set of initial conditions.

The resolution is also limited by the size of the interaction volume, or the extent to which the material interacts with the electron beam.

If the tachyon interacts with any other particles, it can also radiate Cherenkov energy into those particles.

A web container ( also known as a Servlet container ) is essentially the component of a web server that interacts with the Servlets.

Tigger also interacts enthusiastically with all the other characters — sometimes too enthusiastically for the likes of Rabbit, who is sometimes exasperated by Tigger's constant bouncing, Eeyore, who is once bounced into the river by Tigger, and Piglet, who always seems a little nervous about the new, large, bouncy animal in the Forest.

In optics, ultrashort laser pulses also exhibit chirp, which, in optical transmission systems interacts with the dispersion properties of the materials, increasing or decreasing total pulse dispersion as the signal propagates.

As the cognac interacts with the oak barrel and the air, it evaporates at the rate of about three percent each year, slowly losing both alcohol and water Because the alcohol dissipates faster than the water, cognac reaches the target 40 % alcohol by volume in about four or five decades, though lesser grades can be produced much sooner by diluting the cognac with water, which also makes its flavor less concentrated.

* Kim Newman has also written a series of short stories about Moriarty, narrated Watson-style by Colonel Moran, in which Moriarty interacts with many of his fictional contemporaries.

Light from the source enters one side, interacts with the sample ( usually also temperature controlled ) in the magnetic field, and exits through the opposite window to the detector.

He also developed such routines as an all-gorilla version of Swan Lake, a poker game set to Beethoven's Fifth Symphony, the Silent Show, in which Eugene interacts with the world accompanied solely by music and sound effects, parodies of typical television commercials and movie genres, and various musical segments with everyday items ( such as kitchen appliances or office equipment ) moving in sync to music.

ACTH interacts with receptors on adrenocortical cells and cortisol is released from the adrenal glands ; adrenal hypertrophy can also occur.

In the electroweak theory, the W also carries electric charge, and hence interacts with a photon.

Na < sup >+</ sup >- K < sup >+</ sup > pump also interacts with ankyrin, IP3R, PI3K, PLC-gamma and cofilin.

Web container ( also known as a Servlet container ) is the component of a web server that interacts with Java servlets.

Hall believed that the value in studying proxemics comes from its applicability in evaluating not only the way man interacts with others in his daily life, but also " the organization of space in his houses and buildings, and ultimately the layout of his towns.

As the load phase interacts with a database, the constraints defined in the database schema — as well as in triggers activated upon data load — apply ( for example, uniqueness, referential integrity, mandatory fields ), which also contribute to the overall data quality performance of the ETL process.

Such elements include the essential idea of narrative structure, with identifiable beginnings, middles and ends, or exposition-development-climax-denouement, with important inciting incidents, normally constructed into coherent plot lines ; a strong focus on temporality that includes retention of the past, attention to present action and protention / future anticipation ; a substantial focus on characters and characterization which is " arguably the most important single component of the novel " ( David Lodge The Art of Fiction 67 ); a given hetergloss of different voices dialogically at play, " the sound of the human voice, or many voices, speaking in a variety of accents, rhythms and registers " ( Lodge The Art of Fiction 97 ; see also the theory of Mikhail Bakhtin for expansion of this idea ); possesses a narrator or narrator-like voice, which by definition " addresses " and " interacts with " reading audiences ( see Reader Response theory ); communicates with a Wayne Booth-esque rhetorical thrust, a dialectic process of interpretation, which is at times beneath the surface, conditioning a plotted narrative, and other at other times much more visible, " arguing " for and against various positions ; relies substantially on now-standard aesthetic figuration, particularly including the use of metaphor, metonymy, synecdoche and irony ( see Hayden White, Metahistory for expansion of this idea ); is often enmeshed in intertextuality, with copious connections, references, allusions, similarities, parallels, etc.

Shh also induces other proteins with which it interacts and these interactions can influence the sensitivity of cell towards Shh.

Conway's Game of Life and fractals, as two examples, may also be considered mathematical puzzles even though the solver interacts with them only at the beginning by providing a set of initial conditions.

Mg < sup > 2 +</ sup > generally interacts with substrates through inner sphere coordination, stabilising anions or reactive intermediates, also including binding to ATP and activating the molecule to nucleophilic attack.

Furthermore, FANCG is identical to post-replication repair protein XRCC9, hinting at the possibility that FANCG also interacts directly with DNA by means of its internal leucine zipper.

Complications have also been observed in other human patients: high-dosage H. perforatum interacts with a wide range of medications due to activation of the Pregnane X receptor detoxification pathway, as well as causing photosensitivity.