The Cantigas de Santa Maria (" Canticles of Holy Mary ";, ) are 420 poems with musical notation, written in Galician-Portuguese during the reign of Alfonso X El Sabio ( 1221 – 1284 ) and often attributed to him.

* Studies on the " Cantigas de Santa Maria ": Art, Music, and Poetry: Proceedings of the International Symposium on the " Cantigas de Santa Maria " of Alfonso X, el Sabio ( 1221 – 1284 ) in Commemoration of Its 700th Anniversary Year – 1981.

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*( 3 ) Princess Margaret of Scotland, daughter of King William I of Scotland and Ermengarde de Beaumont ( 1221 ), by whom he had a daughter, Margaret ( c. 1222-1237 ), called " Megotta ", who married Richard de Clare, Earl of Gloucester, but had no issue.

His arrogance was tolerated while the regency was still in need of papal assistance ; but in 1221 Hubert de Burgh and the primate Stephen Langton successfully moved the pope to recall Pandulf and to send no other legate a latere ( of the highest rank ) in his place.

* Robert de Vere, 3rd Earl of Oxford ( c. 1173 – 1221 )

Roger Bigod ( – 1221 ) was the son of Hugh Bigod, 1st Earl of Norfolk and his first wife, Juliana de Vere.

Pierre Mauclerc ( c. 1190 – 6 July 1250 ), also known as Peter of Dreux or Pierre de Dreux, was duke of Brittany jure uxoris from 1213 to 1221, then regent of the duchy ( for his minor son ) from 1221 to 1237 as well as Earl of Richmond from 1219 to 1235.

Raymond-Roupen of Antioch or Raimond Rupen de Poitiers ( 1199 – 1219 or 1221 / 1222 ) was Prince of Antioch between 1205 and 1208 and between 1216 and 1219 / 1221 and " Rex Iunior " of Armenia between 1199 and 1221 / 1222.

Saint Dominic (), also known as Dominic of Osma and Dominic of Caleruega, often called Dominic de Guzmán and Domingo Félix de Guzmán ( 1170 – August 6, 1221 ), was the founder of the Dominican Order.

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In 1217 King John granted a mill worth 100 /- a year, situated in Dartford to Michael de Wallensi and in 1221 William, Prior of Rochester, granted to Alan Martel, Prior of the Knights Templars, half an acre of land by the mill.

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It was founded by the Normans in 1066, rebuilt by Ralph de Keynes in 1100, and the tower and north chapel were added by William de Keynes in 1221.

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The rhymed Latin inscription gives the painter's name as Guido de Senis, with the date 1221.

It was militarised by Peter of Roche, the Bishop of Winchester, during the Fifth Crusade 1217 – 1221.

However, papal letters mentioning an unidentified Bishop of Finland in 1209, 1221, 1229 and 1232 have survived.

Nevertheless, someone was eventually appointed and installed as the new bishop, since Pope Honorius III sent a letter directly to an unnamed Bishop of Finland in 1221.

In 1397 Richard II and the Bishop of Salisbury confirmed an order dated the 29th April 1221 allowing an annual fair to be held in the town.

Eustace of Fauconberg was a medieval English Bishop of London from 1221 to 1228 and was also Lord High Treasurer.

The Pope mentions this in 1221 in his letter to the unnamed Bishop of Finland who was now authorized to establish a trade embargo against the hostiles.

Shortly after deforestation, in 1221, a charter for a Friday market at Brewood was granted to the Bishop of Coventry and Lichfield by King Henry III, suggesting considerable growth and increased prosperity since the Domesday survey.

Pelagius hoped Frederick II would arrive with a fresh army, but he never did ; instead, after a year of inactivity in both Syria and Egypt, John of Brienne returned, and the crusaders marched south towards Cairo in July 1221.

In March 1221, the Mongols returned to Azerbaijan and besieged Maragheh, using prisoners as the vanguard to take the brunt of each assault on the city.

There was one known instance in history that a calipha ruled a Caliphate: Sitt al-Mulk was regent of the Fatimid Caliphate from 1221 to 1223.

In the mid-12th century, an independent state of Khorazm along the Oxus River broke away from the weakening Karakitai, but the bulk of the Kara-Khitan lasted until the Mongol invasion of Genghis Khan in 1219 – 1221.

A series of Arab revolts between 1221 and 1243 led King Frederick II to move much of the Arab population to a colony at Lucera, while Christians from Bonifato came to inhabit the city.

His reign spanned the years from 1210 through 1221.

This reign spanned the years from 1221 through 1232.

In 1221, because of the Jōkyū Incident, an unsuccessful attempt by Emperor Go-Toba to seize real power, the Kamakura shogunate completely excluded those of the imperial family descended from Emperor Go-Toba from the Chrysanthemum throne, thus forcing Emperor Chūkyō to abdicate.

He ruled from July 29, 1221 to October 26 (?

During this period, the city is again linked to the political choices, to Milan in 1221 that supports Monza, where the mayor had been excommunicated by the Archbishop of Milan, Enrico from Settala.

Alfonso X ( 23 November 1221 – 4 April 1284 ), called the Wise (), was the King of Castile, León and Galicia from 30 May 1252 until his death.

This arrangement excluded members of the Laskarid family from the succession, and when John III Doukas Vatatzes became emperor in mid-December 1221, he had to suppress opposition to his rule.

After the Mongol assault in Iran from 1219 to 1221 and slaughter of the learned men, some of them fled and went out to Greater Khurasan ( now northern Afghanistan ), of whom a large number also took refuge in sub-continent ( current India and Pakistan ).

According to Ibn Bibi, in 618 / 1221 the Saljuq of Rum Ala ' al-Din Kay-kubad decorated the walls of Konya and Sivas with verses from the Shahnameh.

At that time, many prominent gokenin, including the Mori clan ( 1221 ) and the Ōtomo clan, moved from the east to the west.

Abū Hamīd bin Abū Bakr Ibrāhīm ( 1145-1146-c. 1221 ; ), better known by his pen-names Farīd ud-Dīn ( فریدالدین ) and ‘ Attār ( عطار-" the perfumer "), was a Persian Muslim poet, theoretician of Sufism, and hagiographer from Nīshāpūr who had an abiding influence on Persian poetry and Sufism.

The Yukon government owns the highway from Historic Mile 630 to Historic Mile 1016 ( from near Watson Lake to Haines Junction ), and manages the remainder to the U. S. border at Historic Mile 1221.

Though there is much evidence of early historic settlement and transport, Stroud parish was originally part of Bisley, and only began to emerge as a distinct unit by the 13th century, taking its name from the marshy ground at the confluence of the Slad Brook and the River Frome called " La Strode " and was first recorded in 1221.