A 2006 Cochrane Collaboration review of controlled trials of antipsychotics in old age dementia reported that one or two of the drugs showed a modest benefit compared to placebo in managing aggression or psychosis, but that this was combined with a significant increase in serious adverse events.

In 2006, the primary economic concerns focused on: high national debt ($ 9 trillion ), high non-bank corporate debt ($ 9 trillion ), high mortgage debt ($ 9 trillion ), high financial institution debt ($ 12 trillion ), high unfunded Medicare liability ($ 30 trillion ), high unfunded Social Security liability ($ 12 trillion ), high external debt ( amount owed to foreign lenders ) and a serious deterioration in the United States net international investment position ( NIIP ) (- 24 % of GDP ), high trade deficits, and a rise in illegal immigration.

These issues have raised concerns among economists and unfunded liabilities were mentioned as a serious problem facing the United States in the President's 2006 State of the Union address.

In New South Wales, retrials of serious cases with a minimum sentence of 20 years or more are now possible, whether or not the original trial preceded the 2006 reform.

As it turned out, 2006 would prove to be the worst season for Essendon under Sheedy, and its worst in over 70 years, with a multitude of injuries and poor form affecting the team, none more so than the serious hamstring injury suffered by newly appointed captain Lloyd.

* 2006 – Prime Minister Ariel Sharon of Israel suffers a second, apparently more serious stroke.

Life of Brian has regularly been cited as a serious contender for the title " greatest comedy film of all time ", and has been named as such in polls conducted by Total Film magazine in 2000, the British TV network Channel 4 in 2006 and The Guardian newspaper in 2007.

Hmeida was arrested in January 2006 on charges of " serious crimes against the country's essential economic interests ".

The Alaska Supreme Court ruled in 2006 that a " conviction based on a no contest plea will collaterally estop the criminal defendant from denying any element in a subsequent civil action against him that was necessarily established by the conviction, as long as the prior conviction was for a serious criminal offense and the defendant in fact had the opportunity for a full and fair hearing ".

The Nationals were stung in early 2006, when their only Victorian senator, Julian McGauran, defected to the Liberals and created a serious rift between the Nationals and the Liberals.

" And in 2007 Schneider emphasized the danger of serious climate changes from a limited nuclear war of the kind analyzed in the 2006 study above, saying " The sun is much stronger in the tropics than it is in mid-latitudes.

The Left Party suffered serious losses in the 2006 elections for the city-state government of Berlin, losing nearly half of its vote and falling to 13 percent — slightly ahead of the Greens.

The old more serious newspaper Berlingske Tidende shifted from Broadsheet to Tabloid format in 2006, while keeping the news profile intact.

Additionally, the Oak Processionary Moth ( Thaumetopoea processionea ) has become a serious threat in the UK since 2006.

* " Bubble fusion: silencing the hype ", Nature online, March 8, 2006 — Nature reveals serious doubts over reports of fusion in collapsing bubbles ( subscription required )

Between 2006 and 2008, the crime rate fell by 16 %, while the first half of 2009 saw a reduction in serious crime of over 10 % from the previous year.

In 2006, the most serious humanitarian crisis in Africa was in Sudan's region Darfur.

More than 20 works-backed entries of Opel Astra, Audi TT and Mercedes-Benz CLK contested the revived 2000 DTM series but a serious issue developed for the series when Opel pulled out ahead of the 2006 season.

The General Medical Council appealed to the Court of Appeal and in October 2006 by a majority decision, with the Master of the Rolls, Sir Anthony Clarke, dissenting, the Court of Appeal upheld the decision of the High Court in part, ruling that Meadow's misconduct was not sufficiently serious to merit the punishment which he had received.

In January 2006, a U. S. Justice Department report was released which criticized the FBI for sloppy work but exonerated them of some more serious allegations.

By 2006 the campus had fallen into serious disrepair.

UK punk band Hacksaw came out against moshing after an incident at a 2006 gig caused several fans to suffer serious injuries.

In August 2006 following a torrential downpour of rain, the main street of Earlsdon suffered from serious flooding.

In June 2006 the group handed in a petition of over 3, 000 names to 10 Downing Street calling for a serious national debate about the future of the monarchy.

From 2002 to 2006 five deaths and 861 serious injuries were recorded.

On March 30, 2006, as a response to the controversy of the use of performance-enhancing drugs and the anticipated career home run record to be set by Barry Bonds, Selig asked former senator George Mitchell to lead an independent investigation into the use of steroids in baseball's recent past.

In November 2006, student government attempted to revive the " Dartmoose " as a potential replacement amid renewed controversy surrounding the former Indian mascot.

On January 20, 2006, Prime Minister Junichiro Koizumi devoted part of his annual keynote speech to the controversy, pledging to submit a bill allowing women to ascend the throne to ensure that the succession continues in the future in a stable manner.

The 2006 military conflict with Israel has increased the controversy.

In 2006, considerable controversy arose after the decision to cut 10 varsity teams ( including both men's and women's teams ) was deemed necessary by the Board of Visitors to comply with Title IX restrictions.

In February 2006, a long-lost copy of Hooke's handwritten notes from several decades of Royal Society meetings was discovered in a cupboard in Hampshire, and the balance-spring controversy appears, by evidence contained in those notes, to be settled in favour of Hooke's claim.

The possible movement of Hockey Night in Canada to another broadcaster caused some controversy and discussion during the 2006 – 2007 hockey season.

Wal-Mart created a controversy in 2006 when DVD shoppers were directed from Charlie and the Chocolate Factory and Planet of the Apes to the " similar item " Unforgivable Blackness: The Rise and Fall of Jack Johnson.

In 2007, controversy arose over CUP's decision to destroy all remaining copies of its 2006 book, Alms for Jihad: Charity and Terrorism in the Islamic World, by Burr and Collins, as part of the settlement of a lawsuit brought by Saudi billionaire Khalid bin Mahfouz.

In 2006, the Muslim nation of Pakistan crowned its first Miss Bikini Universe, Mariyah Moten, which later became a controversy worldwide.

Rapper Kanye West raised controversy when he appeared on the February 2006 cover of Rolling Stone wearing a crown of thorns.

Rather became embroiled in controversy about a disputed news report involving President Bush's Vietnam-era service in the National Guard and subsequently left CBS Evening News in 2005, and he left the network altogether after 43 years in 2006.

There was a small controversy in the community in February 2006, when it was announced that the Gay Games, which were scheduled to begin July 15, 2006 in Chicago, were seeking to hold the rowing events on Crystal Lake.

The name of the city came under some controversy in January 2006.

In July 2006, then-Mayor Lonegan created a controversy when he engineered a Borough Council resolution requesting the removal of a Spanish-language billboard in town advertising McDonald's iced coffee.

In September 2006, Wilsonville opened a new $ 9. 9 million, two-story brick and steel city hall after a controversy concerning its location led to unsuccessful attempts to recall several elected officials in the city, including the mayor.

In 2006, during the protests over cartoons depicting Muhammad, CAIR responded by launching an educational program " Explore the Life of Muhammad ", to bring " people of all faiths together to learn more about the Islamic Prophet Muhammad and to use mutual understanding as a counterweight to the tensions created by the cartoon controversy ".

On 23 March 2006, Gandhi announced her resignation from the Lok Sabha and also as chairperson of the National Advisory Council under the office-of-profit controversy and the speculation that the government was planning to bring an ordinance to exempt the post of chairperson of National Advisory Council from the purview of office of profit. She was re-elected from her constituency Rae Bareilly in May 2006 by a margin of over 400, 000 votes.

In September 2006, Tim Hortons courted controversy by mandating that employees were not to wear red as part of the Red Fridays campaign by families of the military to show support for Canadian troops.

During the Jyllands-Posten Muhammad cartoons controversy in 2006, several religious Iranian groups advocated changing the name of highly popular danish ( Shriniye Danmarki ), given its name association with the source country of the offending cartoons.

The new building opened in 2006 to controversy.

Science encountered another controversy in 2006 when papers by Hwang Woo-suk on cloning human embryos were withdrawn by Seoul National University due to apparent scientific fraud.

Both lackluster fundraising relative to Nelson and controversy over campaign contributions from MZM caused Harris to fall far behind in all polls by May 2006.